13/06/2026
“Duchenne Muscular Dystrophy in 30 Seconds | NCLEX/NORCET
(DMD)
Quick Notes:-
Inheritance: X-linked recessive
Gene affected: Dystrophin gene
Affected gender: Mostly boys
Onset: 2–6 years
Key symptom: Progressive proximal muscle weakness
Classic sign: Gowers' sign (uses hands to "climb up" legs when standing)
Calf muscles: Pseudohypertrophy (large calves)
Lab finding: ↑ Creatine Kinase (CK)
Complications: Cardiomyopathy, respiratory failure
Management: Corticosteroids, physiotherapy, respiratory support
Mnemonic: "DUCHENNE"
D – Dystrophin deficiency
U – Uses hands to stand (Gowers' sign)
C – Calf pseudohypertrophy
H – Hereditary (X-linked recessive)
E – Early childhood onset (2–6 years)
N – No cure, progressive disease
N – Needs wheelchair in adolescence
E – Elevated CK level