10/16/2026
Can GLP-1 medications affect mental health?
Medications such as Ozempic are increasingly used for weight management, but their potential psychological effects deserve attention. A published case report found worsening depression, anxiety, and irritability following semaglutide treatment, with symptoms improving after discontinuation. Although this does not establish causation, it highlights the importance of monitoring emotional well-being alongside physical health.
Reference: Manoharan, S. V. R. R., & Madan, R. (2024). GLP-1 agonists can affect mood: A case of worsened depression on Ozempic (semaglutide). Innovations in Clinical Neuroscience, 21(4–6), 25–26.
Glucagon-like peptide-1 (GLP-1) receptor agonists have garnered significant attention in diabetes management, and they act by mimicking the effects of GLP-1, a hormone that regulates insulin secretion and appetite. While these medications have ...
