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Monday 08:30 - 18:00 Tuesday 08:30 - 18:00 Wednesday 08:30 - 18:00 Thursday 08:30 - 18:00 Friday 08:30 - 18:00

Academic Medicine Research Institute - AMRI

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Academic Medicine Research Institute - AMRI

The Academic Medicine Research Institute (AMRI) is a one-stop research enabler that provides admi

03/09/2026

Information on the burden of postacute sequelae following SARS-CoV-2 infection (or long COVID) amongst immunocompromised cancer patients is limited during endemicity.

Researchers from National Cancer Centre Singapore, Singapore General Hospital and Duke-NUS Medical School collaborated to evaluate the risk of long COVID in a population-based cohort of Singaporean cancer patients during Omicron predominance, as part of a multi-centre project of the national Programme for Research in Epidemic Preparedness and REsponse (PREPARE), under the Communicable Diseases Agency.

Their findings suggested that amongst COVID-19 vaccinated/boosted cancer patients, overall risk of long COVID was not significantly elevated, highlighting the continued importance of COVID-19 vaccination amongst immunocompromised cancer patients during endemicity.

Read more in JAMA Network Open, American Medical Association (AMA): https://bit.ly/4vGsAJG

AMC researchers involved: Ian Liang En Wee, Wei Chong Tan, Iain Bee Huat Tan, Kelvin Bryan Tan

Collaborators: Jinghao Nicholas Ngiam, David Chien Boon Lye, Calvin J Chiew (Communicable Diseases Agency, Singapore); Muhammad Ismail Bin Abdul Malek, Russell Jingxian Li (National Centre for Infectious Diseases - NCID); Yong Yi Tan, Jue Tao Lim (NTU Lee Kong Chian School of Medicine); Matilda Lee (National University Cancer Institute, Singapore - NCIS), Elise Kiat Yee Vong (Tan Tock Seng Hospital (TTSH))

Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

01/09/2026

The anion gap (AG) is commonly used to screen for acid-base disorders. The diagnostic cut-off for high anion gap metabolic acidosis (HAGMA) was determined decades ago with earlier laboratory techniques. With modern laboratory methods, it was thought that the cut-off may have changed as measured levels of serum chloride may be higher. On the other hand, modern laboratory equipment are still calibrated to familiar reference ranges established with earlier techniques.

Researchers from Changi General Hospital (CGH) and SingHealth assessed the performance of AG as a screening test for HAGMA and to determine the optimal diagnostic threshold of AG for HAGMA.

The team analysed data from 16,475 patients and concluded that an AG threshold value of ≥15 mEq/L has a high sensitivity for HAGMA.

Read more in Singapore Medical Journal (SMJ), Wolters Kluwer: https://bit.ly/4mGudTQ

AMC researchers involved: Chang Yin Chionh, Carolyn Shan-Yeu Tien, Wenxiang Yeon, Changi REnal MEdicine REsearch (CREMERE) Group

Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

27/08/2026

Congenital hyperinsulinism (CHI) is the commonest cause of persistent hypoglycaemia in neonates and infants. Diazoxide remains first-line therapy, but variability in response and adverse effects poses clinical challenges.

Researchers from KK Women's and Children's Hospital and Duke-NUS Medical School conducted a structured review on diazoxide pharmacokinetics, pharmacodynamics, and safety in neonatal and infant populations. They synthesised available evidence alongside developmental pharmacology principles to explore age-dependent variability in drug response and toxicity.

The review highlights the potential role of individualised dosing strategies based on clinical phenotype, genotype, and patient-specific risk factors, while acknowledging current evidence limitations. These findings support a more tailored approach to diazoxide use to optimise safety and effectiveness in CHI management.

Read more in Frontiers in Pharmacology, Frontiers: https://bit.ly/41IINAE

AMC researchers involved: Teresa Wong, Daniel Chan, Cherie Chua, Wenqi Cher, Selina Lim, Suresh Chandran, Fabian Yap

Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

25/08/2026

Can an AI-powered eye scan help predict diabetic foot disease? 👁️🦶

Diabetic foot disease is one of the most common and serious complications of diabetes, often leading to foot ulcers, infections, and lower-limb amputations. Yet, identifying patients at risk early remains a challenge.

Researchers from Singapore National Eye Centre / Singapore Eye Research Institute, Singapore General Hospital and Agency for Science, Technology and Research (A*STAR), led by Assoc Prof Yu-Chi Liu, have developed an AI-powered approach that combines non-invasive corneal imaging with routine blood tests to predict an individual’s risk of developing diabetic foot disease.

Their shows that tiny changes in the nerves of the eye could provide an early window into diabetic nerve damage. By combining non-invasive eye scans with routine blood test results, the AI model identified patients at risk of diabetic foot disease with up to 94% accuracy, paving the way for earlier intervention before serious complications develop.

👉 Swipe for more!

