21/10/2021
❌High body fat & musculoskeletal pain❌
🗣Why do we ask patients with joint pain( low back pain, knee pain especially) to lose weight?
➡️ There's a strong relationship between musculoskeletal pain & obesity 1️⃣
➡️ furthermore, it has been found that there is a positive association between increased body fat and single-site joint pain in the low back, knee & foot, it could be explained that excessive adiposity may blunt the leptin signalling pathway, which in turn compromise its ability to repair joint cartilage(in knee joint) by a down-regulation in receptor expression 2️⃣, and may contribute to osteoarthritis 3️⃣
Read the full article:
https://rdcu.be/czWyH
1️⃣ Cameron AJ, Magliano DJ, Dunstan DW, Zimmet PZ, Hesketh K, Peeters A, et al. A bi-directional relationship between obesity and health-related quality of life: evidence from the longitudinal AusDiab study. Int J Obes. 2012;36:295–303
2️⃣ Liu ZJ, Bian J, Liu J, Endoh A. Obesity reduced the gene expressions of leptin receptors in hypothalamus and liver. Horm Metab Res. 2007;39:489–94.
3️⃣ Livsh*ts G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford study. Arthritis Rheum. 2009;60:2037–45