20/10/2026
☢️ F-PSMA tumor sink effect ☢️ F-PSMA images demonstrate diffuse sclerotic deposits spread throughout the axial and appendicular skeleton corresponding to diffuse high PSMA expression with visually diminished physiological PSMA distribution within the salivary glands, liver/spleen, and renal parenchyma relative to expected physiological PSMA expression.
🗓️ Tumor sink effect or phenomenon describes a widespread or high volume metastatic lesions fixating a large fraction of the injected PSMA, reducing the normal physiological uptake in the remainder of the body. Normal tissue that expresses PSMA shows significantly reduced uptake throughout the body, these include the salivary glands, kidneys, liver and spleen. The tumor’s visual presentation is dominant and extensive consuming the majority of the image.