Genes & Diseases Journal

Genes & Diseases Journal Genes & Diseases publishes research on the molecular basis and therapeutics of human diseases. (IF: 9.4; Scopus CiteScore: 8.4)

Formats include full-length articles, reviews, short communications, and more.

Are B cells quietly limiting the success of ?This review argues that immune evasion extends beyond , showing how defec...
11/09/2026

Are B cells quietly limiting the success of ?

This review argues that immune evasion extends beyond , showing how defects in antigen presentation, antibody isotypes, and B-cell organization suppress anti-tumor immunity while highlighting precision strategies to reprogram the for stronger therapeutic responses.

in : https://doi.org/10.1016/j.gendis.2026.102447

Broken bones are only part of the problem. lacks effective anabolic therapies because the mechanisms behind impaired bo...
10/09/2026

Broken bones are only part of the problem.

lacks effective anabolic therapies because the mechanisms behind impaired bone formation remain elusive, but this study identifies a betaine-driven pathway that suppresses , restores osteogenesis through the ABCG1–HMOX1 axis, and highlights a promising therapeutic strategy for . Chongqing University

in : https://doi.org/10.1016/j.gendis.2026.102444

Better autism treatments require understanding the biology behind synaptic dysfunction.This study from Chongqing Univers...
10/09/2026

Better autism treatments require understanding the biology behind synaptic dysfunction.

This study from Chongqing University identifies dysregulated ADAM10-mediated cleavage as a driver of prefrontal synaptic abnormalities, links plasma N-cadherin to social development in children with (ASD), and highlights the ADAM10/N-cadherin axis as a promising mechanism-based therapeutic target.

in : https://doi.org/10.1016/j.gendis.2026.102442

Too young. Too aggressive. is rising, yet its biology remains poorly understood, and this study reveals how the PPARγ–E...
09/09/2026

Too young. Too aggressive.

is rising, yet its biology remains poorly understood, and this study reveals how the PPARγ–EMP1 axis rewires to suppress CD8⁺ T cells, driving an immune-evasive while identifying a therapeutic target that enhances anti-PD-1 responses and supports age-specific treatment strategies. Zhejiang University

in : https://doi.org/10.1016/j.gendis.2026.102441

What if so-called encode proteins that shape disease?This review explores -derived ncRNA-encoded peptides as emerging...
09/09/2026

What if so-called encode proteins that shape disease?

This review explores -derived ncRNA-encoded peptides as emerging regulators across multiple organ systems, highlighting their potential as diagnostic , therapeutic targets, and innovative treatments for a broad spectrum of human diseases.

in : https://doi.org/10.1016/j.gendis.2026.102128

09/09/2026

Precision medicine is reshaping treatment.

This review highlights how targeted therapies and are improving outcomes, while addressing key challenges including drug resistance, the immunosuppressive , and the need for reliable biomarkers to guide personalized care. Zhejiang University

in : https://doi.org/10.1016/j.gendis.2026.102124

Restoring blood flow after a heart attack can paradoxically trigger further cardiac injury.This review explains how dr...
09/09/2026

Restoring blood flow after a heart attack can paradoxically trigger further cardiac injury.

This review explains how drive damage through inflammatory cell death and highlights emerging therapies targeting these pathways to reduce tissue injury and improve recovery after reperfusion. The Chinese University of Hong Kong, Shenzhen

in : https://doi.org/10.1016/j.gendis.2026.102117

Why do some breast cancers become more metastatic despite slower primary tumor growth?This study identifies mdig as a ke...
08/09/2026

Why do some breast cancers become more metastatic despite slower primary tumor growth?

This study identifies mdig as a key suppressor of , showing that its loss rewires epigenetic regulation to activate pro-metastatic genes, revealing a promising target to limit cancer spread. Stony Brook University

in : https://doi.org/10.1016/j.gendis.2026.102120

Can disease-causing proteins be eliminated instead of simply blocked?This review explores how technology harnesses tar...
08/09/2026

Can disease-causing proteins be eliminated instead of simply blocked?

This review explores how technology harnesses targeted protein degradation to tackle previously undruggable drivers of , offering a promising strategy to overcome drug resistance and advance precision therapies in . Southeast University, China

in : https://doi.org/10.1016/j.gendis.2026.102440

Not all airway ciliated cells function the same.This study creates a comprehensive atlas of cells across the healthy h...
08/09/2026

Not all airway ciliated cells function the same.

This study creates a comprehensive atlas of cells across the healthy human airway, revealing region-specific antioxidant defenses and distinct disease-associated molecular signatures that uncover new therapeutic targets for , COPD, and other chronic . National University of Singapore

in : https://doi.org/10.1016/j.gendis.2026.102438

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