The Secret Life Of Fascia

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The Secret Life Of Fascia

The Secret Life of Fascia gives an overview of the emerging research, field, and sub-culture of fascia science.
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09/08/2026

The myofascial rheostat: hyaluronan molecular weight dynamics and purinergic signalling as a physiological feedback system

“Contrary to popular belief, too much HA is evidently not better. In the myofascial system, HA behaves like a Goldilocks molecule: too little impairs gliding, but too much—or too viscous/densified—quickly becomes problematic…

“The notion of a structured form is the result of an architectural organization and a continuous, permanent link between all the components. The influence of various physical forces is crucial for maintaining a structured form.”

- Karen B. Kirkness, Et al.

Image: Reproduced from Architecture of Human Living Fascia by Jean-Claude Guimberteau (Figure 2.25), © Jessica Kingsley Publishers Limited. Reproduced with permission of the Licensor through PLSclear (Ref. 112545).

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08/08/2026

Vagus Nerve: World’s First Comprehensive Human Vagus Nerve Maps

“To better understand the function of each vagal fiber, this new resource offers a unique 3D view into the intricate microscopic anatomy of the human vagus nerve... By mapping the organization of fascicles and fibers, researchers can gain critical insights into how the vagus nerve communicates with various organs and influences human health and disease.”

The human vagus nerve contains about 100,000 individual nerve fibers, some as small as 0.5 micrometers.”

- Julianne Mosher Allen

Center for Bioelectronic Medicine

Feinstein Institutes for Medical Research

Photo credit: Northwell Health

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06/08/2026

Gut-Brain: “Disorders of gut-brain interaction (DGBI) may increase the risk for eating disorders (EDs), and the relationship appears to go both ways, according to a retrospective UK cohort study of more than 1.25 million people published in Clinical and Translational Gastroenterology. The investigators also found that depression is an independent risk factor for developing an ED among people with DGBI.”

“It is unclear whether DGBI directly predisposes individuals to one or more EDs or is a consequence of these disorders, nor is it clear whether anxiety and depression cause both EDs and DGBI, or whether, in these conditions, anxiety and depression are present simultaneously but have no causal link — that is, they represent only a comorbidity,”

- Stella-Maris C. Egboh, University of Newcastle, Callaghan, Australia.

Image: Medscape

Medscape

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30/07/2026

Neck Anatomy

Image: ogdukeneurosurg

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28/07/2026

Rest In Peace: “With deep sadness, we mourn the passing of Dr. Gunther von Hagens (1945–2026), the inventor of plastination and creator of BODY WORLDS.

With the invention of plastination in 1977, he transformed the field of anatomy and gave millions of people a unique insight into the human body. Together with Dr. Angelina Whalley, he created the BODY WORLDS exhibitions, which have inspired more than 58 million visitors around the world.

His life's work stands for science, education, and the belief that understanding our own bodies can lead to healthier, more conscious lives.

His legacy lives on—in scientific research, in the BODY WORLDS exhibitions, and in the memories of millions of people whose lives he touched.

Our thoughts are with his family and all those who knew and loved him.

🖤 1945–2026”

- gunthervonhagensbodyworlds

PLASTINARIUM

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24/07/2026

Mechanism of cellular senescence in musculoskeletal diseases. Analysis by Science News Highlights

“Cellular senescence drives the progressive degradation of joint and bone tissues in musculoskeletal diseases by fueling chronic localized inflammation and impairing tissue regeneration.

Research shows that as cells age or experience stress, they enter a state of permanent growth arrest while remaining highly metabolically active. This transition accelerates the onset of widespread conditions such as osteoarthritis (OA), osteoporosis, and intervertebral disc degeneration (IDD).

Telomere shortening from repetitive replication, elevated reactive oxygen species (ROS), and mechanical overload force joint cells (chondrocytes, synoviocytes, and osteoblasts) into senescence. These cells secrete the Senescence-Associated Secretory Phenotype (SASP)... SASP enzymes directly break down essential extracellular matrix components like type II collagen and aggrecan, systematically destroying cartilage and bone architecture

Senescent articular chondrocytes and synovial fibroblasts accumulate in the joint. The resulting SASP degrades joint cartilage, triggers chronic synovitis, and causes subchondral bone remodeling, leading to severe pain and joint immobility.

Senescence alters the bone remodeling balance. Senescent osteocytes and osteoblasts overproduce RANKL, which hyper-activates bone-resorbing osteoclasts while halting new bone formation, causing a steep drop in bone mineral density.

Senescent nucleus pulposus and annulus fibrosus cells drive matrix depletion and mechanical failure of the spinal discs, resulting in chronic discogenic back pain.

Clinical therapeutics involves targeting these zombie cells to halt or reverse musculoskeletal decline. Senolytics are small molecules designed to selectively induce apoptosis in senescent cells by temporarily disabling their built-in pro-survival pathways. Instead of killing the cell, senomorphics alter its behavior to suppress the toxic inflammatory output.”

Image: Authors

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22/07/2026

Fibromyalgia: “Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended.”

- New England Journal of Medicine

Infographic: New England Journal of Medicine

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18/07/2026

Sinonasal and Cranial Anatomy: Analysis by Nader Shawky

“Understanding the intricate cross-sectional anatomy of the head and neck is vital for diagnostic accuracy in radiology. Visualizing the relationships between these complex structures is a fundamental skill for medical professionals and international students alike.

Key Anatomical Landmarks

Sinonasal Structures:
The image highlights the nasal septum, nasal co**ha, and the maxillary sinus.

Pharyngeal and Auditory Anatomy: Essential landmarks include the nasopharynx, the mandible, and the air in the eustachian tube.

Cranial Landmarks:
Important structures such as the zygomatic arch and the mastoid are identified to provide critical clinical context.”

- Nader Shawky

Image:

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12/07/2026

Interoception: “Scientists have a word for how we sense ourselves from the inside: interoception.”

“Steve Liberles is decoding the vagus with molecular precision and finding that its messaging system is unexpectedly diverse. So far, his research has uncovered dozens of types of vagus nerve cells, each wired to a specific organ. Team Red relays information about the heart; Team Blue, the gut.

Within those teams, each courier has a unique job that’s different from those all its teammates perform. Liberles found 10 types in the lungs alone. Until then, only one lung reflex had ever been identified, in 1868. One nerve courier carries information about breathing rate; another the stretch of your lungs; yet another information about airway threats, like food going down the wrong pipe.”

- By Katherine W. Isaacs

Image Credit: STEPHANIE ARNETT/MIT TECHNOLOGY REVIEW | RAWPIXEL

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10/07/2026

Glymphatic System: “The glymphatic system is a new frontier in human physiology, and neuroscientists are only just beginning to sift through its muck and mire.

Today, most of our knowledge of this system is based on research in mice, but it appears that the brain's recycling efforts are most active during sleep.
This seems to be when toxic products or dead cells are flushed out of the mammalian brain, riding on 'waves' of cerebrospinal fluid. These pulses of liquid appear to be pumped by some obscure plumbing network that is still coming to light.”

Excerpt From
“In a First, Chronic Fatigue Syndrome Linked to The Brain's Clearing System”

Image: (Daisy-Daisy/iStock/Getty Images)

ScienceAlert

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