Waypoint Medical - Weight Loss and Metabolic Health

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Waypoint Medical - Weight Loss and Metabolic Health

Waypoint Medical is a concierge, high-touch telehealth weight loss practice in Missouri, founded by Katie Chambers, PA-C. MO residents only.

Evidence-based GLP-1 care, no stigma, no judgment. Free intro call to start.

27/08/2026

This data seems counterintuitive. You’d think anyone starting a GLP-1 would be moving more, not less. But the numbers don’t lie, and they’re showing a weird dichotomy in GLP-1 care right now.

New research out of ENDO 2026 tracked real Fitbit data on almost 2,000 people with obesity who started a GLP-1. Daily steps dropped from 5,047 to 4,487. Moderate to vigorous activity dropped 21%, from 28 minutes a day down to 22. Men and people with joint or muscle pain had the steepest declines.

Yet, here is what I see in my practice. My patients steps and exercise are going up. My suspicion with this study is that these people weren’t getting the same 1:1 care and accountability that my patients are getting. And we already know from other research how much that support matters for actually keeping the results you’re working for.

GLP-1s work. What you build around them is what decides whether you keep muscle or lose it along with the fat. That’s why my patients get body composition tracking, a real activity plan, and accountability built around the medication instead of separate from it.

Link in bio if you want to build that plan.

26/08/2026

Happy hump day y’all! 🐪
Get out there and crush your goals today. You got this 💪

25/08/2026

Yes I’m giving you the correct answer, no gatekeeping here, but comment below your answer before you keep reading!

When evaluating these patients, it’s important to remember that research consistently shows somewhere between 20 and 30% of the weight lost on these GLP-1 medications is lean mass. Not fat, but muscle and organ tissue, which is of course the stuff you want to keep.

It’s a well known thought that individuals on Tirzepatide lose more absolute lean muscle mass because they are losing overall more weight in general. But we have to remember that medication is not the whole picture.

A preprint electronic health review released this year looked at real patient data and found that reduced exercise tolerance was the strongest predictor of lean mass loss, stronger than which drug someone was on. New joint pain, especially knee pain, was the second strongest predictor. This hasn’t gone through peer review yet, so I’m not treating it as gospel, but it lines up with exactly what I see in my own patients week to week.”

Also important to note is a study presented at ENDO 2026 that tracked Fitbit data on 753 patients starting GLP-1 therapy. They found that daily steps dropped from an average of 5,047 to 4,487, a loss of over 500 steps a day, and moderate to vigorous activity minutes fell from about 28 minutes to 22 minutes daily. Both changes were statistically significant. And in that same cohort, nearly 82% already had musculoskeletal pain at baseline. I suspect that this happens because of energy decrease due to appetite changes and no one monitoring these changes to ensure there is not impact on activity level.

So when we compared these two patients, who’s profiles on paper are very similar, we have to make note of how Patient B’s increasing knee pain will impact her ability to continue to exercise and strength train.

These are the kinds of things that get missed if you are talking to a provider regularly who knows how to monitor for the small details of GLP-1 medications and weight loss.

Did you get this one right? Let me know in the comments what you thought.

Address

1600 Heritage Landing Suite 108B
MO
63303

Telephone

+16365791729

Website

https://www.waypoint-medical.com/, http://www.waypoint-medical.com/call, http://www.waypoint-medical.com/workoutprompt,

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