KYZN

KYZN KYZN - Specialist Medical & Surgical Healthcare & Wellness

28/08/2026

Dangerous or safe? Quick verdicts on the longevity treatments everyone is asking about, exactly as I gave them on camera.

Peptide stacks from the gym: definitely dangerous, I do not trust them. NAD IV drips: potentially dangerous. Young plasma exchange: no good evidence, potentially dangerous. Whole body cryotherapy: evidence not great, usually safe, can help some people in certain conditions. Stem cell tourism abroad: can be really dangerous, even a few deaths reported. Hyperbaric oxygen: reasonably good evidence, one I do trust. Off-label rapamycin: potentially dangerous, helps in limited circumstances, not my go-to.

Notice the pattern. The boldest promises carry the thinnest evidence.

Educational content, not medical advice.

26/08/2026

The immortality guy just got sick. And no, this is not an attack on Bryan Johnson.

But chasing that level of optimisation carries its own risks. Two hundred pills every morning. Endless testing. Your health as a public performance. That is a stress generator, and stress is implicated in autoimmune conditions.

For perspective: autoimmune gastritis is not a game changing condition, whatever the headlines say, and autoimmune disease is not necessarily something you earn by a mistake.

He can spend two million dollars a year on his health. Most people cannot, and the leverage sits elsewhere anyway: stress reduction, eating better, moving regularly, and proper down days where you are not thinking about your health at all.

Obsession has a cost too.

Educational content, not medical advice.

24/08/2026

Are NAD drips the next big thing? Simple answer, no. They have been around for a long time. What is new is the hype.

A few honest points from the clinic. For most people, drips are not the solution. NAD exists in more bioavailable forms, injections and sublingual among them, and there are stable liposomal products, though many liposomes are unstable, so be careful.

We tested ten NAD products from Amazon. Eight had no viability. A label can promise a two-year shelf life while the active molecule is long gone.

What matters is how you take it, when, in what form, and how you monitor the effect. Measured, not marketed.

Educational content, not medical advice.

21/08/2026

Did you know the white coat was abandoned in the UK probably over twenty years ago? In Dubai and the US it is still widely used.

The UK decision followed evidence. Studies swabbed white coats and found all sorts of bacteria, carried around the ward, from patient to patient and bed to bed.

Why does it survive elsewhere? Some feel it looks cool, more doctory. And patients see a white coat and assume cleanliness. The perception is hygiene. The reality, on the swabs, was different.

It is a good reminder that in medicine, evidence outranks appearance, even when the appearance is the most trusted symbol we have.

Follow the swabs, not the costume.

19/08/2026

Your GP can now be paid to prescribe Mounjaro. That sentence deserves a careful look rather than a hot take.

The background is straightforward. There are simply not enough people on it in the UK, and the government has introduced a financial incentive: put a minimum number of patients who meet the eligibility criteria, BMI, obesity, other risk factors, onto the drug, and the practice is paid.

Why Mounjaro specifically? I honestly do not know why they picked it. What I can say is that it is a validated drug, and its evidence goes beyond weight loss: there are diabetic benefits, heart protection and more. This is not a cosmetic shortcut being pushed onto the public. It is a legitimate medicine finding its way into policy.

But here is the part I care about as a clinician, and the part an incentive scheme does not measure. The important thing is that people go into proper programmes, doing weight loss in a responsible way. Two reasons.

First, sustainability. Done properly, when someone stops the injections, they are far more likely to keep the weight off. Done as a jab alone, the weight tends to have other plans.

Second, muscle. On these drugs you are not only losing fat, you are also losing muscle. That is why a responsible programme changes the diet, increases the protein content, and adds strength training alongside the medication.

The drug can open a window. What gets built inside that window, diet, protein, strength, is the long-term strategy that may actually work for you.

Prescriptions are policy. Programmes are what change lives.

17/08/2026

Are biological age tests worth it? Only under one condition.

Biological age is just a number, and it changes from system to system. Your heart's biological age may differ from your liver, your kidneys, your brain. What most tests measure is DNA age, an indirect measure of the rest. Its real value is the trend.

Used that way, the test earns its place. Set a baseline, make a change, exercise or intermittent fasting, then watch the direction of travel. Rising over time is probably not good news. Dropping may well be a good thing.

If the number will change what you do, measure it. If it will only make you feel low while you change nothing, what is the point?

Measure to steer, not to worry.

13/08/2026

The question I am asked most about PRP is why the same preparation keeps appearing in areas that seem unrelated. Skin in one clinic, a knee in another.

It helps to start with what it actually is.

