Esoteric Vitality

07/06/2026

Taken 1 hr pre coffee or 1 hr post coffee......caffeine alters the metabolism of supplements in the liver.

Ive dropped my creatine gram amount to 3g daily taken with 6g of glutamine, ive done this as im also taking 3g of glycine at night. Both glutamine and glycine are precursors to the production of natural creatine in the body.

Assisting my gut integrity has not only reduced inflammation but also increased the nutrients my body is absorbing and utilizing from food.
This is a major factor when you ARE eating all the right foods and seeing very little results.

Your liver is also the major powerhouse in your body.......if its overwhelmed with excessive supplements or running at half tilt this is also a major factor in nutrient absorption along with immune function.

The performance of your liver alters the performance of EVERYTHING else.Your LIVER is also the organ that stores anger, rage and negative vibrations energetically!!!!

Dont just look if you are within the normal range of bloods of the liver, is it too low....., look at your kidney functioning also because this will back up waste removal when not running at full tilt.

So if you have poor gut permeability, poor liver functioning or poor kidney functioning this will cascade disease in your body.

There is NEVER just one area of treament, our body is like a spider web.....entwined and cofunctioning.

05/06/2026

Why is healthcare NOT a one stop shop......

Your body is not a vehicle that gets fed the same fuel the same oils the same coolant and just runs until it dies.

Your body is a hidden energy, a fortress and keeper of experiences, and a coded system running on pattern pathways.

As we HEAL our patterns change, they speak differents codes and hold changed energies......

Have you ever heard the saying "Dont live the same day after day and call it a life?"

Why subject your body to this same input.......As a student Clinician......you must grow with your body like a plant changes to the seasons......

Glycine is a non-essential amino acid that can be particularly helpful when taken in the evening because it supports several physiological processes involved in sleep, relaxation, and overnight recovery.

Benefits of Glycine at Night

1. May Improve Sleep Quality

Research suggests that 3 grams of glycine taken before bed can help people:
Fall asleep more easily
Experience deeper, more restorative sleep
Feel less fatigued the next day
Glycine acts as an inhibitory neurotransmitter in parts of the central nervous system, helping promote a calmer neurological state.

2. Helps Lower Core Body Temperature

One of glycine's unique sleep-promoting effects is its ability to slightly reduce core body temperature through increased blood flow to the skin. A drop in body temperature is a normal signal that helps initiate sleep.

3. Supports Stress Regulation

Glycine may help moderate nervous system activity and can support relaxation during periods of elevated stress or high cortisol. While it doesn't directly "lower cortisol" in all circumstances, many people report improved sleep when stress is contributing to insomnia.

4. Aids Overnight Recovery

Glycine is a major component of:
Collagen
Connective tissue
Cartilage
Skin

Taking glycine before bed may support the body's natural repair processes that occur during sleep.

5. Supports Blood Sugar Stability

Some studies suggest glycine may improve insulin sensitivity and help regulate glucose metabolism, which may be beneficial for people experiencing overnight blood sugar fluctuations.

6. May Support Growth Hormone Release

Quality sleep is closely linked to growth hormone secretion. By improving sleep quality, glycine may indirectly support recovery, muscle maintenance, and healthy body composition.

For Perimenopausal Women
For women in their 40s and 50s experiencing:

Night waking
Elevated evening cortisol
Anxiety
Difficulty recovering from exercise

03/06/2026

01/06/2026

Beautiful

23/05/2026

Why is alcohol in perimenopause like eating 50 chocolate cakes and gaining weight??????

The Estrobolome: Why Your Gut Bacteria Are Controlling Your Hormone Levels

Your gut bacteria processed your estrogen this morning. The question is whether they cleared it — or sent it back.

Most hormone conversations focus entirely on how much estrogen your body makes. Almost none of them ask the more clinically important question:

"how effectively is your body removing the estrogen it already made?"

The estrobolome is the collection of gut bacteria responsible for estrogen metabolism.

When it is functioning correctly, your liver conjugates estrogens, packages them for excretion in bile, they pass through your intestine, and exit the body in stool. Clean, efficient, complete.

When it is dysbiotic — when the wrong bacteria dominate — an enzyme called beta-glucuronidase unravels all of it.

It deconjugates the estrogens your liver already processed, frees them to be reabsorbed through your gut wall, and returns them to your bloodstream. Your liver did its job. Your gut bacteria undid the work. Quietly. Repeatedly.

This is called enterohepatic estrogen recirculation.

It is one of the most clinically significant and least discussed mechanisms of estrogen dominance in women — and in men.

