11/08/2026
Familial Mediterranean Fever (FMF) is the most common inherited , affecting an estimated 1-2 in every 1,000 people in high-prevalence populations, including those of Mediterranean, Middle Eastern, Armenian and Jewish ancestry. FMF begins in childhood, causing recurring fevers, painful rashes and joint pain. 🔥
Dr Shouya Feng, Prof Seth Masters, clinicians at Monash Health, alongside collaborators in South Korea and the USA, have now discovered it comes down to a mutation in a single gene called CDC42, which changes the characteristics of the protein that gene produces. 🧑🏽🔬🧪
This has lead to the treatment of a family who lived with an illness that resembled FMF for over 20 years. They were treated with , a drug that blocks the specific inflammatory signal involved. Symptoms that had lasted decades came under control almost immediately.
Read more in Science Immunology, and at the link here: https://bit.ly/4z5rVDy