Dr.arnord Christopher

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26/08/2026
19/08/2026

🦴 50 SUPER HIGH-YIELD MUSCULOSKELETAL FOR USMLE πŸ’―πŸ”₯βœ…

πŸ”₯ Arthritis / Rheumatology

1. Gout β†’ needle-shaped, negatively birefringent MSU crystals; podagra.
2. Pseudogout β†’ rhomboid, positively birefringent CPPD crystals; knee/wrist.
3. Septic arthritis β†’ acute monoarthritis + fever; urgent joint aspiration.
4. Gonococcal arthritis β†’ migratory polyarthritis β†’ tenosynovitis β†’ pustular skin lesions.
5. Osteoarthritis β†’ pain worse with use, better with rest; DIP/PIP/1st CMC/knee/hip.
6. Rheumatoid arthritis β†’ symmetric MCP/PIP involvement + morning stiffness >1 hr.
7. RA antibodies β†’ anti-CCP = highly specific; RF less specific.
8. RA complications β†’ atlantoaxial subluxation, Felty syndrome, nodules, ILD.
9. Felty syndrome β†’ RA + splenomegaly + neutropenia.
10. SLE arthritis β†’ usually nonerosive, unlike RA.
11. Ankylosing spondylitis β†’ young male + inflammatory back pain + sacroiliitis.
12. AS association β†’ HLA-B27, uveitis, aortic regurgitation, apical lung fibrosis.
13. Reactive arthritis β†’ arthritis + urethritis/cervicitis + conjunctivitis; HLA-B27.
14. Psoriatic arthritis β†’ DIP disease, dactylitis, nail pitting, asymmetric arthritis.
15. IBD-associated arthritis β†’ peripheral arthritis and/or sacroiliitis.
16. Polymyalgia rheumatica β†’ age >50 + proximal shoulder/hip aching + ↑ESR.
17. Giant cell arteritis β†’ headache + jaw claudication + visual symptoms β†’ immediate steroids.
18. Dermatomyositis β†’ proximal weakness + heliotrope rash/Gottron papules.
19. Polymyositis β†’ proximal muscle weakness without characteristic skin rash.
20. Systemic sclerosis β†’ Raynaud + skin tightening + GI dysmotility; anti-Scl-70.

🦠 Bone & Joint Infections

21. Osteomyelitis β†’ bone pain + fever; S. aureus is the classic organism.
22. Sickle-cell osteomyelitis β†’ think Salmonella.
23. IV drug use osteomyelitis β†’ commonly S. aureus.
24. Vertebral osteomyelitis β†’ back pain + fever; consider S. aureus.
25. Septic arthritis β†’ purulent synovial fluid + very high WBC.

19/08/2026

πŸ”₯πŸ’― HY Immunology: 50 USMLE Buzzwords ‼️

1. 22q11 deletion + absent thymic shadow + hypocalcemia + conotruncal defects β†’ DiGeorge syndrome
2. Male infant + recurrent bacterial infections + absent tonsils β†’ X-linked agammaglobulinemia (Bruton)
3. BTK mutation β†’ failure of B-cell maturation β†’ X-linked agammaglobulinemia
4. Eczema + thrombocytopenia + recurrent infections + small platelets β†’ Wiskott-Aldrich syndrome
5. Ataxia + telangiectasias + ↑AFP β†’ Ataxia-telangiectasia
6. ATM mutation + defective DNA double-strand break repair β†’ Ataxia-telangiectasia
7. Recurrent catalase-positive infections + granuloma formation β†’ Chronic granulomatous disease
8. NADPH oxidase deficiency + abnormal DHR test β†’ Chronic granulomatous disease
9. Serratia + Staph aureus + Aspergillus + Nocardia + Burkholderia β†’ Chronic granulomatous disease
10. Delayed umbilical cord separation + no pus + neutrophilia β†’ Leukocyte adhesion deficiency
11. CD18 integrin deficiency β†’ Leukocyte adhesion deficiency type 1
12. Recurrent Neisseria meningitidis/gonorrhoeae β†’ C5–C9 deficiency
13. C5b-C9 deficiency β†’ defective membrane attack complex
14. Recurrent angioedema + no urticaria + low C4 β†’ Hereditary angioedema
15. C1 esterase inhibitor deficiency β†’ ↑ bradykinin β†’ hereditary angioedema
16. Recurrent sinopulmonary infections + low IgG + Giardia β†’ Common variable immunodeficiency
17. High IgM + low IgG/IgA/IgE β†’ Hyper-IgM syndrome
18. CD40L deficiency β†’ failure of class switching β†’ Hyper-IgM syndrome
19. Cold abscesses + eczema + coarse facies + retained primary teeth β†’ Job syndrome
20. STAT3 mutation + defective Th17 response β†’ Job syndrome
21. Severe infections + absent T cells and B-cell dysfunction β†’ SCID
22. ADA deficiency + ↑ deoxyadenosine/dATP β†’ SCID
23. X-linked SCID + common Ξ³-chain mutation β†’ defective IL-2/IL-4/IL-7/IL-9/IL-15 signaling
24. RAG1/RAG2 mutation β†’ failure of V(D)J recombination β†’ SCID
25. Absent MHC II expression β†’ Bare lymphocyte syndrome type II β†’ ↓ CD4 T cells

12/08/2026

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