10/24/2026
Bone healing depends on more than a cast, brace, or surgery. This meta-analysis found that smokers had substantially higher odds of nonunion than nonsmokers.
This is a classic OFM example of why chemistry and healing capacity matter. The biologic environment can strongly influence how well tissue recovers, and smoking status should absolutely be part of the orthopedic conversation.
Reference
Patel RA, Wilson RF, Patel PA, Palmer RM. Do smokers have greater risk of delayed and non-union after fracture, osteotomy and arthrodesis? A systematic review with meta-analysis. BMJ Open. 2016;6(11):e010303. doi:10.1136/bmjopen-2015-010303.