26/12/2025
đClubbing â āĻāϏāϞ⧠āĻā§āύ āĻšā§?
āĻ
āύā§āĻā§ āĻāĻžāĻŦā§ clubbing āĻŽāĻžāύ⧠āĻļā§āϧ⧠āύāĻ āĻŽā§āĻāĻž āĻšā§ā§ āϝāĻžāĻā§āĻžāĨ¤
āύāĻž āĻāϰ āĻĒā§āĻāύ⧠āĻāĻŋāύā§āϤ⧠āϏā§āύā§āĻĻāϰ āĻāĻāĻāĻž pathophysiology āĻāĻā§
Normally āĻā§ āĻšā§?
Bone marrow āĻĨā§āĻā§ megakaryocyte āĻŦā§āϰ āĻšā§ â
āĻĢā§āϏāĻĢā§āϏā§āϰ pulmonary capillary-āϤ⧠āĻāĻŋā§ā§ āĻāĻā§āϞ⧠āĻā§āĻā§ platelet āĻšā§āĨ¤
â
Lung āĻāĻāĻžāύ⧠āĻāĻāĻāĻž filter-āĻāϰ āĻŽāϤ⧠āĻāĻžāĻ āĻāϰā§āĨ¤
â āĻāĻŋāύā§āϤ⧠āϏāĻŽāϏā§āϝāĻž āĻā§āĻĨāĻžā§?
āĻāĻŋāĻā§ āϰā§āĻā§ lung āĻāĻ filter-āĻāϰ āĻāĻžāĻ āĻ āĻŋāĻāĻŽāϤ⧠āĻāϰāϤ⧠āĻĒāĻžāϰ⧠āύāĻž, āϝā§āĻŽāύāĻ
-Chronic lung disease,Lung cancer,Cyanotic congenital heart disease
,Pulmonary AV shunt
āϤāĻāύ megakaryocyte intact āĻ
āĻŦāϏā§āĻĨāĻžā§ systemic circulation-āĻ āĻāϞ⧠āϝāĻžā§
#āĻāϰāĻĒāϰ āĻā§ āĻšā§?
āĻāĻ megakaryocyte āĻā§āϞ⧠āĻāĻŋā§ā§ āĻāĻāĻā§ āϝāĻžā§â
â finger tip / nail bed-āĻ
āϏā§āĻāĻžāύ⧠āĻāĻŋā§ā§ āĻāĻā§āϞ⧠release āĻāϰ⧠āĻāĻŋāĻā§ powerful chemical:
-PDGF (Platelet-derived growth factor)
-VEGF (Vascular endothelial growth factor)
āĻāĻ growth factor āĻā§āϞ⧠āĻā§ āĻāϰā§?
-Blood vessel āĻŦāĻžā§āĻžā§ (angiogenesis)
-Fibroblast activation
-Soft tissue overgrowth āĻāϰā§
đāϤāĻāύ nail bed āĻšā§ā§ āϝāĻžā§
âī¸ soft
âī¸ spongy
âī¸ bulky
āϤāĻžāĻšāϞ⧠Result āĻā§?= CLUBBING āĻšāĻā§āĻā§
đĢ Hypoxia-āĻāϰ role āĻāĻā§?
āĻšā§āϝāĻžāĻ, chronic hypoxia â VEGF āĻŦāĻžā§āĻžā§ â clubbing worsen āĻāϰā§
â āĻāĻŋāύā§āϤ⧠hypoxia āĻāĻāĻž clubbing āĻāϰāϤ⧠āĻĒāĻžāϰā§
Dr-Tasbiha Khanam
MBBS,
PGT (Medicine)
CMU (Ultrasound)