Save Your Thyroid with Jen

Save Your Thyroid with Jen Podcaster, Founder of Save Your Thyroid https://linktr.ee/itsme_jenagain

"We are not burning tissue. We are programming cells to die."Professor Stefano Spiezia on the science behind nsPFA — sho...
09/11/2026

"We are not burning tissue. We are programming cells to die."

Professor Stefano Spiezia on the science behind nsPFA — short electrical pulses trigger a natural, regulated cell death instead of using heat to destroy the nodule.

Episode 127: nsPFA: Zero Regrowth at 22 Months! The Durability Data Thyroid Patients Need — Save Your Thyroid with Jennifer Holkem, available on all podcast platforms! Link in the comments.

09/10/2026

Regrowth is always on the minds of patients considering any thyroid nodule treatment. So I asked Professor Spiezia directly: if nsPFA nodules did regrow down the road, could the procedure be repeated safely?

"That was what we observed in this first durability study. And this is one of the advantages of this approach. We didn't observe any regrowth because nsPFA does not induce significant fibrosis. The tissue remains more treatable over time. So if regrowth were to occur, in principle, the procedure could be repeated safely."

That's not a small detail. It means more flexibility in long-term management of your nodules, not a one-shot treatment with limited options if things change later.

Episode 127: nsPFA: Zero Regrowth at 22 Months! The Durability Data Thyroid Patients Need — Save Your Thyroid with Jennifer Holkem.

"If RFA was a revolution, nsPFA is a paradigm shift."Professor Stefano Spiezia on why nsPFA isn't just another ablation ...
09/09/2026

"If RFA was a revolution, nsPFA is a paradigm shift."

Professor Stefano Spiezia on why nsPFA isn't just another ablation option — it works through a completely different biological mechanism than heat-based treatments like RFA.

Episode 127: nsPFA: Zero Regrowth at 22 Months! The Durability Data Thyroid Patients Need — Save Your Thyroid with Jennifer Holkem, available on all podcast platforms! Link in the comments.

09/08/2026

Here's something that changes the calculus for anyone worried about needing a second treatment down the road.

Traditional thermal ablation (RFA, microwave) destroys tissue with heat — which means destroying not just the nodule, but the surrounding structure too. That's what causes fibrosis, the scarring that forms after treatment.

"With nsPFA, the extracellular matrix is largely preserved because there is no thermal damage. This results in minimal fibrosis."

Professor Stefano Spiezia explains why that matters clinically: better healing, preserved anatomy, and — if a nodule were to ever regrow — a much easier path to re-treatment than with typical thermal ablation.

Fibrosis isn't just a cosmetic concern. It's the difference between a straightforward second procedure and a complicated one.

Episode 127: nsPFA: Zero Regrowth at 22 Months! The Durability Data Thyroid Patients Need — Save Your Thyroid with Jennifer Holkem.

This Week on Save Your Thyroid with Jennifer Holkem: Professor Stefano Spiezia"If RFA was a revolution, nsPFA is a parad...
09/07/2026

This Week on Save Your Thyroid with Jennifer Holkem: Professor Stefano Spiezia

"If RFA was a revolution, nsPFA is a paradigm shift."

That's how Professor Spiezia describes the newest development in non-surgical thyroid treatment — and this week, he's back on the podcast with data this community has been waiting for.

Professor Stefano Spiezia is the head of the Division of Endocrine and Ultrasound Guided Surgery at the Sea Hospital in Naples, Italy, and Director of the Regional Reference Center for Thyroid Treatment there. He's an adjunct professor of minimally invasive percutaneous thyroid treatments at the University of Turin, a pioneer in thermal ablation of thyroid nodules in Europe, and the director of the Save Your Thyroid International School for Interventional Thyroid Procedures.

TOMORROW on Save Your Thyroid with Jennifer Holkem, Professor Spiezia joins me to share the 22-month durability data on nsPFA, presented at the 2026 NASIT meeting in Portland.

