08/06/2026
📌An eighty-year-old male patient presented to the internal medicine clinic with unintentional weight loss of 23 kg over the previous two months, accompanied by night sweats and fever.
📌Laboratory evaluation revealed: Thrombocytopenia
Anemia
Elevated inflammatory markers
Increased urea levels
📌Abdominal ultrasonography revealed splenomegaly. Extending inferiorly from the lower pole of the spleen, there was a hypodense lesion, which had an increased FDG uptake. There was no peripheral or systemic lymph node involvement. Based on these findings, splenectomy was performed.
📌Immunohistochemical analyses showed that the atypical large cells expressed CD20, PAX5, BCL6, MUM1, and FOXP1. Pancytokeratin, c-MYC, CD5, BCL2, and CD10 expression were negative.
🌟What’s the diagnosis?
To find out check out our article:
DOI:10.4274/tmsj.galenos.2026.2025-12-2