22/06/2026
Observational and retrospective studies have great value. This study on postherpetic neuralgia (PHN) (pain following herpes zoster) found that having diabetes mellitus was predictive of worse treatment outcome with acupuncture.
Why is that useful to know?
✅ For practitioners: prospective patients with diabetes can be given a more realistic prognosis. The results may also be true for diabetic patients presenting with other types of neuralgia (side note: there is some evidence supporting the use of acupuncture for diabetic peripheral neuropathy regardless).
✅ For mechanistic researchers: this confirms what we already know about diabetes mellitus regarding it's deleterious physiological affects on the peripheral nervous system. However, it ALSO adds to the mounting evidence that acupuncture's key mechanism of action is signalling via the peripheral to central nervous system. If the peripheral nervous system is damaged; it appears the therapeutic effect may be muted.
Background: Postherpetic neuralgia (PHN) is a prevalent and painful complication following herpes zoster infection, impacting patient quality of life and posing...