Assoc Prof Yu-Chi Liu, Dr Chang Liu, Dr Lei Zhu, Mr Gavin Patrick O’donnell, Ms Mui Hui Koh, Dr Mingyi Yu, Ms Isabelle Xin Yu Lee, Prof Ching-Yu Cheng, Dr Jun Zhou, Dr Xinxing Xu, Dr Rick Siow Mong Goh, Dr Yong Liu

24/08/2026

Are you passionate about improving our population's health and healthcare systems through ? 🤔

Applications for the Duke-NUS PhD in Population Health and Health Services are now open till 31 October 2026!

Designed for healthcare professionals who want to build their research capabilities while continuing their careers, the programme equips you with advanced research skills to tackle real-world healthcare challenges and generate evidence that can improve practice, policy and population health outcomes.

✏️ Apply now at https://for.sg/phd-in-population-health-and-health-services-application-page

📄 For more details: https://for.sg/phd-in-population-health-and-health-services

21/08/2026

in Minutes: RGR highlights

What lies beneath chronic wounds and how research can improve patient outcomes?

Building on the discussions from our July Research Grand Rounds, we transformed key insights by Ms Fazila Aloweni and Ms Nanthakumahrie Gunasegaran into bite-sized infographics.

We hope these would spark conversations through our sharing on how research is improving care for patients with chronic wounds.

Browse through to learn more.

🤖 Presentation content is reproduced with permission and reviewed for accuracy before publication. Infographic produced by ChatGPT. Please credit both the speakers and AMRI if sharing or reproducing this content.

20/08/2026

Ureteral stenting is widely adopted in kidney transplantation (KTx) to mitigate major urological complications (MUC); however, heterogeneous practices continue to shape clinical decision-making regarding its influence on infectious outcomes, optimal dwell time, preferred removal technique, and the merits of routine versus selective stenting strategies.

Researchers from Singapore General Hospital synthesised contemporary evidence to clarify best practices and identify future directions for stent use in KTx recipients.

Their key findings show that removing internal double-J stents 14–21 days after transplant using minimally invasive, office-based approaches strikes the best balance between preventing major urological complications and reducing UTI risk, and emerging tools like stent-on-string, single-use cystoscopy, and magnetic stents are reshaping patient experience and cost-effectiveness. The debate between routine and selective stenting remains ongoing, with personalised approaches on the horizon.

Read more in World Journal of Urology, Springer Nature: https://bit.ly/4mBFlkI

AMC researchers involved: Kit Mun Chow, Julene Ong Hui Wen, Daniel Goh Wen Xiang, Valerie Gan Huei Li, Edwin Jonathan Aslim, Lay Guat Ng, Tze Kiat Ng, Ee Jean Lim

Collaborators: Rachel Lau Shu-En (National University Hospital - NUH), Bhaskar Kumar Somani (University Hospital Southampton), Theodoras Tokas (University General Hospital of Heraklion), Selcuk Guven (Istanbul Medipol Universit), Vineet Gauhar (Ng Teng Fong General Hospital)

Visit Academic Medicine Research Institute - AMRI at https://www.singhealthdukenus.com.sg/research

19/08/2026

Come join us at the REMEDIS-SDCT Symposium 2026 on 1 Sep 2026 at the NCCS Lecture Theatre.

Learn more about the latest developments in cell and gene therapy, regenerative medicine and biotechnology manufacturing through a series of insightful talks and discussions.

Registration is free. Learn more and register at https://for.sg/remedsdct2026.

See you there!

17/08/2026

Research isn’t separate from nursing – it is an extension of it.

In this special Singapore Nurses’ Day edition of Not-Your-Usual-Scientist, Ms Nanthakumahrie Gunasegaran shares how an early interest in evidence-based practice evolved into a passion for nursing .

As a Nurse Clinician and certified Wound, Ostomy and Continence Nurse at Singapore General Hospital, she combines clinical care with to improve patient outcomes and advancing nursing practice.

“The best research starts at the bedside. Many meaningful studies begin with everyday clinical challenges and the desire to provide better care for our patients.” – Ms Nanthakumahrie Gunasegaran.

Read the full story: https://for.sg/interview-with-ms-nanthakumahrie

14/08/2026

in Minutes: RGR highlights

Implementing AI in healthcare isn’t just about developing better technology – it's about ensuring it is trustworthy, equitable and ready for real-world care.

Drawing on the discussion from our May Research Grand Rounds, we have brought together key insights from Clin Asst Prof Alvin Ngeow, Clin Assoc Prof Oh Choon Chiat and Prof Nick Sevdalis into an easy-to-digest infographic.

We hope this infographic offers an overview of what it takes to translate AI innovation into meaningful patient impact.

Read below to learn more.

🤖 Presentation content is reproduced with permission and reviewed for accuracy before publication. Infographic produced by ChatGPT. Please credit both the speakers and AMRI if sharing or reproducing this content.

Address

Academia, Ngee Ann Kongsi Discovery Tower Level 7, 20 College Road
Singapore
169856

Opening Hours

Monday	08:30 - 18:00
Tuesday	08:30 - 18:00
Wednesday	08:30 - 18:00
Thursday	08:30 - 18:00
Friday	08:30 - 18:00

Website

https://www.singhealthdukenus.com.sg/research

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