02/11/2026
Women make up the majority of Alzheimer’s cases, and estrogen is part of the reason.
Estrogen supports blood flow to the brain and neurotransmitter production. When levels decline, the brain loses that support.
In the Cache County study, women who used hormone therapy had a 41% lower risk of Alzheimer’s disease, and those who used it for more than 10 years had a 59% lower risk.
For clinicians, this is part of the bigger picture of hormone care. The conversation isn’t only about hot flashes. It’s about protecting memory, independence and quality of life for decades to come.
Download The 2026 Clinician’s Guide to Hormone Replacement here: https://go.bhrttrainingacademy.com/clinician-guide-2025
Source: Zandi et al., JAMA, 2002