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Nuclide Notes 🩻 Nuclear Medicine & Hybrid Imaging
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☢️ F-PSMA tumor sink effect ☢️ F-PSMA images demonstrate diffuse sclerotic deposits spread throughout the axial and appe...
20/10/2026

☢️ F-PSMA tumor sink effect ☢️ F-PSMA images demonstrate diffuse sclerotic deposits spread throughout the axial and appendicular skeleton corresponding to diffuse high PSMA expression with visually diminished physiological PSMA distribution within the salivary glands, liver/spleen, and renal parenchyma relative to expected physiological PSMA expression.
🗓️ Tumor sink effect or phenomenon describes a widespread or high volume metastatic lesions fixating a large fraction of the injected PSMA, reducing the normal physiological uptake in the remainder of the body. Normal tissue that expresses PSMA shows significantly reduced uptake throughout the body, these include the salivary glands, kidneys, liver and spleen. The tumor’s visual presentation is dominant and extensive consuming the majority of the image.

☢️ Calyceal diverticulum ☢️ FDG PET/CT images show right renal cyst with dense peripheral calcific precipitate showing f...
19/10/2026

☢️ Calyceal diverticulum ☢️ FDG PET/CT images show right renal cyst with dense peripheral calcific precipitate showing focal FDG uptake previously reported and concerning lesion. The cyst shows clear direct anatomical communication with the adjacent calyx and this is highly suggestive of calyceal diverticulum with physiological FDG excretion and stasis of radioactive urine within a patent calyceal diverticulum. Confirmation with multiphasic ceCT was recommended.
🗓️ Calyceal diverticulum is a benign outpouching of the renal calyces/pelvis into the surrounding renal parenchyma. The diverticulum is lined with transitional epithelium and communicates via narrow or wide neck channel with the renal collecting system. On FDG PET/CT scans it can be mistaken for a concerning renal lesion because FDG is naturally excreted in the urine and slowly fills in the diverticulum. CT urography is the gold standard to confirm a calyceal diverticulum.

☢️ Uterine leiomyosarcoma ☢️ FDG PET/CT scan shows a well defined and large hypermetabolic cystic mass within the uterus...
18/10/2026

☢️ Uterine leiomyosarcoma ☢️ FDG PET/CT scan shows a well defined and large hypermetabolic cystic mass within the uterus, showing areas of cystic degeneration and internal calcifications. Biopsy confirmed leiomyosarcoma.
🗓️ The incidence of uterine leiomyosarcoma is around 8% of all uterine cancer, they are rare aggressive malignant tumors arising from the uterine muscles or the uterine blood vessels usually in the 6th decade of life. Commonly present as vaginal bleeding with or without vague pelvic pain. Anatomically they present as a large uterine mass with zones of necrosis and hemorrhage, they also may contain calcifications. Metabolically they show high uptake, and it is suggested the higher the SUVmax the poorer the prognosis.

☢️ Cerebellar diaschisis ☢️ FDG PET/CT scan demonstrates left cerebral hemisphere hypometalosim and corresponding enceph...
17/10/2026

☢️ Cerebellar diaschisis ☢️ FDG PET/CT scan demonstrates left cerebral hemisphere hypometalosim and corresponding encephalomalacia, and diffuse decreased FDG uptake in the contralateral right cerebellar hemisphere.
🗓️ Cerebellar diaschisis refers to a decrease in cerebellar glucose metabolism that occurs as a result of a remote injury or insult to the brain (Such as strokes or traumatic brain injury). This can be seen in FDG PET scans as a reduction in the uptake in the cerebellum relative to the contralateral cerebellar hemisphere. The cerebellum is a region of the brain that is involved in motor coordination and control, and it receives input from many other regions of the brain. When there is damage or dysfunction in these other regions, it can lead to a decrease in cerebellar activity even though the cerebellum itself may not have been directly injured which is reflected in FDG PET scans as cerebellar diaschisis.