The Molecular Sequence

🔹 Estradiol performs its function in tissues

🔹 The liver hydroxylates it through Phase I enzymes (CYP1A2, CYP3A4)

🔹 Phase II enzymes (UGT1A1, SULT1A1) conjugate it — glucuronic acid or sulfate group attached

🔹 Water-soluble, biologically inactive conjugated estrogens enter bile and reach the intestine

🔹 In a dysbiotic gut: beta-glucuronidase (from E. coli, Bacteroides, Clostridium) cleaves the glucuronic acid group

🔹 Free, biologically active estrogen is regenerated in the gut lumen

🔹 It is reabsorbed through the intestinal wall and returns to portal circulation

🔹 Serum estrogen rises — without any additional production from the ovaries

Between 30 and 60 percent of conjugated estrogens can be deconjugated and recirculated in a dysbiotic gut.

The liver is being asked to repeatedly process the same estrogens while its capacity is progressively depleted.

Why This Matters For Symptoms You Already Have

🔸Breast tenderness.
🔸Luteal phase mood instability.
🔸Heavier periods.
🔸Fluid retention.
🔸Unexplained weight gain around hips and abdomen.

The standard clinical reflex is to measure serum estradiol — which frequently comes back normal.

That normal result is not reassuring. It is incomplete.

A normal serum estradiol does not tell you:

🔸 Whether your 2:16 urinary metabolite ratio is unfavorable (16α-dominant = more estrogenically active pathway)

🔸 Whether your COMT enzyme is functioning — or impaired by B12 deficiency

🔸 Whether beta-glucuronidase is actively recirculating your already-conjugated estrogens

🔸 Whether your gut permeability is passively allowing sulfate-conjugated estrogens to reabsorb as well

You can have significant estrogen under-clearance pathology with a completely normal serum estradiol.
The test is measuring the wrong variable.

The B12-Folate-COMT Connection Most People Miss.

COMT (catechol-O-methyltransferase) is the enzyme that methylates and inactivates catechol estrogens — including the genotoxic 4-OH-E2 metabolites that form quinone intermediates capable of DNA damage.

COMT requires SAM-e as its methyl donor. SAM-e production requires folate and B12 as upstream cofactors.

⚠️ If you are on a proton pump inhibitor → B12 absorption is impaired through gastric acid suppression

⚠️ If you are on metformin → ileal B12 uptake is blocked through a separate calcium-dependent mechanism

⚠️ If you have an MTHFR polymorphism → folate-to-methylfolate conversion is functionally impaired

In any of these scenarios, COMT activity is running below capacity. Catechol estrogens accumulate. Genotoxic metabolites rise.

The methylation arm of estrogen inactivation partially shuts down — regardless of what your ovaries are producing.

Homocysteine above 9 μmol/L is the accessible clinical flag for this. It is inexpensive, widely available, and rarely ordered in hormone evaluations. It should be.

The Biomarkers That Actually Reveal This

🔬 Urinary 2:16 Estrogen Ratio → target >2.0 (2-OH dominant) — available on DUTCH test

🔬 Urinary 4-OH Estrogen Metabolites → should be low — genotoxic risk marker

🔬 Homocysteine → below 9 μmol/L — flags COMT methylation impairment

🔬 Methylmalonic Acid → functional B12 status at cellular level (more sensitive than serum B12)

🔬 SHBG → low levels compound recirculation risk — less buffering of free estrogens

🔬 F***l Beta-Glucuronidase Activity → direct measure of intestinal recirculation risk (GI-MAP, Genova)

🔬 Gut Microbiome Diversity (16S rRNA) → reduced Lactobacillus:Bacteroides ratio = higher beta-glucuronidase environment

Standard serum estrogen panels capture none of these variables.

The Restoration Protocol

Tier 1 — Food Signaling

🥗 30+ plant varieties per week — feeds Lactobacillus and Bifidobacterium, displaces beta-glucuronidase-expressing species

🥗 Cruciferous vegetables daily — DIM shifts Phase I toward 2-OH; sulforaphane activates Nrf2 Phase II enzymes; both mechanisms simultaneously

🥗 Eliminate high-fructose and ultra-processed foods — reduces gram-negative bacterial overgrowth driving beta-glucuronidase elevation

Tier 2 — Targeted Nutraceuticals

💊 Calcium-D-Glucarate 500-1000mg twice daily — direct competitive inhibitor of beta-glucuronidase in the intestinal lumen; prevents deconjugation of liver-processed estrogens

💊 DIM 200-400mg — CYP1A2 induction; shifts 2:16 ratio toward safer metabolic pathway; upregulates COMT

