31/10/2025
A 45 year old lady has been presented with recurrent diarrhea, cramping abdomen and bloating. She has a 10-year history of celiac disease but has not been strictly following her gluten-free diet. Blood tests reveal elevated of IgA anti-tissue transglutaminase antibodies. What is the primary mechanism by which these antibodies contribute to the pathophysiology of her condition?
A. Antibodies bind to gluten, facilitating its uptake by enterocytes.
B. Antibodies inhibit the action of tissue transglutaminase, blocking gluten breakdown
C. Antibodies cause direct damage to the intestinal Villi
D. Antibodies form complexes with gluten that are deposited in the intestinal wall, causing an inflamatory response.
E. The Antibodies doesn't have role in pathophysiology, their presence is an incidental finding.
