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The skeletal system includes all of the bones and joints in the body. Each bone is a complex living organ that is made u...
20/05/2026

The skeletal system includes all of the bones and joints in the body. Each bone is a complex living organ that is made up of many cells, protein fibers, and minerals. The skeleton acts as a scaffold by providing support and protection for the soft tissues that make up the rest of the body. The skeletal system also provides attachment points for muscles to allow movements at the joints. New blood cells are produced by the red bone marrow inside of our bones. Bones act as the body's warehouse for calcium, iron, and energy in the form of fat. Finally, the skeleton grows throughout childhood and provides a framework for the rest of the body to grow along with it.

Skeletal System Anatomy
The skeletal system in an adult body is made up of 206 individual bones. These bones are arranged into two major divisions: the axial skeleton and the appendicular skeleton. The axial skeleton runs along the body's midline axis and is made up of 80 bones in the following regions:
- Skull
- Hyoid
- Auditory ossicles
- Ribs
- Sternum
- Vertebral column

The appendicular skeleton is made up of 126 bones in the folowing regions:
- Upper limbs
- Lower limbs
- Pelvic girdle
- Pectoral (shoulder) girdle

Skull The skull is composed of 22 bones that are fused together except for the mandible. These 21 fused bones are separate in children to allow the skull and brain to grow, but fuse to give added strength and protection as an adult. The mandible remains as a movable jaw bone and forms the only movable joint in the skull with the temporal bone.
The bones of the superior portion of the skull are known as the cranium and protect the brain from damage. The bones of the inferior and anterior portion of the skull are known as facial bones and support the eyes, nose, and mouth.

Hyoid and Auditory Ossicles
The hyoid is a small, U-shaped bone found just inferior to the mandible. The hyoid is the only bone in the body that does not form a joint with any other boneÑit is a floating bone. The hyoid's function is to help hold the trachea open and to form a bony connection for the tongue muscles.
The malleus, incus, and stapes are known collectively as the auditory ossiclesÑare the smallest bones in the body. Found in a small cavity inside of the temporal bone, they serve to transmit and amplify sound from the eardrum to the inner ear.

Vertebrae
Twenty-six vertebrae form the vertebral column of the human body. They are named by region:
- Cervical (neck) - 7 vertebrae
- Thoracic (chest) - 12 vertebrae
- Lumbar (lower back) - 5 vertebrae
- Sacrum - 1 vertebra
- Coccyx (tailbone) - 1 vertebra
With the exception of the singular sacrum and coccyx, each vertebra is named for the first letter of its region and its position along the superior-inferior axis. For example, the most superior thoracic vertebra is called T1 and the most inferior is called T12.

Ribs and Sternum
The sternum, or breastbone, is a thin, knife-shaped bone located along the midline of the anterior side of the thoracic region of the skeleton. The sternum connects to the ribs by thin bands of cartilage called the costal cartilage.
There are 12 pairs of ribs that together with the sternum form the ribcage of the thoracic region. The first seven ribs are known as "true ribs'' because they connect the thoracic vertebrae directly to the sternum through their own band of costal cartilage. Ribs 8, 9, and 10 all connect to the sternum through cartilage that is connected to the cartilage of the seventh rib, so we consider these to be ''false ribs.'' Ribs 11 and 12 are also false ribs, but are also considered to be ''floating ribs'' because they do not have any cartilage attachment to the sternum at all.

Pectoral Girdle and Upper Limb
The pectoral girdle connects the upper limb (arm) bones to the axial skeleton and consists of the left and right clavicles and left and right scapulae.
The humerus is the bone of the upper arm. It forms the ball and socket joint of the shoulder with the scapula and forms the elbow joint with the lower arm bones. The radius and ulna are the two bones of the forearm. The ulna is on the medial side of the forearm and forms a hinge joint with the humerus at the elbow. The radius allows the forearm and hand to turn over at the wrist joint.
The lower arm bones form the wrist joint with the carpals, a group of eight small bones that give added flexibility to the wrist. The carpals are connected to the five metacarpals that form the bones of the hand and connect to each of the fingers. Each finger has three bones known as phalanges, except for the thumb, which only has two phalanges.

Pelvic Girdle and Lower Limb
Formed by the left and right hip bones, the pelvic girdle connects the lower limb (leg) bones to the axial skeleton.
The femur is the largest bone in the body and the only bone of the thigh (femoral) region. The femur forms the ball and socket hip joint with the hip bone and forms the knee joint with the tibia and patella. Commonly called the kneecap, the patella is special because it is one of the few bones that are not present at birth. The patella forms in early childhood to support the knee for walking and crawling.
The tibia and fibula are the bones of the lower leg. The tibia is much larger than the fibula and bears almost all of the body's weight. The fibula is mainly a muscle attachment point and is used to help maintain balance. The tibia and fibula form the ankle joint with the talus, one of the seven tarsal bones in the foot.
The tarsals are a group of seven small bones that form the posterior end of the foot and heel. The tarsals form joints with the five long metatarsals of the foot. Then each of the metatarsals forms a joint with one of the set of phalanges in the toes. Each toe has three phalanges, except for the big toe, which only has two phalanges.

