08/18/2026
A 2026 article raises significant concerns regarding UE botox injections in pediatric unilateral CP.
"Long-term functional decline following upper limb botulinum toxin injections in children with unilateral cerebral palsy: A preliminary
retrospective 5-year follow-up case-control study".
This study followed 11 children with unilateral CP over 5 years. 5 children received a single UE Botox in conjunction with PT and 6 who received only PT.
Clinical takeaways:
*All 5 children had one Botox injection but showed deterioration in UE function.
*All 6 children who received PT showed preserved or improved UE function.
*The paper includes excellent discussions of both possible mechanisms and clinical implications.
*Children with MACS (=Manual Ability Classification System) level 1 may be particularly at risk of long-term functional deterioration.
What I'm thinking about:
*Despite the small sample size, the consistency of the outcomes merits serious consideration. These results warrant serious ongoing evaluation of the risk-benefit profile of botox injections in the paediatric CP population.
Article link: https://pubmed.ncbi.nlm.nih.gov/42602096/
Link to MACS outcome measure: https://canchild.ca/shop/macs/