Yuliya Mikhael

Yuliya Mikhael OB-GYN Consultant/ Pregnancy&Delivery/Aesthetic Gynecology/Fetal Medicine/Laser

There is a “new kid on the block” for treatment of PMOS (formerly known as PCOS) : it is Resveratrol -natural polyphenol...
10/06/2026

There is a “new kid on the block” for treatment of PMOS (formerly known as PCOS) : it is Resveratrol -natural polyphenol found in grapes, red wine and berries.
Available in form of a supplement.

It was found to lower circulating androgens and combat insulin resistance
- the key features of PMOS.

WHY IS IT SO IMPORTANT?

- women suffering from PMOS(PCOS), often have overproduction of androgens - causing nasty symptoms like oily skin, acne, excessive facial hair and scalp hair thinning.
- Not too many natural options exist to mitigate these symptoms. Resveratrol does it.
- PMOS(PCOS) is a chronic condition, so, avoiding longterm “standart”medications, like birth control pills, in favour of more natural supplement without side effects sounds like a great alternative.

HOW ABOUT THE DOSE?

- randomized study on resveratrol and PCOS [PMID: 37333786] found that 1,500 mg /day of resveratrol significantly improves hormonal imbalances and metabolic function.
- ‼️that is much higher than usual dose of Resveratrol used for longevity protocols - 170-300 mg.

IS IT POSSIBLE TO SOURCE OT FROM FOOD?

- No, it is not possible to get the required resveratrol amount from diet:

* Red wine contains only 0.05 -1 mg per glass
* 1-cup (150g) of red grapes contains only 0.24 to 1.25 milligrams (mg) of resveratrol
* Only 0.03-0.1 mg per 100 grams (1/2 cup) of fresh blueberries.

As you may know many HRT preparations for hormone optimisation are made for transdermal ( via skin) application. Transde...
04/06/2026

As you may know many HRT preparations for hormone optimisation are made for transdermal ( via skin) application.

Transdermal forma are usually much safer and help to reduce the risk of abnormal blood clotting.
But what are the best ways to use them?

‼️first of all - make sure to read carefully the label and understand what is your dosage - how many pumps or clicks you need to use to receive the correct dose.

BEST AREAS TO APPLY HORMONAL CREAM:

- Inner surface of the forearms
- Inner surgace of the thighs
- Lower abdomen
- Lateral sides of the abdomen (Flanks)
- Behind the knee
- inner surface if the arms
- Vaginal (see below about testosterone!)
🔹Rotate sites for better absorption.
🔹Women with who worry about medication transfer to the partner or kids:
- apply the cream behind the knees, on inner thigh, and lower abdomen
- avoid direct skin-to-skin contact after the application until 4-6 hrs later.

WHICH AREAS TO AVOID WHILE APPLYING HRT CREAM?

- Face and neck (unless you are using estriol creams for specific indications)
- Breasts
- Skin that is broken or irritated
- Do not apply right before workouts, sauna, or swimming - allow 1-2 hours for proper absorption.

‼️Important for testosterone cream:

🔹applying topical testosterone too close to cl****al tissue can increase the risk of cl****al enlargement - avoid this route unless there is specific instruction.
🔹Just because a hormone is applied vaginally does NOT mean it stays local. Vaginal hormones can still make systemic effect.

You have heard about DEXA scan as an option to asses your bone density so to understand - whether or not you have osteop...
25/05/2026

You have heard about DEXA scan as an option to asses your bone density so to understand - whether or not you have osteoporosis /osteopenia.

IS DEXA SCAN ENOUGH TO STUDY OSTEOPOROSIS?

🦴Actually, no, there is much more to that. To decide about good strategy for your bones health optimization we need to dig more.
There are special blood markers that help us understand what is actually going on in our bones tissue:

* P1NP measures bone-building activity (by the cells called « osteoblasts »).
* CTX measures bone resorption or breakdown (by the cells called « osteoclasts »).

🦴To understand which process is currently dominating in your bones we need to know P1NP / CTX ratio.

🦴The P1NP/CTX ratio can evaluate bone health by comparing bone formation to bone breakdown.

WHAT IS THE IDEAL RATIO?

🦴 P1NP/CTX ratio >150 indicates a healthy dominance of bone building over breakdown. This value is recommended by functional medicine practitioners and bone health specialists as a target.

🦴If you have been diagnosed with with osteoporosis or osteopenia - it is highly recommended recommended to measure your P1NP/CTX ratio to figure out best treatment option.

🦴If you are taking bone-building medications (like Forteo or Tymlos) or anti-resorptive drugs (like Fosamax or Prolia), your markers will change dramatically - it may be required to test them from time to time.

For accurate measurements, these blood tests must be dine in the morning on fasting state - as bone turnover markers are highly sensitive to food and time of day .


