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10/26/2026

CoQ10 is essential for mitochondrial function - it plays a central role in the electron transport chain, the process by which your cells generate ATP, the energy currency of life.
Every cell in your body depends on it, with the highest concentrations in the heart.

Your body synthesizes CoQ10 through the mevalonate pathway - the same pathway that produces cholesterol. This is why statins, which block this pathway, are well-documented to deplete CoQ10. The recommendation to supplement CoQ10 alongside statins is widespread, and in that specific context it has merit.

But here is what the broader conversation misses:

When you supplement high-dose, isolated CoQ10 chronically, your cells register an abundance and downregulate their own synthesis through the mevalonate pathway.
When you stop supplementing - or when your absorption fluctuates - your mitochondria are left in a temporary deficit. The pathway needs time to restart. In that gap, people often experience profound fatigue, muscle weakness, and cardiovascular vulnerability.

You can end up creating the very deficiency you were trying to prevent.

The whole-plant difference:

Cardiotonic herbs like hawthorn berry, rosehips, and gynostemma are rich in anthocyanins, flavonoids, and trace minerals that do something different. Rather than supplying CoQ10 directly, they protect the mitochondria from the oxidative damage that depletes CoQ10 in the first place. They support the efficiency of the electron transport chain and provide the raw materials that allow the body to scale its own production appropriately.

They support the factory rather than replacing the product.

If you are on statins or have cardiovascular concerns, do not adjust your protocol without guidance from your prescribing physician.
Jeannine Sanderson, of Wholistic Life Support, is a clinical herbalist, not a medical doctor. This content is for educational purposes only and is not medical advice. If a supplement has been recommended by your physician, please consult them before making any changes to your protocol

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Wholistic Life Support

10/25/2026

Melatonin is probably the most casually consumed hormone supplement on the market. It’s in gummies, teas, chocolates, and children’s sleep products. Most people treat it like a glass of warm milk.

It is a hormone. And your body responds to it like one.

Your pineal gland produces melatonin in a precise, pulsed rhythm - tightly calibrated to light exposure, time of day, and the needs of your circadian system. When you take a synthetic melatonin supplement, especially at the 5–10mg doses commonly sold, you are flooding a system designed for micro doses.

Your pineal gland senses the surplus and goes quiet.
Over time, with regular use, it downregulates its own production. Your melatonin receptors (MT1 and MT2) begin to desensitize.
Your natural circadian rhythm flattens.

And then you can’t sleep without it.

What most people don’t know: melatonin is not just a sleep hormone. It is one of the most potent mitochondrial antioxidants in the body - protecting your cells during the repair and regeneration that happens overnight. When your natural production is suppressed, that protection diminishes.

The whole-plant difference:

Nervines and adaptogens -
herbs like ashwagandha, passionflower, and reishi -
do not force sedating hormones into your system.
Instead, they work upstream. They modulate the HPA axis, support the nervous system’s ability to downregulate cortisol (which is the primary suppressor of melatonin), and increase sensitivity to GABA - your brain’s natural calming neurotransmitter.

They create the biological conditions in which your own melatonin production can emerge naturally, as it was designed to, when the light goes down.

That is a fundamentally different relationship with your biology.

These herbs have contraindications, can interact with medications, and should be chosen based on your specific tissue state.
Please consult a qualified practitioner.

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Return to Your Self
Wholistic Life Support

Jeannine Sanderson, of Wholistic Life Support, is a clinical herbalist, not a medical doctor. This content is for educational purposes only and is not medical advice. If a supplement has been recommended by your physician, please consult them before making any changes to your protocol

10/23/2026

Glutathione is called the master antioxidant - and for good reason. It is one of the most powerful protective molecules your body produces, essential for detoxification, immune function, and cellular repair.

Your body makes it. Inside your cells. From three amino acids, through a tightly regulated process governed by an enzyme called γ-GCS.

Here is what most people selling you glutathione supplements don’t tell you:

When you flood your cells with high-dose exogenous glutathione - especially liposomal or IV - your cells sense a surplus. In response, they downregulate γ-GCS. They stop making their own.

But it goes deeper than that.

Your body doesn’t produce glutathione at a fixed rate. It produces it in response to stress - cellular stress, oxidative stress, inflammation. That stress signal travels through a pathway called Nrf2, which doesn’t just trigger glutathione production. It switches on dozens of other protective enzymes: superoxide dismutase, catalase, your phase II detoxification enzymes.

When you supplement the end product, Nrf2 stays silent. Those other enzymes never get activated. Your cellular defense system slowly loses its ability to respond on its own.

You haven’t healed anything.
You’ve bypassed your biology and created dependency.

