Dr Sayed Shabir Ahmad Saidy ډاکتر سیدشبیراحمد سیدی

20/07/2026

13/05/2026

Known case of Fanconi anemia

08/05/2026

🩸 د تلاسیمیا د نړیوالې ورځې پیغام 🩸

نن د مې ۸مه، د Thalassemia نړیواله ورځ ده.
تلاسیمیا د وینې یوه ارثي ناروغي ده چې پکې د انسان په بدن کې د وینې سری حجرې او هیموګلوبین په سمه توګه نه جوړیږي، له همدې امله ناروغ د کمزورۍ، ستړیا او د وینې کمښت سره مخ کېږي.
امازمونزدګران هیواد افغانستان په شمول په ډیرو وروسته پاتی هیوادنو کې اوس هم Thalassemia یوه جدي ارثي ناروغي بلل کېږي. هر کال زرګونه ماشومان د دې ناروغۍ سره زیږېږي، اوهرکال په زرهاو ماشومان ددی ناروغي له امله خپل ژوند له لاسه ورکوي .په ځانګړي ډول په هغه سیمو کې چې د واده مخکې طبي معاینات کم ترسره کېږي.
اوس په پرمختللو هېوادونو کې د Thalassemia پېښې او د دې ناروغۍ له امله د ماشومانو زیږون ډېر کم شوی دی. د دې اصلي لاملونه د واده مخکې سکریننګ، جنیټیک مشورې، او د امیندوارۍ پر مهال معاینات دي.

مهم ټکي:
• تلاسیمیا له مور او پلار څخه ماشوم ته انتقالېږي.
• دا ناروغي ساري نه ده.
• د وخت پر تشخیص او درملنې سره ناروغان عادي ژوند کولی شي.

د مخنیوي لپاره:
د واده نه مخکې د وینې معاینه وکړئ.
د تلاسیمیا ټېسټ او مشوره ضروري ده.
خلکو ته د دې ناروغۍ په اړه پوهاوی ورکړئ.

راځئ چې د پوهاوي، معاینې او احتیاط له لارې راتلونکی نسل د تلاسیمیا څخه خوندي وساتو.
Dr Sayed Shabir Ahmad (Saidy)
Consultant pediatrician
Pediatric Heam oncologist

26/04/2026

Known case of Xeroderma Pigmentosum
A 5-year-old male presented to us with following findings :
extreme photosensitivity, hyper- and hypopigmented macules on sun-exposed areas, dry atrophic skin, photophobia,keratitis and conjunctivitis. He also has short stature (height 92 cm), microcephaly (OFC 42 cm), and severe failure to thrive (weight 8 kg). He is born to consanguineous parents, and one sibling died of the same disease associated with bone cancer .

Management is multidisciplinary, involving a pediatrician, pediatric dermatologist, and pediatric ophthalmologist.
Prognosis is poor due to early predisposition to Basal Cell Carcinoma and Squamous Cell Carcinoma.

22/04/2026

Presenting Complaints & History

Muhammad Rehan is a Male,9 years old patient presented to us with following complaints

Weight Gain, Pigmentation increase on back of neck, bed wetting and aggressive behavior
Examination
BP: 100/60 mm HG, Weight: 54.1 kg (> 97 centile, +
2.77 SDS), Height: 134 cm (34 centile), BMI: 30.12 (>
97 centile)
Pallor +ve, Thyroid Swelling -ve, Clubbing -ve, Acanthosis Nigricans +ve, Abdominal Stria - ve
Systemic Examination:
GIT: NAD, Respiratory System: NVB + No added sound, CVS: S1 + S2 + 0, CNS: Intact SMR: SPL 4,0 cm, TV 1 ml, P1
Developmental History
Student of class 2 and weak In studles

labs: CBC: Normal,
TFT:FT4: 8.9 pg/ml, TSH: 3.6 ulu/ml,
Fasting Insulin: 76.2 pmol/L (10,97 ml/L),
Fasting Glucose: 74 mg/di, HOMA IR: 2.0, HbA1C: 5.9 %, Total Cholesterol: 95 mg/di
Dx And treatment plan?

21/04/2026

History Clues: patient presented with Blistering skin lesions since infancy,Hoarseness,Feeding difficulty due to oral ulcers,Recurrent stridor / breathing difficulty,Progressive nail changes,Family history + consanguinity .

Examination Findings:Fragile skin with erosions & exuberant granulation tissue,Crusted lesions around mouth & face,Hoarseness , Oral ulcers & mucosal granulation,Nail dystrophy or absent nails,± Eye involvement (conjunctival scarring and granulation )

Diagnosis:Laryngo-Onycho-Cutaneous (LOC) Syndrome(Shabbir Syndrome )

Treatment:Multidisciplinary care ( pediatric dermatologist , pediatric ENT specialist , pediatrician )

02/02/2026

* Duchenne muscular dystrophy
* Positive Gowers’ sign
* Calf pseudohypertrophy

21/11/2025

A 3-day-old infant is brought with a rash. O/E, chorioretinitis, hepatosplenomegaly & hemorrhagic purpuric eruptions are noted, with no cardiovascular abnormality. CBC and CT head shows the following Findings . What is the most likely diagnosis?

20/11/2025

𝗛𝗲𝗺𝗼𝗹𝘆𝘁𝗶𝗰 𝗨𝗿𝗲𝗺𝗶𝗰 𝗦𝘆𝗻𝗱𝗿𝗼𝗺𝗲 (𝗛𝗨𝗦) - 𝗛𝗶𝗴𝗵-𝗬𝗶𝗲𝗹𝗱 𝗦𝘂𝗺𝗺𝗮𝗿𝘆

𝗧𝗿𝗶𝗮𝗱: 𝗠𝗶𝗰𝗿𝗼𝗮𝗻𝗴𝗶𝗼𝗽𝗮𝘁𝗵𝗶𝗰 𝗵𝗲𝗺𝗼𝗹𝘆𝘁𝗶𝗰 𝗮𝗻𝗲𝗺𝗶𝗮 + 𝗧𝗵𝗿𝗼𝗺𝗯𝗼𝗰𝘆𝘁𝗼𝗽𝗲𝗻𝗶𝗮 + 𝗔𝗰𝘂𝘁𝗲 𝗿𝗲𝗻𝗮𝗹 𝗳𝗮𝗶𝗹𝘂𝗿𝗲

Often follows 𝗘. 𝗰𝗼𝗹𝗶 𝗢𝟭𝟱𝟳:𝗛𝟳 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻 → Shiga-like toxin damages endothelium → microthrombi → RBC destruction + ↓ platelets

𝗞𝗲𝘆 𝗙𝗲𝗮𝘁𝘂𝗿𝗲𝘀:

Anemia → fatigue, pallor, ↑ LDH

Thrombocytopenia → petechiae, bleeding

Uremia → renal failure, oliguria, ↑ creatinine

Often preceded by bloody diarrhea in children

𝗟𝗮𝗯𝘀:

Schistocytes

↓ Platelets

↑ LDH, ↑ BUN/Cr

Normal PT & aPTT

𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁:

Supportive care = mainstay

IV fluids, dialysis if needed

Avoid antibiotics (may ↑ toxin release)
Eculizumab → atypical or severe cases

𝗞𝗲𝘆 𝗙𝗮𝗰𝘁:

HUS = renal-dominant form of microangiopathic anemia

TTP = HUS + neurologic symptoms

Dr Sayed Shabir Ahmad (Saidy)
Consultant pediatrician
Pediatric Heam/oncologist