27/05/2026
The aortic valve opens around three billion times in a lifetime. The disease begins when it stops opening fully.
This is what we call aortic stenosis, a narrowing of the heart's final valve, the one through which every drop of blood leaves the heart for the rest of the body. As the opening becomes smaller, blood flow forward is reduced, and the heart compensates by working considerably harder. It manages, often for years, which is exactly why the disease can stay quiet for so long.
The condition has three principal origins, and the cause is not incidental, it tells us a great deal about how the disease is likely to behave.
Congenital. Some patients are born with a valve that has two cusps instead of three. This bicuspid valve carries normal blood flow for many years, but the asymmetric mechanics wear it down sooner than a normally formed valve. Patients with bicuspid disease often present a decade or two earlier than the calcific population. The valve frequently travels with an abnormality of the aortic wall above it, which is why, in these patients, we look at the aorta as carefully as we look at the leaflets.
Calcific. A lifetime of calcium, slowly settling into the leaflets. It is the most common cause in older adults and is often described as the valve simply wearing out with age. That description is biologically incomplete. Calcific aortic stenosis is an active, regulated process, involving inflammation, lipid deposition, and the same cellular machinery the body uses to form bone, behaving within the leaflet. The valve does not passively rust. It ossifies. This understanding is why no medication has yet succeeded in slowing it.
Rheumatic. A consequence of inadequately treated streptococcal infection in childhood, a fever that has long since passed, but the valve does not forget. Largely vanished from high-income countries; very much still present across much of India. The mechanics of disease are different, the patients are younger, and the management priorities differ accordingly.
The reason this matters for the patient reading this: the cause shapes the pace of the disease and the timing of intervention. Two patients with severely narrowed valves can be very different underneath, and a careful diagnosis is more than a single number on a report.
— Dr Praveen Chandra, Padma Shri, Chairman, Interventional Cardiology, Medanta — The Medicity. Pioneer of India's first TAVI (2010). Educational content. An individual assessment must be made with a qualified cardiologist.
[bicuspid aortic valve, calcific aortic valve disease, rheumatic aortic stenosis, aortic stenosis in India, aortic stenosis causes and risk factors, severe aortic stenosis, and congenital aortic valve disease]