The whole-plant difference:

Herbs like milk thistle, turmeric, and broccoli sprouts (rich in sulforaphane) do not contain glutathione. They are mild pro-oxidants - they create just enough cellular stress to activate Nrf2 and prompt your cells to build their own glutathione, along with the full cascade of protective enzymes that come with it.

The plant doesn’t give your body the answer.
It makes your body smarter.

Work with a qualified practitioner before adding or removing any supplement protocol.

Return to Wholeness
Return to Your Self
Wholistic Life Support

Jeannine Sanderson, of Wholistic Life Support, is a clinical herbalist, not a medical doctor. This content is for educational purposes only and is not medical advice. If a supplement has been recommended by your physician, please consult them before making any changes to your protocol.

10/22/2026

The wellness industry has a secret it doesn’t want you to know.

It borrowed its playbook from the pharmaceutical model -
isolated compounds, high doses, one molecule targeting one symptom - and put a green label on it.

And just like pharmaceuticals, it can teach your body to stop doing the very thing you’re trying to support.

Over the next several reels, we are going to look at some of the most popular supplements on the market -
glutathione, melatonin, CoQ10, zinc -
and examine what happens at the cellular level when you flood your body with an end product it was designed to make itself.

This is not an attack on all supplementation. Some supplements, used wisely and at the right time, serve a genuine purpose. This is about understanding why you’re taking something, what it does to your biology long term, and whether there is a smarter way.

Because root cause healing and symptom suppression are not the same thing - even when the bottle says natural.

As a clinical herbalist, I see this pattern consistently, I have even been guilty of it myself.
People leave conventional medicine, frustrated that nothing is working, and walk straight into the same model with a different aesthetic.

You deserve better than that.

Let’s start at the beginning.

Return to Wholeness
Return to Your Self
Wholistic Life Support

Jeannine Sanderson, of Wholistic Life Support, is a clinical herbalist, not a medical doctor. This content is for educational purposes only and is not medical advice. If a supplement has been recommended by your physician, please consult them before making any changes to your protocol.

09/12/2026

Tissue state carousel series-
Which state- or tissue states, most fit you?

In choosing the perfect herbs for an individual,
this is one of the MOST essential details to get right.
This is often the difference between getting better,
staying the same, or getting worse.

Before you use herbs medicinally- know your state!
Most of us have more than one.
I tend towards cold, dry, tense...

Which tissues states speak most loudly to you?
We move on to our last state here- damp relaxation.
You have now walked through all 6 tissues states, where do you see yourself most?

Return to Wholeness
Return to Your Self
Wholistic Life Support.

09/12/2026

Tissue state carousel series-

Which state- or tissue states, most fit you?

In choosing the perfect herbs for an individual,
this is one of the MOST essential details to get right.

This is often the difference between getting better,
staying the same, or getting worse.
Before you use herbs medicinally- know your state!
Most of us have more than one.

I tend towards cold, dry, tense...

Which tissues states speak most loudly to you?
We move on now to wind tension-
I know this one well... 😏

Return to Wholeness
Return to your Self
Wholistic Life Support

09/11/2026

Tissue state carousel series-

Which state- or tissue states, most fit you?

In choosing the perfect herbs for an individual,
this is one of the MOST essential details to get right.

This is often the difference between getting better,
staying the same, or getting worse.

Before you use herbs medicinally- know your state!

Most of us have more than one.
I tend towards cold, dry, tense...
Which tissues states speak most loudly to you?

We move on to dry atrophy,
and while this often goes hand in hand with heat,
dry can also go alone with cold.
And damp stagnation can also come alongside heat.

While some tissue states often commonly occur together,
it is not a hard rule.

09/11/2026

Tissue state carousel series-

Which state- or tissue states, most fit you?

In choosing the perfect herbs for an individual,
this is one of the MOST essential details to get right.

This is often the difference between getting better,
staying the same, or getting worse.

Before you use herbs medicinally- know your state!

Most of us have more than one.
I tend towards cold, dry, tense...
Which tissues states speak most loudly to you?

We move on to heat excitation- prone to anxiety

09/05/2026

Tissue state carousel series-

Which state- or tissue states, most fit you?

In choosing the perfect herbs for an individual,
this is one of the MOST essential details to get right.

This is often the difference between getting better,
staying the same, or getting worse.

Before you use herbs medicinally- know your state!

Most of us have more than one.
I tend towards cold, dry, tense...

Which tissues states speak most loudly to you?
We move on to damp stagnation, which can often go along with cold depression..

09/03/2026

Tissue state carousel series-
which state most fits you?

In choosing the perfect herbs for an individual,
this is one of the MOST essential details to get right.

This is often the difference between getting better,
staying the same, or getting worse.

Before you use herbs medicinally- know your state!

Most of us have more than one.
I tend towards cold, dry, tense...
Which tissues states speak most loudly to you?

We will start with Cold Depression.

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