ESSI Fertility & Immunology

ESSI Fertility & Immunology 🧪Exploring the science of life 🧬, from reproductive biology to immune health 🧫.
🔬Research updates
& 📚educational insights by ESSI 👩🏼‍🔬

May is Celiac Disease Awareness Month 🌾💚Untreated celiac disease may be associated with:• unexplained infertility• recur...
05/14/2026

May is Celiac Disease Awareness Month 🌾💚

Untreated celiac disease may be associated with:
• unexplained infertility
• recurrent pregnancy loss
• irregular cycles
• nutrient deficiencies

Researchers believe chronic inflammation, autoimmune activity, and nutrient malabsorption may play a role.

Awareness matters. đź’š

Most people think endometriosis begins when symptoms appear.But what if some risk factors begin years earlier?A new Fert...
05/13/2026

Most people think endometriosis begins when symptoms appear.

But what if some risk factors begin years earlier?

A new Fertility & Sterility study followed 11,773 girls and young women for over 25 years and found associations between adolescent disordered eating behaviors and later endometriosis diagnosis.

This does NOT prove causation.

But it raises important questions about how hormonal, inflammatory, and metabolic changes early in life may intersect with endometriosis risk years later.

Endometriosis may be far more systemic than we once believed.

What are your thoughts on these findings?

Study:
Thornburgh et al.
Fertility & Sterility, 2026

Follow .FertilityImmunology for evidence-based endometriosis & fertility insights.

S*x “tricks” to get pregnant?You’ve heard them:– stay lying down– don’t go to the bathroom– certain positions work bette...
04/28/2026

S*x “tricks” to get pregnant?

You’ve heard them:
– stay lying down
– don’t go to the bathroom
– certain positions work better

But most of these don’t meaningfully change your chances.

S***m reach the cervix within minutes.
Ovulation, not technique, defines the window.

And if it’s not happening, it’s rarely about “doing s*x wrong.”

The answer is often deeper:
egg quality, s***m function, endometriosis, hormones, immune factors.

That’s where the real conversation starts.

đź’¬ Which one have you been told?

đź“š References:

* American Society for Reproductive Medicine, 2017
* Roy Levin, 2003
* Allen J. Wilcox, The New England Journal of Medicine, 1995
* Ashok Agarwal, 2008

We test embryos.But we don’t test the whole embryo.A 2024 study using single-cell sequencing showed that early human emb...
04/25/2026

We test embryos.
But we don’t test the whole embryo.

A 2024 study using single-cell sequencing showed that early human embryos are often genetically heterogeneous, meaning different cells within the same embryo can carry different chromosomal profiles (mosaicism).

This matters because PGT-A analyzes a small biopsy of cells, not the entire embryo.

So the result you receive is a representation of that sample, not a complete map of the entire embryo

This does NOT change clinical reality:
Euploid embryos still have the highest implantation and live birth rates.

But it does reinforce something critical:
Embryos are not binary systems.
They are complex, dynamic biological structures.

At ESSI, interpretation goes beyond the label, it’s about understanding the full clinical and biological context.

How do you interpret your embryo results?

Zhai et al., 2024 – Cell Discovery (PMC11420220)

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