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Informações para nos contatar, mapa e direções, formulário para nos contatar, horário de funcionamento, serviços, classificações, fotos, vídeos e anúncios de Enzitox, Laboratório médico, UFSM, Prédio 18, sala 2208, Santa Maria.

18/11/2025

Quercetin and Tranylcypromine Improve Memory, Behavioral
Performance, and Cholinergic Function in Male Rats Subjected to Chronic Restraint Stress. 🐁🧠

DOI: 10.3390/brainsci15070709

08/08/2025

Confira os trabalhos apresentados no V Simpósio de Farmacologia 📚💚✨

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12/06/2025

VOCÊ SABIA? Amor e ATP têm mais em comum do que parece!

Enquanto você se apaixona, seu cérebro aciona sistemas complexos que envolvem dopamina, oxitocina... e até *ATP* – sim, a mesma molécula que dá energia às suas células!

Esse é o sistema purinérgico, um verdadeiro maestro bioquímico que regula:
* Emoções
* Estresse
* Sono
* Até o prazer de estar com quem você ama

A adenosina, derivada do ATP, atua reduzindo a ansiedade e favorecendo vínculos emocionais.
Em outras palavras: talvez você só precise de um pouco mais de... purinas no coração. 💞

📚 Ciência também é sobre sentir.

09/12/2024

Registros do enzitox na I Mostra Científica do .

29/11/2024

39° Jornada Acadêmica Integrada (JAI - UFSM)

30/07/2024

Conheça um pouco mais sobre a relação entre a asma e o sistema purinérgico!!! 💜💚

10/07/2024

Vem conhecer um pouco sobre a relação entre sistema purinérgico e acupuntura! 🤍❤

30/04/2024

Relembrando de um dos nossos maravilhosos artigos publicados anteriormente! 💚

Sobre: Perfis farmacocinéticos, citotoxicidade e metabolismo redox da curcumina livre e nanoencapsulada

Abstract:
"To analyze the biodistribution, pharmacokinetics, and toxicity of curcumin, we made in silico predictions and performed in vitro tests to demonstrate the differences in the behavior of two cells types (peripheral blood mononuclear cells, PBMCs, and fibroblasts, HFF-1 cell line) treated with curcumin nanocapsule formulations and curcumin solution with respect to cytotoxic effects and redox metabolism. We generated in silico, ADME/Tox profile predictions of curcumin using computational tools. We produced and characterized Eudragit® L-100 and PCL nanocapsules containing curcumin using interfacial deposition of preformed polymer, evaluation of hemolytic potential in erythrocytes, cytotoxic capacity (MTT and dsDNA PicoGreen® assay), and influence on redox metabolism (nitric oxide and DCF production) of PBMCs and HFF-1 treated with curcumin nanoformulations and solution response curves. Computational results showed low biodistribution, no permeation at of the blood-brain barrier (BBB), discreet gastrointestinal absorption, a potential inhibitor of cytochrome P450 isoforms (CYP2C9 and CYP3A4), toxicity class IV, and immunomodulatory action. In vitro tests showed that cell type influenced curcumin behavior. For cytotoxicity, PBMCs showed a concentration-dependent standard, while HFF-1 cells showed that incubation time was an important variable. Redox interactions showed that nanocapsules induced NO production, and all treatments reduced DCF levels. We highlight the pleiotropic biological activities of curcumin and drug release models so that the therapeutic properties of this polyphenol might be better used. Finally, we emphasize that pharmacological safety must always be evaluated in drug delivery systems and, especially, for substances with multiple interaction pathways."

LINK NOS DESTAQUES!!!

24/04/2024

Venha conhecer um pouco sobre a relação: Inflamação e o sistema purinérgico!!! 💚

16/04/2024

Vêm conhecer um pouco mais sobre a nossa linha de pesquisa!!!
CAPSAICINA!!! ❤️💚🤍

10/04/2024

Mais um de nossos artigos publicados! 💚
Título: Impacto do resveratrol no estresse oxidativo no fígado durante a infecção por Trypanosoma cruzi

Abstract:
Trypanosoma cruzi is the causative agent of Chagas disease, infecting the heart, intestines and liver tissues. There is growing evidence that oxidative stress, defined as a persistent imbalance between highly oxidative compounds and antioxidant defenses, is a marker of tissue inflammation; it is related to immune responses such as damage, as well as to strand breaks in DNA contributing to disease progression. Antioxidant agents help mitigate the damage caused by inflammation, preventing or slowing damage to cells caused by free radicals. In this sense, resveratrol (RSV) is an important polyphenol that demonstrates antioxidant effects. It reverses damage caused by several infectious diseases. The aim of the present study was to determine whether treatment with RSV would prevent or minimize oxidative damage caused by T. cruzi. The animals were divided into four groups (n = 5): A) control; B) control + RSV; C) infected and D) infected + RSV. The infected groups received 1 x 104 Y strain trypomastigotes via intraperitoneal injection; after confirmation of infection, the mice received RSV 100 mg/kg for seven days orally. On the 8th day post-infection, we collected liver tissue for analysis of oxidant/antioxidant status: superoxide dismutase (SOD), catalase (CAT), and glutathione s-transferase (GST) activities, as well as reactive oxygen species (ROS), non-protein thiols (NPSH), thiols, carbonyl protein, thiobarbituric acid reactive substance (TBARS), and finally, the nitrite/nitrate ratio (NOx) levels were determined. The administration of RSV did not exert direct effect on parasitemia. The infection produced high levels of TBARS, NOx, and ROS levels in liver tissue, suggesting cellular injury with production of free radicals in animals infected by T. cruzi. RSV positively modulated SOD and aumenting GST activities enzymes in infected animals. [...]

LINK NOS DESTAQUES!

01/04/2024

Venha conhecer um pouco mais sobre uma de nossas linhas de pesquisa!!! ❤💚

Endereço

UFSM, Prédio 18, Sala 2208
Santa Maria, RS
97105-900

Telefone

+555532208978

Site

https://linktr.ee/enzitox

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