02/10/2026
Does this new study mean we should start using IgG food intolerance tests for IBS? 🩸
The results are interesting, and I don’t think they should simply be dismissed.
But showing that an IgG-guided elimination diet improved one outcome does not prove that IgG has correctly identified someone’s food intolerances.
There are still some big unanswered questions, particularly around differences in FODMAP and fibre intake between the diets, whether IgG positivity actually identifies a symptom-triggering food, and what happens when those foods are reintroduced.
This matters because unnecessary food restriction isn’t harmless. With IBS, our goal should be to identify what actually triggers YOUR symptoms while keeping your diet as varied as possible.
So yes, this study has made the IgG conversation more interesting.
But no, I’m not recommending IgG testing to guide food elimination in IBS based on the evidence we currently have.
📚 REFERENCES:
1. Singh P et al. Gastroenterology. 2025.
Food-specific IgG-guided elimination diet in IBS.
PMID: 39894284
2. Atkinson W et al. Gut. 2004.
Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial.
PMID: 15361495
3. Vasant DH et al. Gut. 2021.
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome.
PMID: 33903147
4. Stapel SO et al. Allergy. 2008.
Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report.
PMID: 18489614
Important distinction: the EAACI paper specifically discusses food-specific IgG4, a subtype of IgG. The newer IBS trial measured food-specific IgG.
FODMAP