Centenary Institute

Centenary Institute We are at the forefront of medical research, solving the greatest health problems facing our community.

🫀 Helping damaged hearts heal 🫀Congratulations to Centenary’s Associate Professor Daniel Hesselson who has received a ma...
02/06/2026

🫀 Helping damaged hearts heal 🫀

Congratulations to Centenary’s Associate Professor Daniel Hesselson who has received a major NSW Health research grant to advance work focused on regenerating heart muscle lost after a heart attack.

By combining AI, protein engineering and regenerative medicine, the research aims to develop new therapies that could help restore heart function and improve outcomes for patients living with cardiovascular disease.

Read more: https://www.centenary.org.au/news/regenerative-focused-research-grant-to-repair-and-restore-damaged-hearts/

Justin Clancy MP visits Centenary InstituteThis week, the Centenary Institute hosted Justin Clancy MP, Shadow Minister f...
27/05/2026

Justin Clancy MP visits Centenary Institute

This week, the Centenary Institute hosted Justin Clancy MP, Shadow Minister for Medical Research, for a briefing on our current research initiatives and a tour of our laboratory facilities.

It was a fantastic opportunity to share our vision for the future as well as present our work in several critical health areas including:

• Sudden cardiac death in young people – exploring how genetic testing and clinical care can help provide answers for families and support prevention strategies

• Protein design – using new technology to rapidly design and improve proteins for use in potential new treatments, including type 1 diabetes

• Melanoma research – advancing immunotherapy techniques to better detect and treat skin cancer

Thank you, Mr Clancy, for engaging with our researchers and for your interest in Centenary’s breakthrough work to tackle disease, develop new treatments and save lives.

Read more: https://www.centenary.org.au/news/justin-clancy-mp-visits-centenary-institute/

🩸Centenary research aims to improve diagnosis of heavy menstrual bleeding 🩸The Centenary Institute is implementing a new...
21/05/2026

🩸Centenary research aims to improve diagnosis of heavy menstrual bleeding 🩸

The Centenary Institute is implementing a new research program to better understand heavy menstrual bleeding and improve diagnosis and care for women affected by the condition.

Heavy menstrual bleeding affects around 1.7 million Australian women, yet many cases remain under-recognised and under-treated. Some women may also have underlying bleeding disorders that go undiagnosed for years.

The research will investigate the biological causes of heavy menstrual bleeding using advanced laboratory testing and aims to develop a simple screening approach to support earlier diagnosis and more personalised treatment.

Read more: https://www.centenary.org.au/news/centenary-researchers-aim-to-improve-diagnosis-of-heavy-menstrual-bleeding/

🔬New insight into liver ‘cross-talk’ could help tackle fatty liver disease 🔬Researchers from the Centenary Institute and...
13/05/2026

🔬New insight into liver ‘cross-talk’ could help tackle fatty liver disease 🔬

Researchers from the Centenary Institute and Tianjin Medical University have discovered a key communication pathway in the liver that helps control fat build-up, offering a promising new direction for tackling fatty liver disease.

The study found that when communication between liver blood vessel cells and liver cells breaks down, fat can build up in the liver, contributing to this condition.

Encouragingly, and in preclinical models, restoring this communication pathway reduces liver fat build-up, pointing to a potential new approach for future treatments.

Read more: https://www.centenary.org.au/news/new-insight-into-liver-cross-talk-could-help-tackle-fatty-liver-disease/

🩸A new discovery is changing how we understand blood clotting 🩸Centenary researchers have found that fibrinogen, a prote...
30/04/2026

🩸A new discovery is changing how we understand blood clotting 🩸

Centenary researchers have found that fibrinogen, a protein that helps clot blood, is far more complex than previously thought.

Rather than being a single, stable molecule, fibrinogen can take on different forms that may be optimised for different functions.

This insight could help improve how conditions like stroke, deep vein thrombosis and bleeding disorders are assessed and managed in the future.

🔬 It’s an important step towards more personalised care for patients.

Read more: https://www.centenary.org.au/news/blood-clotting-proteins-hidden-complexity-revealed/

There’s something special about bringing people into the lab.🧪Last week, we welcomed our community into the Centenary In...
30/04/2026

There’s something special about bringing people into the lab.🧪

Last week, we welcomed our community into the Centenary Institute to see firsthand how their perspectives help shape the work happening in our labs every day.

