07/10/2026
Scientists have uncovered microbiome patterns shared across cancers and unique to specific tumor types.
A new study, published in Cell, has identified shared microbiome alterations across cancers and detected specific microbial signatures for certain cancer types.
By comparing species, pathway, and co-abundance group abundance between the healthy controls and individual cancer types, the researchers found that the altered species and pathways across cancer classes overlapped—44 species and 13 pathways were shared in 90.2% of cancer classes.
Elevated Blautia-Streptococcus and reduced
Faecalibacterium-Dorea co-abundance groups were also consistent features across 21 out of 22 cancer types.
After comparing each cancer type's microbial signature and accounting for potential confounding factors, including common cancer comorbidities, the authors found significant associations with specific microbial species in five cancer types: neuroendocrine tumors, liver and intrahepatic bile duct cancer, lymphoid leukemia, esophageal cancer, and multiple myeloma.
For example, neuroendocrine cancer exhibited a broad loss of health-associated microbiome species and a higher abundance of the Enterobacteriaceae, Streptococcaceae, and Veillonellaceae families.
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