Why this episode is a must-listen:
👉 Zero nodule regrowth across 15 to 22 months of follow-up
👉 74% average volume reduction, with no serious adverse events
👉 Why nsPFA nodules keep shrinking over time instead of plateauing
👉 100% of patients highly satisfied with cosmetic results; 95% satisfied overall
👉 Why no heat means no fibrosis — and what that means for re-treatment
👉 Why nsPFA may reach nodules and cancers too close to nerves for heat-based treatment

Episode drops TOMORROW. Link in the comments. 👇

"It's okay to be scared. But you should know the odds are genuinely in your favor."If you're reading this at 1 a.m. with...
09/06/2026

"It's okay to be scared. But you should know the odds are genuinely in your favor."

If you're reading this at 1 a.m. with a biopsy date on the calendar — this one's for you.

I'm not going to tell you to calm down. That never helped me either. The fear is real and it deserves to be taken seriously.

But fear and facts can sit in the same room. And the facts here are so much kinder than the story your brain is writing tonight.

Most nodules are benign. Most people are fine. And almost nobody in this situation has to decide anything tomorrow.

You have more time than you feel like you have. Use it to get informed, not to spiral.

Ep. 126: Just Diagnosed With a Thyroid Nodule? What They Don't Tell You on Day One

Full episode and our community in the first comment.

09/05/2026

For months, I couldn't lie flat.

I choked on food. I woke up choking. I got dizzy when I turned my head. I was exhausted in a way sleep didn't fix — which I'd later learn was actual hypoxia. My body wasn't getting enough oxygen.

I used to describe my quality of life during that stretch as being in the garbage. That's not me being dramatic. It's the most accurate description I have.

The nodule the ENT shrugged off — the one he said we could take out or leave alone, "whatever" — had grown to roughly 4.5 by 7 centimeters. Then I had an allergic reaction to an antibiotic, the nodule hemorrhaged internally, and it had nearly doubled in size overnight.

That's when I finally went looking for something other than take it out or leave it alone.

I found radiofrequency ablation. I had the procedure and went home the same day. Within a week, my quality of life had already improved dramatically. Over the following months the nodule shrank by 90%. My thyroid stayed intact. My raspy voice improved.

The procedure changed my life. It's the reason I do this.

Ep. 126: Just Diagnosed With a Thyroid Nodule? What They Don't Tell You on Day One

Save Your Thyroid with Jennifer Holkem. Now available on ALL major podcast platforms!



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"A thyroid nodule diagnosis does not automatically mean surgery."I need more people to hear this before they schedule an...
09/04/2026

"A thyroid nodule diagnosis does not automatically mean surgery."

I need more people to hear this before they schedule anything.

Surgery is an option. For some people it's the right one. But it is not the only one, and it is not automatically yours.

There's a whole menu — and most patients never get shown it. They get a referral, a surgeon's name, and the quiet impression that the decision has already been made for them.

It hasn't. Not usually. Not on day one.

You are allowed to ask what else is on the table before you agree to anything.

Ep. 126: Just Diagnosed With a Thyroid Nodule? What They Don't Tell You on Day One

Full episode and our physician finder — specialists in 50+ countries — in the first comment.

09/03/2026

No incision. Outpatient. Home the same day.

I want to describe what that actually looks like, because most people have never been told it exists.

A probe goes through the skin — no cutting, no scar — and treats the nodule directly. You go home that afternoon. Your thyroid stays where it is.

That's radiofrequency ablation. There's also microwave ablation and other non-surgical techniques. And for plenty of people, the right answer is active surveillance — regular ultrasounds and nothing else unless something changes.

Which one fits depends on the size, your Bethesda category, your symptoms, and how the nodule is actually behaving. Not every option is right for every person, and none of this replaces your own physician's read on your scans.

But a thyroid nodule diagnosis — and even some cancer diagnoses — does not automatically mean surgery. It doesn't mean losing your thyroid. It doesn't mean a scar, a lifetime of hormone replacement, and a recovery you never agreed to.

If nobody has walked you through what else exists, that's the gap this episode is trying to close.

Ep. 126: Just Diagnosed With a Thyroid Nodule? What They Don't Tell You on Day One

Save Your Thyroid with Jennifer Holkem. Now available on ALL major podcast platforms!

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