07/26/2026
How does ฮฒ-caryophyllene affect muscles?
In addition to its immunomodulatory effects, CB2 directly influences skeletal muscle metabolism. Activation by agonists such as ฮฒ-caryophyllene enhances glucose uptake, stimulates glycolytic and oxidative pathways, increases ATP production, and promotes lipid oxidation via SIRT1/PGC-1ฮฑ signaling in myotubes [69]. These metabolic effects align with mechanistic evidence identifying CB2 as a positive regulator of energy metabolism, muscle cell growth, and regeneration. Collectively, current evidence demonstrates that CB2 integrates immune and metabolic signaling to limit inflammation and fibrosis while promoting efficient muscle repair. These findings highlight its potential as a therapeutic target for muscle disorders characterized by chronic inflammation, degeneration, and metabolic dysfunction.
Endocannabinoid system and skeletal muscle health: Insights from cannabidiol...doi: 10.1016/j.molmet.2026.102396