We take a small amount of your own blood and place it into a specialised tube, then into a centrifuge. Spun at speed, the components separate by weight. The heaviest settle at the bottom. Water sits at the top. We take the fraction rich in platelets and introduce it to the area that is compromised.

That is the whole preparation.

Why platelets matter becomes clearer if you think about what happens when you cut yourself. Bleeding is not simply loss. It is the beginning of a tissue response. Platelets bind to one another, recognise that an injury has occurred, and release growth factors that recruit the healing process.

So the logic is straightforward. Concentrate the cells that signal repair, and place them where repair is needed. In skin the intention is rejuvenation. In a joint it is more often a reduction in inflammation and in pain.

What I would want any patient to understand is the limit of the claim. PRP is not a super serum. It is not adding a capability your body does not have. At its best it is amplifying a signal your body already knows how to send.

That distinction matters, because it sets a realistic expectation of what a good outcome looks like. Returning toward normal is a reasonable aim. Becoming better than you have ever been is not what the biology describes.

Evidence quality varies considerably by indication, and anyone considering it should discuss their own circumstances with a clinician.

02/08/2026

There is no approved stem cell therapy for knee arthritis, or for any other musculoskeletal condition. I say that as someone who works in this field.

It is important to be precise about what that does and does not mean. It does not mean the treatment does not work. There are good studies supporting the view that these injections can help people, and I have seen them help. What it means is that the evidence has not yet reached the threshold required for formal approval, and that anyone speaking with certainty in either direction is overstating their position.

The video gives you the questions to ask. What I would add is why they are the right ones.

Ask what the evidence of effect is for your specific condition, not for regenerative medicine generally. Ask what that clinic's own results and outcome data look like, because published literature and a particular practice's outcomes are not the same thing. Ask what the alternatives are, both instead of the injection and after it. And ask what happens if it does not work, because it will not work for everybody and that conversation is much easier to have before you have paid.

A clinic that welcomes those questions is one you can work with. A clinic that becomes uncomfortable has told you something useful.

And if anyone offers you a 100% result, that is your answer.

This is general information rather than individual medical advice. Discuss your own situation with your clinician.

31/07/2026

For some people with end-stage arthritis, a total knee replacement may genuinely be the only reasonable option. I want to be clear about that before anything else.

But some people want alternatives. They want to delay surgery, or they have been told they are not medically fit enough to have it. So what options do they actually have?

There is a study worth knowing about here. Professor Hernigou, a well-known French orthopaedic surgeon, published a randomised controlled trial with an unusually elegant design. He took patients who had similar arthritis in both knees. In one knee he performed a traditional knee replacement. The other knee also needed replacing, but instead he injected bone marrow stem cells into the bone and into the joint.

Then he followed those patients for 15 to 20 years, watching one thing: how many came back to have the second knee replaced.

Less than half of them did. Bear in mind these were patients already at a stage where most surgeons would have offered a replacement on that second knee.

So when people say stem cells are a short-term fix, or that they do not manage the arthritis itself, the honest reading is more nuanced. The arthritis may still be there radiologically. But their symptoms, their inflammation and their ability to manage the joint changed enough that more than half never returned for surgery.

And we have known this for more than ten years. This is not new information, which raises a fair question about why it is not more widely available or discussed.

None of this is medical advice for any individual, and it will not be right for everyone. But if you are facing that decision, it is a conversation worth having with your surgeon.

29/07/2026

Cortisol face is not real, at least not in the way the internet is currently using it.

The trend goes like this: someone posts a photo, or sends their Instagram pictures to an account online, and is told that because their face looks puffy, their cortisol must be elevated, and here is the thing that will fix it. That last part is worth noticing. When a diagnosis arrives attached to a product, it is usually marketing rather than medicine.

Here is the more useful picture. If a clinician genuinely suspects your cortisol is too high, they do not look at a photograph. They test blood biomarkers and look for real conditions such as Cushing's or specific hormonal imbalances. That is a proper diagnostic pathway, and it exists precisely because you cannot see endocrine function from the outside.

And most facial puffiness has far more ordinary explanations. Most people are a little puffy in the morning simply because of how you have been lying, lymphatic drainage, salt levels, heat, alcohol, poor sleep. In the aesthetic space, previous injections or surgery can also create a little fullness, often under the eyes or across the cheeks. None of that is a hormonal emergency. It is a face, in the morning, behaving like a face.

I am not dismissing the underlying concern, because chronic stress is genuinely worth taking seriously. I am objecting to the diagnostic method, which is a photograph interpreted by someone with something to sell.

If you are worried about your cortisol, that is a conversation with a clinician and a blood test, not a mirror.

What health trend would you most like me to look at next? Ask below.

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