21/02/2026
*HSP* is typically a self-limited disease and presents with a *classic tetrad:*
Palpable purpura *WITHOUT* thrombocytopenia or coagulopathy– Non-blanching rash, mainly on buttocks and lower limbs
*Arthralgia or arthritis* – Commonly knees and ankles– Non-erosive and transient
*Abdominal pain* – Colicky pain– May cause GI bleeding– Serious complication: intussusception
*Renal* involvement– Microscopic hematuria most common– May progress to nephritic or rarely nephrotic syndrome– Severe cases → rapidly progressive (crescentic) glomerulonephritis*Renal* involvement may appear *late* , even after rash resolves.
Renal involvement typically appears within the first 4–8 weeks, but may develop up to 6 months after onset.
*Recommended monitoring:*
Weekly for 1 month
Every 2 weeks until 3 months
Then at 6 and 12 months
*Check* :
Blood pressure
Urinalysis (hematuria, proteinuria)
Serum creatinine if abnormal findings*Renal disease determines prognosis* in HSP — not the rash.
Development of hypertension, ≥2+ proteinuria, macroscopic hematuria, or nephritic/nephrotic features requires urgent evaluation.
*Even if initial urinalysis is normal,* continue follow-up for at least 6 months (exam favorite).
*Recurrent HSP* episodes are monitored *as a first episode.*