Microscopic Structure of Bones
The skeleton makes up about 30-40% of an adult's body mass. The skeleton's mass is made up of nonliving bone matrix and many tiny bone cells. Roughly half of the bone matrix's mass is water, while the other half is collagen protein and solid crystals of calcium carbonate and calcium phosphate.
Living bone cells are found on the edges of bones and in small cavities inside of the bone matrix. Although these cells make up very little of the total bone mass, they have several very important roles in the functions of the skeletal system. The bone cells allow bones to:

- Grow and develop
- Be repaired following an injury or daily wear
- Be broken down to release their stored minerals

Types of Bones
All of the bones of the body can be broken down into five types: long, short, flat, irregular, and sesamoid.
Long. Long bones are longer than they are wide and are the major bones of the limbs. Long bones grow more than the other classes of bone throughout childhood and so are responsible for the bulk of our height as adults. A hollow medullary cavity is found in the center of long bones and serves as a storage area for bone marrow. Examples of long bones include the femur, tibia, fibula, metatarsals, and phalanges.
Short. Short bones are about as long as they are wide and are often cubed or round in shape. The carpal bones of the wrist and the tarsal bones of the foot are examples of short bones.
Flat. Flat bones vary greatly in size and shape, but have the common feature of being very thin in one direction. Because they are thin, flat bones do not have a medullary cavity like the long bones. The frontal, parietal, and occipital bones of the craniumÑalong with the ribs and hip bonesÑare all examples of flat bones.
Irregular. Irregular bones have a shape that does not fit the pattern of the long, short, or flat bones. The vertebrae, sacrum, and coccyx of the spineÑas well as the sphenoid, ethmoid, and zygomatic bones of the skullÑare all irregular bones.
Sesamoid. The sesamoid bones are formed after birth inside of tendons that run across joints. Sesamoid bones grow to protect the tendon from stresses and strains at the joint and can help to give a mechanical advantage to muscles pulling on the tendon. The patella and the pisiform bone of the carpals are the only sesamoid bones that are counted as part of the 206 bones of the body. Other sesamoid bones can form in the joints of the hands and feet, but are not present in all people.

Parts of Bones
The long bones of the body contain many distinct regions due to the way in which they develop. At birth, each long bone is made of three individual bones separated by hyaline cartilage. Each end bone is called an epiphysis (epi = on; physis = to grow) while the middle bone is called a diaphysis (dia = passing through). The epiphyses and diaphysis grow towards one another and eventually fuse into one bone. The region of growth and eventual fusion in between the epiphysis and diaphysis is called the metaphysis (meta = after). Once the long bone parts have fused together, the only hyaline cartilage left in the bone is found as articular cartilage on the ends of the bone that form joints with other bones. The articular cartilage acts as a shock absorber and gliding surface between the bones to facilitate movement at the joint.
Looking at a bone in cross section, there are several distinct layered regions that make up a bone. The outside of a bone is covered in a thin layer of dense irregular connective tissue called the periosteum. The periosteum contains many strong collagen fibers that are used to firmly anchor tendons and muscles to the bone for movement. Stem cells and osteoblast cells in the periosteum are involved in the growth and repair of the outside of the bone due to stress and injury. Blood vessels present in the periosteum provide energy to the cells on the surface of the bone and pe*****te into the bone itself to nourish the cells inside of the bone. The periosteum also contains nervous tissue and many nerve endings to give bone its sensitivity to pain when injured.
Deep to the periosteum is the compact bone that makes up the hard, mineralized portion of the bone. Compact bone is made of a matrix of hard mineral salts reinforced with tough collagen fibers. Many tiny cells called osteocytes live in small spaces in the matrix and help to maintain the strength and integrity of the compact bone.
Deep to the compact bone layer is a region of spongy bone where the bone tissue grows in thin columns called trabeculae with spaces for red bone marrow in between. The trabeculae grow in a specific pattern to resist outside stresses with the least amount of mass possible, keeping bones light but strong. Long bones have a spongy bone on their ends but have a hollow medullary cavity in the middle of the diaphysis. The medullary cavity contains red bone marrow during childhood, eventually turning into yellow bone marrow after puberty.

Articulations
An articulation, or joint, is a point of contact between bones, between a bone and cartilage, or between a bone and a tooth. Synovial joints are the most common type of articulation and feature a small gap between the bones. This gap allows a free range of motion and space for synovial fluid to lubricate the joint. Fibrous joints exist where bones are very tightly joined and offer little to no movement between the bones. Fibrous joints also hold teeth in their bony sockets. Finally, cartilaginous joints are formed where bone meets cartilage or where there is a layer of cartilage between two bones. These joints provide a small amount of flexibility in the joint due to the gel-like consistency of cartilage

19/05/2026

Cardio Vascular System

The cardiovascular system consists of the heart, blood vessels, and the approximately 5 liters of blood that the blood vessels transport. Responsible for transporting oxygen, nutrients, hormones, and cellular waste products throughout the body, the cardiovascular system is powered by the body's hardest-working organ the heart, which is only about the size of a closed fist. Even at rest, the average heart easily pumps over 5 liters of blood throughout the body every minute.

