28/06/2025
SHOULD I BE HAVING BLOOD TESTS TO CHECK MY OESTRADIOL LEVEL WHEN USING HRT? đ§
This is a question which comes up frequently!
The short answer is no. Routine testing and monitoring is not usually requiredâŚ
âď¸BUTâď¸There are a few things to know as itâs often not as straightforward as that!
đ Take perimenopause for instanceâŚ
đ During perimenopause, hormone levels can fluctuate markedly day to day and even hour to hour, and so blood tests can be of less value during this phase, whether using HRT or not. Worth noting too that symptoms can sometimes be more common in perimenopause - even when using HRT - due to these fluctuations.
đ Are symptoms more important then?
đ When taking HRT at any stage of perimenopause / menopause, itâs important to use your symptoms as a guide to how well itâs working.
đ Hormonal âblipsâ are pretty common though (e.g.,stress, illness, changing production of own hormones etc.,) and can happen from time to time. If this happens, you may find you have a return of symptoms which resolves within a few days / weeks, so itâs worth keeping an eye on this first before heading to your doctor.
đ If youâre symptomatic on HRT and this isnât improving, it can be a sign that something needs to be adjusted or that there are potentially other causes (such as low thyroid, for example)
đ Do I need to âachieveâ a particular oestradiol level?
đ There are many information sources which provide a âtargetâ level of oestradiol for symptom control - we even have some guidance on the group! However, as above, be led by your symptoms first and foremostâŚthereâs no need to try to âachieveâ a certain level if you feel well đ
đ BUTâŚwhat about things like bone health?
đ A decades-old study cited a target level of oestradiol (around 250pmol/l) for best protection of bone health, however bone is super sensitive to oestradiol and some studies have shown that even an ultra low dose of HRT may provide some protection.
đ What if absorption is an issue?
đ A 2024 study showed that around 20% of women may be poor absorbers of transdermal oestrogen and we see this often in the group too! In this case, assessing oestradiol levels can be useful when a woman has reached the maximum licensed dose (those equivalent to 100mcg) and is still symptomatic, with other causes ruled out, to help guide next steps.
đ What can affect oestradiol levels?
đ There are actually several factors which can affect the level of oestradiol in your blood. For example, changes in your own production of hormone, absorption, the timing of bloods taken, BMI, exercise, alcohol, and the uptake and use of oestradiol by your tissues.
đ In shortâŚ
If feeling well
âĄď¸ No action needed.
If symptomatic and under maximum dose
âĄď¸ Monitor symptoms at first, and if ongoing longer than a few weeks, speak to your doctor about an HRT review / change in dose and / or having bloods for general health check.
If symptomatic and at maximum dose
âĄď¸ Monitor symptoms at first, and if ongoing longer than a few weeks, speak to your doctor about having oestradiol checked, and a blood panel for general health, or about changing the type of HRT you use
Nicola đđđ