EDS Zebra Articles

06/10/2026

2026 Age-related symptom clustering in pediatric hypermobility spectrum disorders: a scoping review

Background Pediatric generalized hypermobility spectrum disorders (pgHSD), are a group of multisystemic heritable connective tissue disorders frequently under-recognized in pediatric populations. The variable and often vague early symptomatology, coupled with the absence of definitive genetic marker...

06/10/2026

2026 Comorbidities in Ehlers-Danlos syndromes and hypermobile spectrum disorders

This journal only 2026, Number 2 > Acta Ortop Mex 2026; 40 (2) Comorbidities in Ehlers-Danlos syndromes and hypermobile spectrum disorders Wang, TJ1; Serrano-Ardila, AM2 Full text How to cite this article 10.35366/123052 DOI DOI: 10.35366/123052 URL: https://dx.doi.org/10.35366/123052....

06/08/2026

2026 Gastrointestinal involvement in Ehlers-Danlos syndrome classical-like type 2 associated with a novel AEBP1 splice-site variant

Ehlers-Danlos syndrome classical-like type 2 (clEDS2) is a rare autosomal recessive connective tissue disorder caused by biallelic loss-of-function variants in the gene encoding adipocyte enhancer-binding protein 1 (AEBP1). While cutaneous and skeletal manifestations are commonly observed, gastroint...

06/08/2026

2026 Autonomic Dysfunction Is a Key Feature of Hypermobile Ehlers-Danlos Syndrome and Other Complex Disorders with Chronic Fatigue

06/08/2026

2026 UK Medical Cannabis Registry: an updated analysis of clinical outcomes of medicinal cannabis therapy for hypermobility-associated chronic pain

Introduction/Objective The primary aim of this study was to evaluate changes in pain-specific and general health-related quality of life in individuals prescribed cannabis-based medicinal products (CBMPs) for hypermobility-associated chronic pain. Methods The case series utilised data from the UK Me...

05/26/2026

2026 Too high and too loose: dysautonomia and the hypertensive paradox in hypermobility disorders

Management of hypertension in hEDS/HSD requires adaptation of standard guidelines to accommodate dysautonomia-specific considerations, including withdrawal of provocative medications, avoidance of volume-depleting agents, and phenotype-directed pharmacotherapy. Long-term cardiovascular outcomes rema...

05/25/2026

2026 Esophageal Dysmotility and Gastroesophageal Reflux Disease Risk in Hypermobile Ehlers-Danlos Syndrome

05/22/2026

2026 Morphological and functional echocardiographic findings in pediatric patients diagnosed with hypermobile Ehlers-Danlos syndrome

IntroductionHypermobile Ehlers-Danlos syndrome (hEDS) is a connective tissue disorder that may involve the cardiovascular system. While mitral valve prolapse...

05/22/2026

2026 Recurrent massive hematoma after trivial trauma in Ehlers–Danlos syndrome: a case report highlighting diagnostic urgency and surgical challenges

Musculocontractural Ehlers–Danlos syndrome (mcEDS) is a rare connective tissue disorder characterized by abnormal collagen structure, tissue fragility, and predisposition to disproportionate hematoma formation following trivial trauma. Large ...

05/22/2026

2026 Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Mentored Review

Gastroenterologists should maintain a high index of suspicion for hEDS/HSD, which can be readily screened for using the Beighton score. Earlier diagnosis may be therapeutic by reducing uncertainty related to multisystem symptoms. A multidisciplinary approach incorporating mental health, nutrition, a...