The Heart
The heart is a muscular pumping organ located medial to the lungs along the body's midline in the thoracic region. The bottom tip of the heart, known as its apex, is turned to the left, so that about 2/3 of the heart is located on the body's left side with the other 1/3 on right. The top of the heart, known as the heart's base, connects to the great blood vessels of the body: the aorta, vena cava, pulmonary trunk, and pulmonary veins.

Blood Vessels
Blood vessels are the body's highways that allow blood to flow quickly and efficiently from the heart to every region of the body and back again. The size of blood vessels corresponds with the amount of blood that passes through the vessel. All blood vessels contain a hollow area called the lumen through which blood is able to flow. Around the lumen is the wall of the vessel, which may be thin in the case of capillaries or very thick in the case of arteries.

All blood vessels are lined with a thin layer of simple squamous epithelium known as the endothelium that keeps blood cells inside of the blood vessels and prevents clots from forming. The endothelium lines the entire circulatory system, all the way to the interior of the heart, where it is called the endocardium.
There are three major types of blood vessels: arteries, capillaries and veins. Blood vessels are often named after either the region of the body through which they carry blood or for nearby structures. For example, the brachiocephalic artery carries blood into the brachial (arm) and cephalic (head) regions. One of its branches, the subclavian artery, runs under the clavicle; hence the name subclavian. The subclavian artery runs into the axillary region where it becomes known as the axillary artery.

Blood
The average human body contains about 4 to 5 liters of blood. As a liquid connective tissue, it transports many substances through the body and helps to maintain homeostasis of nutrients, wastes, and gases. Blood is made up of red blood cells, white blood cells, platelets, and liquid plasma.

Functions of the Cardiovascular System
The cardiovascular system has three major functions: transportation of materials, protection from pathogens, and regulation of the body's homeostasis.
Transportation:
The cardiovascular system transports blood to almost all of the body's tissues. The blood delivers essential nutrients and oxygen and removes wastes and carbon dioxide to be processed or removed from the body. Hormones are transported throughout the body via the blood's liquid plasma.
Protection:
The cardiovascular system protects the body through its white blood cells. White blood cells clean up cellular debris and fight pathogens that have entered the body. Platelets and red blood cells form scabs to seal wounds and prevent pathogens from entering the body and liquids from leaking out. Blood also carries antibodies that provide specific immunity to pathogens that the body has previously been exposed to or has been vaccinated against.
Regulation:
The cardiovascular system is instrumental in the body's ability to maintain homeostatic control of several internal conditions. Blood vessels help maintain a stable body temperature by controlling the blood flow to the surface of the skin. Blood vessels near the skin's surface open during times of overheating to allow hot blood to dump its heat into the body's surroundings. In the case of hypothermia, these blood vessels constrict to keep blood flowing only to vital organs in the body's core. Blood also helps balance the body's pH due to the presence of bicarbonate ions, which act as a buffer solution. Finally, the albumins in blood plasma help to balance the osmotic concentration of the body's cells by maintaining an isotonic environment.

The Circulatory Pump
The heart is a four-chambered ''double pump'', where each side (left and right) operates as a separate pump. The left and right sides of the heart are separated by a muscular wall of tissue known as the septum of the heart. The right side of the heart receives deoxygenated blood from the systemic veins and pumps it to the lungs for oxygenation. The left side of the heart receives oxygenated blood from the lungs and pumps it through the systemic arteries to the tissues of the body. Each heartbeat results in the simultaneous pumping of both sides of the heart, making the heart a very efficient pump.

Regulation of Blood Pressure
Several functions of the cardiovascular system can control blood pressure. Certain hormones along with autonomic nerve signals from the brain affect the rate and strength of heart contractions. Greater contractile force and heart rate lead to an increase in blood pressure. Blood vessels can also affect blood pressure. Vasoconstriction decreases the diameter of an artery by contracting the smooth muscle in the arterial wall. The sympathetic (fight or flight) division of the autonomic nervous system causes vasoconstriction, which leads to increases in blood pressure and decreases in blood flow in the constricted region. Vasodilation is the expansion of an artery as the smooth muscle in the arterial wall relaxes after the fight-or-flight response wears off or under the effect of certain hormones or chemicals in the blood. The volume of blood in the body also affects blood pressure. A higher volume of blood in the body raises blood pressure by increasing the amount of blood pumped by each heartbeat. Thicker, more viscous blood from clotting disorders can also raise blood pressure.

Hemostasis
Hemostasis, or the clotting of blood and formation of scabs, is managed by the platelets of the blood. Platelets normally remain inactive in the blood until they reach damaged tissue or leak out of the blood vessels through a wound. Once active, platelets change into a spiny ball shape and become very sticky in order to latch on to damaged tissues. Platelets next release chemical clotting factors and begin to produce the protein fibrin to act as structure for the blood clot. Platelets also begin sticking together to form a platelet plug. The platelet plug will serve as a temporary seal to keep blood in the vessel and foreign material out of the vessel until the cells of the blood vessel can repair the damage to the vessel wall.

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