☢️ Osteochondral Lesion of the Talus ☢️ SPECT/CT images show left talus subchondral multicystic lesion with surrounding ...
14/10/2026

☢️ Osteochondral Lesion of the Talus ☢️ SPECT/CT images show left talus subchondral multicystic lesion with surrounding sclerosis and focal cortical defects, corresponding to intense perfusion and delayed tracer uptake. Additional smaller superomedial subchondral cystic lesion corresponding to increased delayed tracer uptake.
🗓 A talar osteochondral lesion involves the articular cartilage and underlying subchondral bone, most often following ankle trauma or repeated mechanical stress. A previous traumatic event is reported in roughly 70–80% of patients, and OLT may occur in up to ~6.5% of ankle sprains.
The medial talar dome is the most common location (~73%). The centromedial and posteromedial regions account for approximately 31% and 28%. Lateral lesions are less common and are more strongly associated with acute trauma.

🧬 Read With Me | Parathyroid Scan🗓 32-year-old female with history of elevated PTH and borderline elevated calcium. ☢️ F...
13/10/2026

🧬 Read With Me | Parathyroid Scan

🗓 32-year-old female with history of elevated PTH and borderline elevated calcium.

☢️ Findings: Parathyroid adenoma located at the level of thoracic inlet.

☢️ Dual phase SPECT/CT demonstrates diffuse intense perfusion in thickened right calcaneal tendon with surrounding soft ...
11/10/2026

☢️ Dual phase SPECT/CT demonstrates diffuse intense perfusion in thickened right calcaneal tendon with surrounding soft tissue fullness along its course. There is gross precalcaneal soft tissue collection of intense perfusion with obliteration of fat planes and extending along the Haglund resection line, associated subdermal thickening and fat infiltration of intense perfusion. There is intense delayed tracer uptake along the Haglund process resection line and posterior aspect of the calcaneus. Findings are consistent with intensely inflammatory right precalcaneal soft tissue collection with septic involvement of the calcaneus following Haglund’s resection surgery.

☢️ Jejunal adenocarcinoma ☢️ FDG PET/CT shows hypermetabolic proximal jejunal annular mural thickening with subsequent l...
10/10/2026

☢️ Jejunal adenocarcinoma ☢️ FDG PET/CT shows hypermetabolic proximal jejunal annular mural thickening with subsequent luminal tapering and upstream dilatation of the duodenal and gastric lumen. The regional planes are infiltrated with fat stranding and nodular thickening. There is a hypermetabolic focal area in D12 right pedicle without an underlying osseous deposit, suggestive of marrow deposit.
🗓 Small bowel adenocarcinoma is a rare malignancy (

☢️ Gluteus medius trochanteric bursitis ☢️ 79-year-old female referred for SPECT/CT bone scan as preoperative assessment...
09/10/2026

☢️ Gluteus medius trochanteric bursitis ☢️ 79-year-old female referred for SPECT/CT bone scan as preoperative assessment for a redo spinal fixation, complaining of unexplained lateralized right hip pain. SPECT/CT early phase demonstrates a paraosseous focal intense perfusion at the right lateral trochanteric facet, at the expected site of the gluteus medius tendon corresponding to a hypodensity. Delayed SPECT/CT images do not show any osseous or paraosseous abnormal uptake at the same site. Pattern suggestive of right gluteus medius trochanteric bursitis. US guided infiltration achieved complete resolution of pain.

🧠 Mini Masterclass | Myocardial Stunning📌 Myocardial stunning refers to transient post ischemic LV systolic dysfunction ...
08/10/2026

🧠 Mini Masterclass | Myocardial Stunning

📌 Myocardial stunning refers to transient post ischemic LV systolic dysfunction after stress, despite restoration of myocardial perfusion.

📌 It is typically recognized on post stress gated SPECT by a reduction in LVEF compared with rest, often accompanied by new or worsened regional wall-motion abnormalities and/or post stress LV dilatation. A post-stress EF decrease of roughly ≥5% is commonly considered significant, provided acquisition timing and technical factors are accounted for.

📌 The mechanism is that significant ischemia produces temporary contractile dysfunction that persists for minutes to hours after blood flow has been restored. Therefore, with conventional Tc 99m SPECT, perfusion images may reflect tracer uptake at peak stress while gated function is measured later; the myocardium may already have reperfused but remain mechanically depressed.

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