Because better research happens when it’s informed by the people it’s designed to help.

Keen to advise on our research? We’d love to hear from you:
👉 https://www.centenary.org.au/support-us/advise-on-our-research/

✨ Researcher spotlight: Dr Tracy Liu ✨ Inspired by family members affected by metabolic conditions, Tracy is now helpi...
24/04/2026

✨ Researcher spotlight: Dr Tracy Liu ✨

Inspired by family members affected by metabolic conditions, Tracy is now helping drive research into a disease that affects up to one in three Australians.

Tracy is a part of Australia’s seven-year Snow Program for Liver Health, focused on fighting fatty liver disease, and works across the Centenary Institute and The Heart Research Institute (HRI).

Her work targets ‘messenger’ fats called bioactive lipids, which play a key role in how the disease develops and progresses. By understanding how these lipids work inside our cells, Tracy hopes to unlock new, more personalised treatment options.

“Fatty liver disease is extremely complex and can progress to cirrhosis or liver cancer,” she says. “We need better ways to understand and treat it.”

From the lab to hiking and playing the guzheng, Tracy brings both passion and balance to her work, driving research that could make a real difference for patients.

Read more: https://www.centenary.org.au/news/researcher-spotlight-dr-tracy-liu/

❤️‍🩹 A new genetic discovery has revealed a previously hidden cause of sudden cardiac death in young people — a tragedy ...
16/04/2026

❤️‍🩹 A new genetic discovery has revealed a previously hidden cause of sudden cardiac death in young people — a tragedy that affects up to three Australians each week ❤️‍🩹

“This is an important new piece of the puzzle… bringing clarity to families who have lost someone far too soon,” said Centenary's A/Prof Richard Bagnall (pictured left with Dr Charlotte Burns, co-authors on the study).

This research was supported in part by Alexandra's Mission, created in memory of Alexandra Thoms, who died suddenly at just 23 from an undiagnosed heart condition.

The findings strengthen the call for legislative change and funding to make postmortem genetic testing a routine part of coronial investigations, giving families the best chance of answers after unexpected loss.

🔗 Read more: https://www.centenary.org.au/news/new-genetic-discovery-on-sudden-cardiac-death-in-the-young/

✨ Researcher spotlight: Associate Professor Chuck Bailey ✨For more than 25 years, Associate Professor Chuck Bailey has b...
07/04/2026

✨ Researcher spotlight: Associate Professor Chuck Bailey ✨

For more than 25 years, Associate Professor Chuck Bailey has been behind some of Centenary’s most important scientific discoveries.

Early in his career, fresh from a PhD at UNSW, Chuck uncovered the genetic causes of three rare inherited disorders — work that helped families finally understand the origins of their conditions. He later contributed to major breakthroughs in how genes are switched on and off, shaping our understanding of human biology.

Most recently, Chuck and his team published a landmark discovery in Cell Press: a completely new way that adeno‑associated viruses (AAVs) enter human cells. This seven‑year effort, supported by philanthropic organisations Tour de Cure Australia and Cure the Future as well as the National Health and Medical Research Council - NHMRC, opens the door to safer, more effective gene therapies for people living with rare diseases.

Now leading Centenary’s Centre for Rare Diseases & Gene Therapy and teaching at the University of Sydney, Chuck is helping drive the next generation of treatments for conditions that currently have no cure.

His philosophy is simple: stay curious, work hard, be brave — because every major discovery starts with a single spark of insight.

Tuberculosis (TB) is the world’s deadliest infectious disease, killing approximately 1.3 million people each year. It’s ...
24/03/2026

Tuberculosis (TB) is the world’s deadliest infectious disease, killing approximately 1.3 million people each year. It’s been around for thousands of years, and alarmingly, it’s estimated that 25% of the world’s population is infected.

This World TB Day, we reflect on the pioneering work of our researchers, led by Professor Warwick Britton over more than three decades to move in on this ancient disease. Their work has:

💉Developed a new type of nasally-administered vaccine

🛑 Created better ways of controlling the spread of the disease

⚠️ Shown how some rheumatoid arthritis treatments may make people more vulnerable to TB.

And their latest research has shown:

🦠 How experimental antibiotics could be used as next-generation treatments.

Explore more of our impact over our four decades.
www.centenary.org.au/impact



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Image by former Centenary PhD student Erica Stewart shows a mouse lung after a fluorescent form of a vaccine has been inhaled.

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