29/08/2026
Will VDPHL01 actually reduce oedema?
That’s one of the most important questions still facing this emerging treatment.
One of the proposed advantages of VDPHL01 is that its extended-release design may help avoid the high peak blood concentrations seen with standard oral minoxidil, which some researchers believe may contribute to side effects such as fluid retention and oedema.
The challenge?
VDPHL01 also appears to expose the body to substantially more minoxidil overall than conventional dosing.
So while peak concentrations may be lower, total drug exposure is significantly higher.
That creates an interesting scientific question:
Can you reduce oedema by smoothing out the peaks while simultaneously increasing overall exposure?
Or will oedema rates ultimately remain similar once larger numbers of patients are studied over longer periods?
At the moment, we simply don’t know.
This is one of the key reasons many clinicians are eagerly awaiting peer-reviewed publications and longer-term safety data before drawing firm conclusions about the real-world tolerability of VDPHL01.
The early efficacy results are certainly exciting.
But when it comes to side effects, the devil is often in the details.
Do you think lower peaks or lower total exposure is likely to matter more when it comes to side effects?
👇 Let me know below.
HairLossTreatment HairScience Oedema EvidenceBasedMedicine DrHopkirk FYP foryou
Medical Disclaimer: This is for educational purposes only and not an endorsement of the research ingredient. All medical treatments carry potential risks, side effects, benefits, and limitations. These risks are unique to both the treatment being considered and the individual receiving it, and are discussed in detail during consultation with one of our doctors before any treatment is commenced. Not all treatments are suitable for every patient. Results vary between individuals and depend on multiple factors including the cause of hair loss, medical history, and adherence to treatment. Any pricing or treatment information is general in nature and subject to consultation.