11/05/2026
☢️ Langerhan’s cell histocytosis ☢️ FDG PET/CT shows left mandible ramus/body expansive destructive osteolytic lesion of intense FDG uptake with soft tissue component protruding beyond the osseous margins. Additional lytic lesions of intense FDG uptake in the left parietal bone and right ilium. Biopsy revealed LCH
🗓 LCH is a tumor like disease where these cells proliferate in an uncontrollable fashion. This proliferation is accompanied by lesions or mass formation. The skeleton is the most involved organ in LCH, the cells produce prostaglandins which causes medullary bone resorption. Solitary lesions (~70%) are more common than multifocal (~17%), and the most common locations are the skull (50%), ribs/spine/pelvis/femurs (15%), humerus (7%), mandible (7%). Radiologically they have variable appearance depending on location, most commonly as lytic lesions with well defined margins and no sclerotic rims.