💊 Methylcobalamin B12 1000mcg sublingual + Methylfolate 400-800mcg — restores COMT methylation capacity; sublingual form bypasses PPI and metformin absorption impairment

💊 L-Glutamine 2-4g daily — enterocyte fuel; maintains tight junction integrity; reduces passive estrogen reabsorption

💊 Sulforaphane 30-50mg (broccoli sprout extract) — Nrf2 activation; induces GST and NQO1 Phase II enzymes; directly activates COMT gene expression

Tier 3 — Botanical Modulators

🌿 Berberine 500mg twice daily — selectively reduces E. coli and Bacteroides populations; reduces LPS translocation and NF-κB inflammatory impairment of Phase II enzymes

🌿 Milk Thistle/Silymarin 140-210mg three times daily — hepatoprotective; maintains UGT and SULT conjugation enzyme activity under chronic recirculation stress

Tier 4 — Pharmacological (physician-guided)

💉 Bioidentical progesterone — appropriate where documented luteal deficiency is confirmed; hormonal counterbalance, not clearance restoration; should not substitute for addressing the under-clearance root

💉 Pharmaceutical-grade I3C — medical-grade CYP1A2 inducer used in supervised hormone-dependent cancer prevention protocols

What You Learned From This Article

The estrobolome is the gut-level secondary regulation system for circulating estrogen that standard hormone testing was never designed to measure.

Estrogen dominance symptoms do not always mean overproduction.

They can be entirely driven by under-clearance — beta-glucuronidase recirculating already-conjugated estrogens, impaired COMT methylation from B12-folate insufficiency, and gut permeability allowing passive reabsorption of estrogens the body was attempting to excrete.

Calcium-D-Glucarate is a direct enzymatic inhibitor in a specific, named pathway — not a general supplement.

B12 and folate are not optional cofactors in this system — they are rate-limiting inputs for COMT, the methylation enzyme that inactivates the most genotoxic estrogen metabolites.

And the DUTCH test is the functional evaluation that reveals what serum hormone panels structurally cannot.

Way Forward / Next Steps For You

▶️ Increase plant diversity immediately — 30+ varieties weekly is the structural microbial shift that begins reducing beta-glucuronidase dominance. Add cruciferous vegetables to at least one meal daily.

▶️ Check homocysteine at your next blood draw. Above 9 μmol/L = COMT impairment. Begin sublingual methylcobalamin + methylfolate. If you are on a PPI or metformin, begin regardless.

▶️ Begin Calcium-D-Glucarate 500mg twice daily with meals if you have estrogen dominance symptoms — especially with a history of antibiotic use, PPI use, or a low-fiber diet that favors dysbiotic species.

▶️ Request a DUTCH test or equivalent urinary estrogen metabolite panel if hormonal symptoms persist despite normal serum estradiol.

This is the test that will reveal your 2:16 ratio, 4-OH metabolite burden, and methylation efficiency.

▶️ Add L-Glutamine 2-3g daily if you have any gut permeability history — IBS, chronic NSAID use, or known dysbiosis all compromise the intestinal barrier that is your last line of defense against estrogen reabsorption.

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Written by Edward Paul Mshani, BPharm
Registered Pharmacist By,
The Pharmacy Council Of Tanzania
Registration No: [0102390]
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Disclaimer — VitalDrop Rx

This content is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Do not stop or modify any prescribed medication or supplement regimen without consulting a qualified healthcare professional. Individual clinical decisions require personalized medical assessment.
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Sources:
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Tier 1 — Human Clinical Evidence
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Auborn KJ et al. — Indole-3-carbinol as a negative regulator of estrogen. J Nutr 2003.
Fuhrman BJ et al. — Associations of the f***l microbiome with urinary estrogens in postmenopausal women. J Clin Endocrinol Metab 2014.
Patel S et al. — Estrogen receptor and growth factor receptor pathway crosstalk. Cancer Res 1995.
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Tier 2 — Observational / Longitudinal
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Adlercreutz H et al. — Dietary components, enterohepatic circulation, and SHBG. J Steroid Biochem 1987.
Flores R et al. — F***l microbial determinants of f***l and serum estrogens. J Transl Med 2012.
Parkin KL et al. — Beta-glucuronidase in human intestinal bacteria. Biochemistry 1985.
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Tier 3 — Mechanistic / Preclinical
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Baker JM et al. — Estrogen-gut microbiome axis. Maturitas 2017.
Plottel CS & Bl**er MJ — Microbiome and malignancy. Cell Host Microbe 2011.
Ridlon JM et al. — Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006.
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