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09/04/2025

type 2 Diabetes Mellitus (T2DM)
Cause: Combination of insulin resistance and relative insulin deficiency.

Mechanism:

Insulin resistance: The body's cells (especially in muscles, fat, and liver) become less responsive to insulin.

The pancreas compensates by producing more insulin (hyperinsulinemia).

Over time, the beta cells become exhausted, leading to reduced insulin secretion.

The result is persistent hyperglycemia due to both poor glucose uptake and increased glucose production by the liver.

🔸 Key Players in Glucose Homeostasis:
Insulin (lowers blood sugar):

Increases glucose uptake by muscle and fat.

Inhibits glucose production by the liver.

Glucagon (raises blood sugar):

Stimulates glucose production in the liver.

In diabetes, the balance between these hormones is disrupted.

🔸 Summary Diagram (Simplified):
Type Insulin Mechanism Outcome
Type 1 Absent Autoimmune β-cell destruction Absolute insulin deficiency
Type 2 Present (initially high, later low) Insulin resistance + β-cell dysfunction Relative insulin deficiency