09/06/2026
Migraine and mental health are deeply intertwined — and understanding this connection can be life-changing.
People living with migraine are 2-3 times more likely to experience anxiety and depression. And the relationship goes both ways: anxiety and depression can increase migraine frequency, and frequent migraines can worsen mental health.
Why does this happen?
• Shared neurobiology – both migraine and mood disorders involve serotonin, dopamine, and the limbic system
• Central sensitisation – the nervous system in chronic pain states becomes hyper-reactive, amplifying both pain and emotional distress
• The burden of unpredictability – not knowing when the next attack will strike causes ongoing anxiety and avoidance behaviours
• Social isolation – missed events, cancelled plans, and reduced productivity take a toll on mental wellbeing
Breaking the cycle requires addressing both the migraine AND the mental health impact.
At Perth Migraine Centre and our associated clinics, we take a whole-person approach. We consider sleep, stress, lifestyle, psychology, and physiology — because your brain is one integrated system.
If you are struggling with both migraine and your mental wellbeing, please know: you are not alone, and help is available. We can connect you with the right multidisciplinary support.
📍 Perth Migraine Centre | Nervesync | BIIO
Photo by Paola Chaaya on Unsplash
📬 Contact:
📍 Raelene Clark | Orofacial Pain Practitioner | Comprehensive Headache & Migraine Solutions
Nervesync | Perth Migraine Centre
19/3 Wexford St, Subiaco WA 6008 | Ph: (08) 6243 0334
BIIO
224 Rokeby Rd, Subiaco WA 6008 | Ph: 1300 184 664
Medika Headache Clinic | Vyepti Infusion Clinic
4/476 Wanneroo Rd, Westminster WA 6064