Neuroscience Library/Bibliothèque des Neurosciences

13/09/2026

A chilling new documentary about Israel's AI-powered mass killing o...

27/08/2026

Insight in schizophrenia: From conceptualization to neuroscience

Lack of insight into illness is a prevalent and distinguishing feature of schizophrenia, which has a complex history and has been given a variety of definitions. Currently, insight is measured and treated as a multidimensional phenomenon, because it is believed to result from psychological, neuropsychological and organic factors. Thus, schizophrenia patients may display dramatic disorders including demoralization, depression and a higher risk of su***de, all of which are directly or indirectly related to a lack of insight into their illness, and make the treatment difficult. To improve the treatment of people with schizophrenia, it is thus crucial to advance research on insight into their illness. Insight is studied in a variety of ways. Studies may focus on the relationship between insight and psychopathology, may view behavioral outcomes or look discretely at the cognitive dysfunction versus anatomy level of insight. All have merit but they are dispersed across a wide body of literature and rarely are the findings integrated and synthesized in a meaningful way. The aim of this study was to synthesize findings across the large body of literature dealing with insight, to highlight its multidimensional nature, measurement, neuropsychology and social impact in schizophrenia. The extensive literature on the cognitive consequences of lack of insight and the contribution of neuroimaging techniques to elucidating neurological etiology of insight deficits, is also reviewed.

Source :

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1819.2012.02325.x

16/08/2026

19/07/2026

Between 7 October 2023 and 12 July 2026, according to the Ministry of Health, as reported by the Health Cluster, 73,231 Palestinians were killed in the Gaza Strip and another 173,686 were injured. This includes 1,084 fatalities and 3,491 injuries between the announcement of a ceasefire agreement on 10 October 2025 and 8 July 2026.

19/07/2026

Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function

Astrocytes play essential roles in the brain, and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, knowledge of how astrocytes contribute to disease pathogenesis is incomplete; accordingly, harnessing their biology toward therapeutics remains a major challenge. Here we show that the transcription factor Sox9 plays a context-specific role in maintaining astrocyte function and circuit activity in the aging hippocampus and Alzheimer’s disease (AD) models. We found that Sox9 overexpression in astrocytes in AD models clears existing amyloid beta (Aβ) plaques and preserves cognitive function. Mechanistically, Sox9 promotes the phagocytosis of Aβ plaques by astrocytes through the regulation of the phagocytic receptor MEGF10, which is sufficient to preserve cognitive function in AD models. Collectively, these studies highlight a role for astrocytic Sox9 during aging and AD while identifying Sox9−MEGF10 signaling as a prospective astrocyte-based therapeutic approach to ameliorate cognitive decline in neurodegenerative disease.

Astrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10, and this clearance of plaques is associated with the preservation of cognitive function in mouse models.

06/07/2026

Americans marked US Independence Day by burning Israeli flags, with some using the burning flags to light ci**rs and fireworks.
Former US Marine Phil Tourney said he burned the flag in remembrance of the 34 American servicemen killed in the 1967 USS Liberty incident, when a US Navy intelligence ship was attacked during the Six-Day War.
The USS Liberty incident remains disputed in some of its details. Tourney, a survivor of the attack, has publicly stated his belief that Israel was responsible for the attack.

16/05/2026

In March 2026, the Pasteur Institute of Iran sustained considerable damage from airstrikes, representing a severe threat to public health infrastructure.

In a letter, authors urgently call for international support in its restoration. Read this & more in the latest issue ▶️ http://spkl.io/6186ACm9u

15/05/2026