31/07/2026
I talk about this often. Ultimately, the person sitting in front of you matters. There are many reasons why similar microbiome patterns can result in very different clinical presentations. One area we're beginning to understand in more detail is bacterial strain and functional diversity. This is likely to explain at least some of what we observe clinically, including asymptomatic CST IV communities and cytolytic v.ginosis.
New research: A new paper showed that not all Gardnerella dominated microbiomes are the same. The researchers identified multiple Gardnerella community types with different genes, functions, activity and interactions with the host immune system.
It reinforces something I've taught for a long time: understanding a clinical picture has to extend beyond the microbe name.
The ecological context, functional potential, surrounding microbial community, symptoms, hormones, immune function, life stage, s3xual ecology and overall host health all contribute to clinical decision-making.
The microbiome is the footprint of an ecosystem, not the ecosystem itself. A clue for us to follow and piece together. Part of what I love about my job.
Are you thinking about your clients this way when interpreting genitourinary microbiome results?
These are the concepts we explore in Vagiversity, my six month education and mentoring program for practitioners. The next cohort begins 18 August.
If you're ready to move beyond pattern recognition and into ecological clinical reasoning, I'd love to have you join me. Link in bio.
Ref: Williams, A., Maros, A., France, M. T., Ravel, J., & Holm, J. B. (2026). Not all vaginal microbiomes are equal: functional context shapes immune landscapes. mBio, e03645-25.
ClinicalReasoning