📌« Whooping cough » (or, coqueluch, or, pertussis) is potentially serious disease that can affect newborn baby during fi...
04/05/2026

📌« Whooping cough » (or, coqueluch, or, pertussis) is potentially serious disease that can affect newborn baby during first few months of life.

IS WHOOPING COUGH COMMON?

📌the incidence of whooping cough cough in UAE is low (only 9 cases reported in 2019), however the disease can be severe, sometimes causing severe complications or even death.

WHY TO CONSIDER VACCINE DURING THE PREGNANCY ?

📌Newborn babies are at the highest risk since they cannot receive their own vaccine until they are 2 months old.

📌vaccination during pregnancy is highly recommended as the most effective ways to protect a newborn from a potentially fatal disease.

📌 When pregnant woman receives the vaccine, her body produces antibodies - they cross the placenta and transfer to the baby, offering immune protection immediately after the birth.

📌Vaccinating the mother during pregnancy reduces the risk of pertussis in young children by 80–91%.

WHEN TO GET THE VACCINE?

📌ideal time is between 26 -32 weeks of pregnancy (can be given as early as 16 weeks up until delivery).

IS IT NECESSARY TO VACCINATE IN NEXT PREGNANCY?

📌yes, it s better to receive the vaccine during each pregnancy, even if they are close together, to make sure the baby receives maximum antibodies.

IS IT SAFE?

📌 Pertussis vaccine does not contain live bacteria (contrary to other vaccines, like e.g. chickenpox) and has been proven safe for both - mom and baby.

Many of my patients asked me - does IVF increase breast cancer risk? The short answer is “NO”: 📌Few large studies follo...
14/04/2026

Many of my patients asked me - does IVF increase breast cancer risk?

The short answer is “NO”:

📌Few large studies followed many thousands of women that underwent multiple IVF over 20 years -> they showed NO increased risk of breast cancer, even after six or more IVF cycles.

📌interestingly, some research showed that having >7 IVF stimulation cycles is associated with LOWER cancer risk.

HOW ABOUT OVARIAN CACER?

📌for ovarian cancer, a big study in >40,000 women found no increased risk of ovarian cancer related to IVF.

‼️Borderline (precancerous)ovarian tumors: studies slightly higher risk - with NOT aggressive tumor biology, excellent prognosis, tha usually required surgery only for the treatment.

CONCLUSION?

📌Multiple IVF cycles do NOT increase breast or ovarian cancer risk.
📌Standard screening (annual trans vaginal pelvic ultrasound) is sufficient for most women.

WHAT ARE SPMs? When you get injury or infection, your body responds by sending in “first responders” -your white blood c...
30/03/2026

WHAT ARE SPMs?

When you get injury or infection, your body responds by sending in “first responders” -your white blood cells- to fight the damage.

As we know know, inflammation does not fade away on its own- it is an active process. After finishing initial «attack » the body goes into “cleanup mode”.

Specialized Pro-Resolving Mediators (SPMs)- are compounds produced naturally by our body to put an end to inflammation and start tissue repair. 

SPMs are like a “cleanup team”, the “janitors”, that work with immune system to fight off an infection or injury. 

SPMs tell the «first responders» to stop fighting and leave, and instruct the «cleanup cells» (macrophages) to eat up debris and dead cells. 

HOW ANTI-INFLAMMATORY MEDICATIONS ARE DIFFERENT FROM SPMs?

* Anti-inflammatories (e.g., Ibuprofen, Advil): block inflammation, without helping the repair process.
* Pro-Resolving Mediators ( SPM): actively end the « fight», clear the mess, and initiate tissue repair. 

HOW OUR BODY SOURCES SPMs?

SPMs are made from mainly the Omega-3 fatty acids (EPA and DHA) found in fish oil.

THERE ARE 4 TYPES OF SPMs:

1. Resolvins: made from EPA and DHA (Omega-3).
2. Protectins: made from DHA (Omega-3).
3. Maresins: made from DHA (Omega-3).
4. Lipoxins: made from Arachidonic Acid (Omega-6). 

WHY SPMs ARE SO IMPORTANT ?

When our body doesn’t produce enough SPMs, acute inflammation continues, leading to chronic inflammation.

This is usually the case with conditions such as arthritis, heart disease, Alzheimer’s, and diabetes. 

CAN YOU TAKE THEM AS SUPPLEMENTS?

Yes, although, the good diet should ne the main source of SPMs, taking them as supplements can help to treat chronic inflammation.

HOW TO COPE WITH STRESS DURING THE TIMES OF UNCERTAINTY ? Uncertainty is a powerful emotion that often is accompanied by...
23/03/2026

HOW TO COPE WITH STRESS DURING THE TIMES OF UNCERTAINTY ?
Uncertainty is a powerful emotion that often is accompanied by stress, feeling of being lost and out of control.

