EDS Zebra Articles

08/27/2026

2026 Defining Neuro-EDS: A Neuro-Predominant Phenotype in hEDS/HSD and Related Heritable Connective Tissue Disorders

A subgroup of patients with hypermobile Ehlers–Danlos syndrome (hEDS), hypermobility spectrum disorders (HSD), and related heritable connective tissue disorders develop complex neurological manifestations that extend beyond generalized joint hypermobility and musculoskeletal involvement. Although ...

08/17/2026

2026 Emerging Clinical Concepts in Pain Management of Ehlers-Danlos Syndrome

08/17/2026

2026 Surgical Decision‐Making in the Setting of Diagnostic Uncertainty in Upper Extremity Subcutaneous Emphysema

Background Necrotizing soft tissue infections (NSTIs) are life-threatening and require emergent surgical debridement. Benign subcutaneous emphysema is a rare, noninfectious condition characterized b...

08/17/2026

2026 Familial Chiari Malformation: Prevalence of Connective Tissue Disorders and Other Comorbidities

Familial CM-I is strongly associated with CTDs, particularly EDS, and systemic comorbidities such as hypermobility, postural orthostatic tachycardia syndrome, and mast cell activation disorder. These findings support a heritable link between CM-I and CTDs and highlight the importance of detailed fam...

07/24/2026

2026 Pain, Sleep Latency, and Mental and Physical Health in Individuals with Self-Reported Hypermobile Ehlers-Danlos Syndrome

Background: Individuals with hypermobile Ehlers–Danlos syndrome (hEDS) frequently report chronic pain, sleep-related complaints, and reduced mental and physical health. While sleep disturbance has been described in this population, less is known about how pain frequency relates to sleep initiation...

07/24/2026

2026 Linking central sensitization to multisystemic manifestations in hypermobile Ehlers-Danlos syndrome

Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) are complex multisystemic conditions frequently associated with chronic ...

07/24/2026

2026 Combined Mutations of LTBP3 and COL5A1A in Geleophysic Dysplasia

Geleophysic dysplasias (GDs) are uncommon genetically predisposed abnormalities that interfere with skeletal growth and formation. Several GD subtypes have different clinical manifestations. The curr...

07/24/2026

2026 Characterizing sexual dysfunction in females with hypermobile Ehlers Danlos syndrome or hypermobility spectrum disorder and genito-pelvic pain through cross-sectional analysis

Hypermobile features are common among patients presenting for genito-pelvic pain.

07/24/2026

2026 Coronary thrombosis after Bentall's procedure in a patient with Ehlers-Danlos syndrome: a case report

Background Acute coronary syndrome (ACS) following cardiac valve replacement is a rare but severe complication. Patients with vascular Ehlers-Danlos syndrome (vEDS) may exhibit an increased propensity for coronary thrombosis due to their genetic predisposition. After Bentall surgery, coronary manipu...

07/23/2026

2026 Splicing Alterations Associated with Multiple Homozygous TNXB Variants in a Patient with Suspected Classical-Like Ehlers-Danlos Syndrome

Ehlers–Danlos syndrome (EDS) comprises a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Classical-like EDS (clEDS) is typically associated with pathogenic biallelic variants in TNXB. The patient show...