07/08/2026
๐๐๐๐ญ๐๐ซ๐ข๐๐ฅ ๐๐ข๐ฏ๐๐ซ๐ฌ๐ข๐ญ๐ฒ ๐๐ฌ ๐๐๐ฒ ๐ญ๐จ ๐๐ฎ๐ข๐ฅ๐๐ข๐ง๐ ๐๐ฎ๐ฆ๐๐ง-๐๐๐ฅ๐๐ฏ๐๐ง๐ญ ๐๐ค๐ข๐ง ๐๐ข๐๐ซ๐จ๐๐ข๐จ๐ฆ๐ ๐๐จ๐๐๐ฅ๐ฌ.
The importance of the skin microbiome in human health has become increasingly evident. Despite considerable advancements, complex hostโmicrobe interactions remain largely unexplored, primarily due to a paucity of models mimicking human skin and maintaining bacterial diversity in vitro. The Bioinformatics and AI Applications Unit of IPC collaborated in a study lead by the German Federal Institute for Risk Assessment, where the role of bacterial diversity was assessed, for skinโmicrobiota co-cultivation in vitro by co-culturing reconstructed human full-thickness skin models with one of seven defined bacterial communities for seven days. The most diverse ten-strain community (BAP.10) comprised the three main skin phyla Bacillota, Actinomycetota, and Pseudomonadota. Lower diversity was obtained by the inoculation with two and one phyla combinations only. Inoculations with higher bacterial diversity were maintained at physiological bacterial counts and resulted in a higher functional similarity to human skin microbiomes, with BAP.10 showing the closest resemblance. In contrast, colonization with a single phylum led to either absence of viable bacteria or overgrowth of a single species. Overgrowth was associated with impaired skin integrity and cytotoxicity. This study demonstrates the importance of bacterial diversity and the presence of certain genera for human-relevant skin co-culture models, which can be used for future in vitro studies elucidating skinโmicrobiome interactions.
Read the full article: https://www.mdpi.com/2076-2607/14/8/1722
