Center For Male Infertility, Microsurgery and Men's Health

19/06/2026

Men Can Lose Their Y Chromosome With Age, And We Finally Know The Cost : ScienceAlert

The human Y chromosome is shrinking.

05/06/2026

The role of microsurgical varicocelectomy in cases of severe oligoasthenoteratozoos***mia (OAT)—typically defined as a total motile s***m count (TMSC) less than 2 to 5 million, or a s***m concentration less than 5 million/mL—is highly strategic.
​While historical clinical paradigms often bypassed varicocele repair in severe OAT to head straight for Intracytoplasmic S***m Injection (ICSI), modern reproductive urology views the procedure as a powerful tool to either shift couples down the Assisted Reproductive Technology (ART) ladder or optimize the biological material used in ICSI. Center For Male Infertility, Microsurgery and Men's Health @ Marcy Grageda

05/06/2026

The role of microsurgical varicocelectomy in cases of severe oligoasthenoteratozoos***mia (OAT)—typically defined as a total motile s***m count (TMSC) less than 2 to 5 million, or a s***m concentration less than 5 million/mL—is highly strategic.
​While historical clinical paradigms often bypassed varicocele repair in severe OAT to head straight for Intracytoplasmic S***m Injection (ICSI), modern reproductive urology views the procedure as a powerful tool to either shift couples down the Assisted Reproductive Technology (ART) ladder or optimize the biological material used in ICSI.

25/05/2026

What are my options if there are no s***ms on Micro TESE.

​When biological s***m retrieval is truly exhausted, the conversation transitions to alternative reproductive strategies:
​Donor S***m (Therapeutic Donor Insemination / IVF): Using donor s***m allows the couple to experience pregnancy, childbirth, and a biological connection to the female partner. This can be utilized via Intrauterine Insemination (IUI) or In Vitro Fertilization (IVF).
​Embryo Donation: Couples can adopt frozen embryos remaining from another couple's successful IVF treatment.
​Adoption: Domestic, international, or foster-to-adopt pathways provide alternative routes to building a family.

15/04/2026

Microsurgical varicocelectomy is considered the gold standard treatment for male infertility caused by varicoceles, offering the highest success rates and lowest complications compared to other methods. It involves using a microscope to ligate (tie off) enlarged s***matic veins while preserving the testicular artery, lymphatics, and vas deferens to improve semen quality and testosterone levels Vivienne Ong-Siong Lusaya ryzee buban

28/03/2026

Obstructive Azoos***mia: Male infertility Microsurgery , Bilateral Vasoepididymstomy

Primary epididymal obstruction (PEO) is a relatively common cause of obstructive azoos***mia (OA), occurring when the transit of s***matozoa is blocked within the highly coiled duct of the epididymis. Because the epididymis is the site of s***m maturation and acquisition of motility, bypass or correction is required for natural conception. Vivienne Ong-Siong Lusaya

04/03/2026

What is the impact of Male infertility microsurgery on ART outcomes.

​This is where the microsurgical approach shines. The benefits aren't just about the quantity of s***m, but the quality of the genetic material.
​DNA Fragmentation and Pregnancy Rates
​Varicoceles are notorious for causing high S***m DNA Fragmentation (SDF). Even if you have enough s***m for ICSI, high fragmentation leads to poor embryo development and higher miscarriage rates.

01/03/2026

How does varicocele cause male infertility and damage s***m DNA?

​The damage occurs primarily through three mechanisms:
1.​Oxidative Stress (The Primary Culprit): The pooling of blood in dilated veins causes an overproduction of Reactive Oxygen Species (ROS)—unstable molecules that "attack" s***m. Since s***m have very little cytoplasm to store protective antioxidants, their DNA is highly vulnerable to these oxidative attacks, leading to strand breaks.
2.​Hyperthermia (Heat): The sc***um’s job is to keep the te**es about 2°C cooler than the rest of the body. Varicoceles disrupt this cooling system by bringing warm core blood into the sc***um. This heat can denature proteins and trigger "abortive apoptosis" (programmed cell death), which fragments the DNA.
3.​Hypoxia (Oxygen Deprivation): Poor blood drainage leads to a buildup of carbon dioxide and a lack of fresh, oxygenated blood. This "suffocates" the developing s***m cells, causing metabolic stress that further destabilizes the genetic material.

27/02/2026

The Alamo, originally Mission San Antonio de Valero, is a historic Spanish mission and fortress in San Antonio, Texas, famous for the 1836 Battle of the Alamo during the Texas Revolution, where a small group of Texan defenders, including Davy Crockett and Jim Bowie, fought against a much larger Mexican army. Though the defenders were defeated, their stand became a symbol of courage and a rallying cry for Texas independence, earning it the title "Shrine of Texas Liberty".