Holy Pacha

05/09/2026

THC and CBD don’t just appear — they’re transformed. 🌱
From CBGA to THCA & CBDA, and finally THC & CBD through heat, light, and time. Science matters.

HOW ARE THC & CBD PRODUCED?

THC and CBD are not produced directly by the cannabis plant, they are the result of external processes such as oxidation or decarboxylation of cannabinoids in their acid form (THCa and CBDa) by exposure to light, heat or oxygen.

04/04/2026

H**p Education in 2026.

04/01/2026

Cannabis can help with several types of pain.

For chronic conditions like arthritis, back pain, and fibromyalgia, a combination of THC and CBD often works best.

It is also highly effective for nerve pain, such as sciatica and diabetic neuropathy, by calming overactive nerve signals.

For inflammatory pain, including muscle soreness and autoimmune conditions, CBD-dominant products can reduce inflammation without causing a high.

Cannabis is also used for cancer-related pain, helping ease discomfort while reducing nausea and improving appetite alongside traditional treatments.

04/01/2026

🧠🌿 Cannabis, immunity, and cognition—what’s the connection?

New research in people living with HIV shows that daily cannabis use is linked to an anti-inflammatory immune profile at the cellular level.

🔬 Key findings:
• Immune cells shift toward a less inflammatory, more energy-efficient state
• Increased mitochondrial activity and neuroprotective signaling (↑ BDNF)
• Reduced pro-inflammatory markers and improved systemic biomarkers
• Associated with better cognitive outcomes

💡 The takeaway:
Cannabis may help reprogram immune metabolism, potentially reducing neuroinflammation and supporting brain health in chronic conditions like HIV.

03/29/2026

is still framed as a disease of tissue. But what if it’s also a disease of signaling?

Yes, the endocannabinoid system ( ) also seems to be out of tune in ways that help lesions survive and make pain worse.

▶︎ Many women with endometriosis have different levels of endocannabinoids in their blood, especially higher and sometimes 2‑AG.
▶︎ In pelvic tissues, CB1 receptors (which usually help calm pain) are often reduced, while TRPV1 (a pro‑pain channel) is increased, pushing signals toward pain and inflammation.
▶︎ Inside the lesions themselves, CB1 and CB2 receptors are increased in the epithelial cells of endometriotic lesions compared with surrounding tissue.

Simply put:
▲ Outside the lesions: pain-calming ECS is turned down
▲ Inside the lesions: cannabinoid receptors are turned up
(!!!) This means that the lesions are packed with cannabinoid receptors, which means they are biologically “wired” to respond to cannabinoid‑type signals.

What this means for pain and symptoms
▶︎ Low CB1 + high TRPV1 = over-sensitive pain pathways and central sensitisation. This explains why pain can be excruciating and why anxiety, low mood, and poor sleep are so common alongside it.

What does this mean in practice?
▶︎ Because ECS dysregulation sits right on top of the core features of endometriosis, CB1/CB2 receptors and ECS enzymes are increasingly viewed as drug targets, not just interesting biology.
▶︎ Observational data suggest many patients are already self‑using cannabis or cannabinoid based products for symptom relief and report less pain and reduced use of other analgesics.

The question is no longer whether the ECS matters in endometriosis. It’s whether clinical medicine will catch up before another generation of women manages it alone.

This is the 5th post in a series examining women’s health through an ECS lens.
From migraine to endometriosis, from PCOS to IBS — each condition reveals a pattern: dysregulated ECS, overlooked by conventional medicine.

03/28/2026

Did you know?
• A significant portion of THC is metabolized in the liver into 11-OH-THC, a compound with potent central effects

• THC undergoes multiple metabolic steps before becoming THC-COOH, the main inactive metabolite

• These metabolites can persist in the body long after the clinical effects have subsided

Understanding THC metabolism is essential for clinicians navigating dosing, duration of effects, and patient variability.

As cannabinoid medicine evolves, so must our understanding of its pharmacokinetics and clinical implications 🌱

03/21/2026

03/20/2026

CBD Topical Medicine: What Does the Science Say?

From arthritis to skincare, scientists are beginning to uncover how topical CBD may reduce inflammation and pain — but more human studies are still needed.

03/15/2026

Two non-intoxicating compounds from cannabis just showed surprising potential against one of the
world’s fastest-growing diseases.
Researchers found that CBD and CBG may help combat fatty liver disease by boosting the liver’s energy
reserves and restoring its cellular cleanup systems.
Fatty liver disease affects roughly 1 in 4 adults globally. It occurs when fat accumulates in liver cells,
leading to inflammation, scarring, and eventually liver failure. There is currently no approved drug
treatment.
In the study, both CBD and CBG improved the liver’s ability to process fat and activated autophagy — the
cell’s natural recycling system that clears damaged components.
Importantly, neither compound caused the psychoactive “high” associated with THC. These are the same
compounds already used in many wellness products.
This is still early-stage research and not a recommendation to self-treat. But the results are promising
enough that clinical trials may follow.
The liver might have an unexpected ally.
Source: ScienceDaily, March 2026

03/13/2026

Cannabis is more than cannabinoids — terpenes play a key role too.
Terpenes are the aromatic compounds that give cannabis its distinctive smell and flavor, but they may also influence how cannabis interacts with the body.
Research suggests terpenes can contribute to the “entourage effect,” meaning they may work together with cannabinoids to shape therapeutic outcomes.
Some fascinating examples:

🍃 Myrcene – one of the most abundant cannabis terpenes, also found in thyme and mango; associated with analgesic and anti-inflammatory properties.
🌸 Linalool – the terpene behind lavender’s calming aroma, linked to sedative and anticonvulsant effects.
🍋 Limonene – found in citrus peels and certain cannabis cultivars; studied for mood-elevating and antimicrobial potential.
🌲 Pinene – responsible for the scent of pine forests; known for anti-inflammatory and bronchodilator properties.
🌶 Caryophyllene – unique among terpenes because it can interact with CB2 receptors in the endocannabinoid system.

As research advances, terpenes are becoming an essential part of understanding how cannabis may support patient care.

03/12/2026

🧠 Why is cannabis overdose considered extremely unlikely?

The answer lies in the brain.

The brainstem, which controls breathing and cardiovascular function, contains very few CB1 cannabinoid receptors. Because cannabinoids interact primarily with these receptors, they do not significantly suppress respiration.

In contrast, opioids act on receptors that are highly concentrated in the brainstem, which is why opioid overdose can stop breathing.

🌿 This difference in receptor distribution is a key reason why fatal overdose from cannabis alone has not been documented in scientific literature.
Understanding the endocannabinoid system helps clinicians better evaluate both the safety and therapeutic potential of cannabinoids.