Siriraj Initiative in Systems Pharmacology

Siriraj Initiative in Systems Pharmacology where Systems Pharmacology meets Innovative Multi-omic technology to unveil disease's secrets

Advancement in the 21st century is revolutionizing medicine to be more precise and clinically tailored for individual patients. While we are equipped with more efficient drugs, choosing the right drug choice for a specific subgroup of patients is still an active area of research. In the past few years, more reports have shown that ethnicity contributes significantly towards the heterogeneous drug response. Understanding how the genetic backgrounds are associated with commonly observed variability in therapeutic sensitivity will help fulfill this critical research gap. Systems Pharmacology is a new discipline that is gaining attentions in the international research community. Focusing on quantitative reasoning and the investigation of drug mechanisms from the cellular level upto the population level, Systems Pharmacology helps advance drug discovery and development in a network-centric fashion. Realizing the potentials of this new research paradigm, the Faculty of Medicine Siriraj Hospital, as a leading medical research institute in Thailand, has launched a new research program called the Siriraj Initiative in Systems Pharmacology (SiSP) in 2015 to fulfill this research need. Led by two young pioneers, Dr.Somponnat Sampattavanich and Dr.Siwanon Jirawatnotai both ex-Bostonian researchers, SiSP is designed from its start to be a multidisciplinary, collaborative and resourceful incubator for talented Thai scientists. To dates, there are already over 40 active researchers from both inside and outside Siriraj that are working under the SiSP program. Current research activities range from investigation of prognostic biomarkers for cancer treatment to whole-genome screening of proteins that are responsible for Orientia tsutsugamushi infection in scrub typhus. The core instrument at SiSP is the high-content imaging platform for high-throughput phenotypic screening and proteomic measurement. This technology enables quantitative measurement of single-cell heterogeneity up to over 10,000 data points per day. Other core technologies include the development of advanced biosensor for live measurement of signaling network activity and point-of-care diagnostics. These cutting edge technology will provide the necessary foundations for the next generation of Thai pharmaceutical industry.

We are proud to work on this project. Thank you the Pharmacology department and Siriraj executive team for the success o...
23/07/2026

We are proud to work on this project. Thank you the Pharmacology department and Siriraj executive team for the success of MOU signing, and many thanks to our partner, InvitroCue. Time for real work!

ยินดีต้อนรับ Resident artists จาก Freak lab ครับ
23/07/2026

ยินดีต้อนรับ Resident artists จาก Freak lab ครับ

Day 5: Implementing screening knowledge on lead identification and class completion party
17/07/2026

Day 5: Implementing screening knowledge on lead identification and class completion party

Day 4: data analyticsParticipants work in team to analyze real dataset using Harmony platform.        2026
16/07/2026

Day 4: data analytics

Participants work in team to analyze real dataset using Harmony platform.

2026

Day 3: Cell paint and 3D imaging workshop        2026
15/07/2026

Day 3: Cell paint and 3D imaging workshop

2026

Day 2: HT compound screening, Microscopy fundamentals and assay design, hands-on workshop        2026
14/07/2026

Day 2: HT compound screening, Microscopy fundamentals and assay design, hands-on workshop

2026

We are starting the day 1 of SiSP-Revvity high-content screening summer school 2026!We have participants from major HCS ...
13/07/2026

We are starting the day 1 of SiSP-Revvity high-content screening summer school 2026!

We have participants from major HCS centers in Thailand. Yet another scientifically inspiring week @ SiSP

Many thanks to Revvity for making possible this training.
2026

Learn about what experts shared at the final panel discussion during the SiSP Spatial Biology Summer School 2026.
10/07/2026

Learn about what experts shared at the final panel discussion during the SiSP Spatial Biology Summer School 2026.

Introduction Spatial biology has rapidly emerged as one of the most transformative technologies in modern biomedical research. By preserving the spatial organization of cells while simultaneously measuring molecular features, spatial biology enables researchers to investigate biological systems in

SiSP outing - Jan 8-9 2026 @ Kaeng Krachan areaWork Hard, play harder!
09/01/2026

SiSP outing - Jan 8-9 2026 @ Kaeng Krachan area
Work Hard, play harder!

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