The Endocrine Club

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The Endocrine Club General endocrinology and diabetes practical points
Chairman/admin :
Abdulqawi Almansari MBBS FACP FACE

Chairman Abdulqawi Almansari MD FACP FACE
Consultant endocrinologist
Myclinic alsafa Jeddah
American board of Endocrinology Diabetes and Metabolism2000
American Board internal Medicine 1998

26/10/2026

EASD Highlight

Weight loss was also approximately 30% lower in participants with T2D than those without T2D. in patients receiving Semaglutide and Terzipatide
i.e Non diabetic lose MORE

26/10/2026

ESAD 2026 highlight
Clinicians are urged to suspect type 1 diabetes in adults < 35 years old, BMI < 25 kg/m², unintentional weight loss, diabetic ketoacidosis, or rapid progression to insulin within 3 years.

26/10/2026

Studies showed that metformin exerts a strong effect on numerous cancers , cardiovascular disease (CVD) liver diseases obesity , neurodegenerative diseases and renal diseases

Lv Z and Guo Y (2020) Front. Endocrinol. 11:191.

26/10/2026

After 5 years
The mortality of diabetic foot ulcer was 42.2 % .
73% after DFU with amputation
Malik et al. J diabetes Inv 2020

26/10/2026

A normal DHEAS makes adrenal insufficiency unlikely. DHEAS levels are low in people with primary or central adrenal insufficiency
Endocr Pract. 2011;17(2):261.

25/10/2026

EASD 2026 Highlight

Retatrutide was generally well tolerated across doses in TRIUMPH-2, with a safety profile - predominantly mild-to-moderate gastrointestinal events, low hypoglycemia risk, and no severe hypoglycemia - consistent with other incretin-based medications, supporting its use in adults with obesity and T2D

25/10/2026

ESAD 2026 highlight
Measure GAD first; if negative, add IA-2 and ZnT8.
5–10 % of adults with new-onset type 1 diabetes have no detectable antibodies, and antibody levels may fade over time.

25/10/2026

Metformin was shown to have beneficial effects on liver diseases, obesity, cardiovascular diseases, age-related diseases, and renal diseases, thus finally decreasing death risk. These actions of metformin were related to AMPK activation or mitochondrial complex I inhibition, subsequently affecting cell metabolism

Lv Z and Guo Y (2020) Front. Endocrinol. 11:191.

25/10/2026

In this study, achieving an HbA1c ≤6.5% in the first year after diagnosis was associated with a lower risk of T2D microvascular and macrovascular complications1

Diabetes Care. 2019;42(3):416-426.

24/10/2026

CGM devices sensor can be compressed during sleep, creating falsely “low” glucose measurements. Patients could check point-of-care glucose fingerstick values to evaluate whether the low glucose values are accurate
ESAP 2025

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