13/08/2026
Peptide Series
Counter A.G.E.: When Sugar Ages Your Skin
So far we’ve looked at peptides that signal the skin to support collagen production, and peptides that help soften the appearance of expression lines, but peptides can have another interesting role: helping protect the proteins we already have.
This brings us to Circadia Counter A.G.E.
The ‘A.G.E.’ refers to Advanced Glycation End Products which are compounds that form through a process called glycation.
Glycation happens when sugars react with proteins within our tissues. In the skin, this can affect important structural proteins including collagen and elastin, causing them to become stiffer and less flexible. Over time, glycation contributes to loss of elasticity, firmness and that healthy ‘bounce’ we associate with younger skin.
Counter A.G.E. contains L-carnosine, a small peptide made from two amino acids, which is used specifically for its anti-glycation activity.
It also contains decarboxy carnosine, another carnosine derivative, alongside Tripeptide-9 Citrulline (dGlyage®), which Circadia describes as helping reduce DNA damage associated with glycation reactions and helping reduce the formation of metal-mediated A.G.E.s.
But, as always with Circadia, it isn’t relying on one ingredient.
The formula combines its peptides with Osmanthus fragrans flower extract, antioxidants and a complex containing bamboo, pea extract and glucosamine, designed to support collagen, elastin and hyaluronic acid synthesis.
So Counter A.G.E. demonstrates another reason why saying “this product contains peptides” really doesn’t tell us enough.
Some peptides send signals, some influence muscle contraction & some, like the carnosine peptides in Counter A.G.E., are used to help protect our existing proteins from damaging processes such as glycation.
Different peptides, different jobs & that’s exactly why I’m spending so much time talking about them!
This serum is the perfect partner to our Glyco-Guard moisturiser, come back tomorrow to learn all about it!