29/11/2025
INTERACTIONS THAT SHOULD BE AVOIDED
1:Do not combine tetracyclines with penicillins, as tetracyclines are bacteriostatic, while penicillins are bactericidal, which may lead to antagonistic effects.
2: Do not administer metronidazole (Flagyl) together with mebendazole, as this combination has been associated with Stevens-Johnson Syndrome (SJS). Albendazole is recommended as the safer alternative.
3: Avoid combining ondansetron with tramadol, because ondansetron significantly reduces the analgesic efficacy of tramadol by interfering with its serotonergic mechanism.
4: Avoid combining metronidazole (Flagyl) with warfarin, as metronidazole greatly increases INR and may lead to severe or life-threatening bleeding.
5: Do not combine calcium channel blockers (such as verapamil or diltiazem) with beta-blockers, because this combination can cause profound bradycardia, AV block, or even cardiac arrest.
6:Never administer sildenafil (Vi**ra) with nitrate-containing medications, as this combination causes marked vasodilation, leading to a potentially fatal drop in blood pressure.
7: Avoid combining furosemide (Lasix) with aminoglycosides such as gentamicin or amikacin, due to the significantly increased risk of ototoxicity (hearing loss).
9:Do not administer high-dose Omega-3 supplements (more than 3 g/day) with antiplatelet agents such as aspirin, since this may increase the risk of bleeding.