HOW TO COPE WITH UNCERTAINTY ?

The rational analysis of the current situation is very helpful as well as focusing on the present, accepting what cannot be control, and maintaining healthy routines.

WHAT ELSE CAN HELP?

- limit exposure to the news (especially in photo/video format)
- Work out regularly
- Spend time in nature or with pets
- Practice active relaxation (controlled breathing, yoga, meditation, journaling..)
- Listen to binaural beats (headphones required)
- connect with your support network - family, friends , community, co-workers
- consider using vagus nerve stimulating device ( e.g. Nurosym)
- Take good quality magnesium supplement (glycinate, treonate)
- Try adaptogens (ashwagandha) to reduce stress toll on your body
- Practice gratitude daily and be positive

Lipid profile is one of the standard baseline blood tests that is done for men and women to screen them for cholesterol ...
17/03/2026

Lipid profile is one of the standard baseline blood tests that is done for men and women to screen them for cholesterol issues. It measures LDL ( «bad» cholesterol linked to heart disease and stroke) and HDL («good» cholesterol know to be protective for the arteries).

It is well known fact that women in menopause often have increase in their «bad» cholesterol (dyslipidemia). But do they always need to take statins ? the medications to lower LDL- as these medications are not without their side effects.

One of the good ways to figure it out is to check ApoB:

WHAT IS APO B?

🫧Apolipoprotein B (or, ApoB) is a protein that transports « bad » cholesterol in your blood.
🫧ApoB is like a «vehicle» that carries little «bad fat» particles (LDL ,VLDL) within the blood vessels. Without the « vehicle» LDL is unable to reach the arteries.
🫧ApoB also makes «bad fat» particles to stick to the walls of the arteries, creating plaques. 
🫧checking ApoB gives more accurate estimation of the whole «cholesterole issue» since it measures not just the total amount of fat, but number of particles that actually cause damage to the arteries. 
🫧the higher is ApoB level - the more is the quantity of the «vehicles » transporting dangerous fat to form the plaques, increasing the risk of heart disease.
🫧 ApoB is important when we want to decide about whether or not to take the statin medications.

WHAT ABOUT THE NUMBERS?

🫧ELEVATED LEVEL OF APO B: >100 - means the plaques formation is progressing
🫧ACCEPTABLE LEVEL OF APO B: 70-80 - means that plaques formation slows down
🫧GOOD LEVEL OF APO B: 60-70 - plaques progression stops
🫧OPTIMAL LEVEL OF APO: 50-60 - plaques can be reversed

HAPPY INTERNATIONAL WOMEN ‘s DAY! To all amazing women i had the chance to cross in my life - beautiful, independent, c...
08/03/2026

HAPPY INTERNATIONAL WOMEN ‘s DAY! To all amazing women i had the chance to cross in my life - beautiful, independent, caring, intelligent, strong, funny, professional, wise, resilient - you are the BEST PART OF THE WORLD ! 🤍🤍🤍🤍🤍

FINALLY- BIRTH CONTROL PILL FOR MEN? 🔹Yes, you read ot right- a non-hormonal male birth control pill 💊 had been newly de...
17/02/2026

FINALLY- BIRTH CONTROL PILL FOR MEN?

🔹Yes, you read ot right- a non-hormonal male birth control pill 💊 had been newly developed - its called YCT-529.

HOW DOES IT WORK?

🔹it prevents s***m development by blocking vit A metabolite that is instrumental for s***m production.
🔹since the pill in non-hormonal, It does not lower testosterone, mood, or libido.
🔹YCT-529 technically blocks the retinols receptor alpha (RAR-a) in the testicular tissue , a protein crucial for vit A signaling necessary for s***m development.

ARE THERE ANY SIDE EFFECTS? IS IT REVERSIBLE?

🔹The effect is reversible, meaning when man stops taking this pill he can be fertile again.
🔹There are no any hormonal side effects
🔹for now, there are only two contraceptive methods for men: 1) condoms (~13% failure) or 2)vasectomy (irreversible).
🔹the verdict: YCT-529 is a safe, reversible option oral pill, with no apparent side-effect.

IS YCT-529 AVAILABLE IN THE PHARMACY?

🔹not yet, the pill is still under trial, to make sure that longer intake (up to 90 days) is safe and effective .

Contraceptive for men. Birth control. Family planning. Safe contraception.

Address

Dubai

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Monday 09:00 - 17:00
Tuesday 09:00 - 17:00
Wednesday 09:00 - 17:00
Thursday 09:00 - 17:00
Sunday 09:00 - 17:00

Telephone

+97144542640

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