Dr. Melih Aygün

Dr. Melih Aygün Kısırlık Tedavisi, Tüp Bebek ve Kadın Doğum Uzmanı
Infertility Specialist&Obstetrician&Gynaecologist
📱+90 542 170 30 60
📞+90 850 333 0388
📍Şişli, İstanbul

22/08/2026

Why Is IVF Not Successful the First Time?

IVF does not always result in pregnancy on the first attempt, even when treatment is carefully planned. IVF success depends on several biological factors working together, including egg quality, s***m quality, embryo development, uterine health, hormone balance and maternal age. For this reason, an unsuccessful first IVF cycle does not necessarily mean that there is a serious problem or that future IVF treatment will fail.

Why Can a Healthy Embryo Fail to Implant?

An embryo may appear healthy during laboratory evaluation but still fail to implant in the uterus. Embryo implantation is a complex biological process influenced by chromosomal health, endometrial receptivity, hormonal conditions and the timing of embryo transfer.

Human reproduction is naturally not 100% efficient. Even in healthy couples without known fertility problems, not every embryo develops into a successful pregnancy. Therefore, implantation failure after IVF does not automatically mean that the treatment was performed incorrectly.

Can IVF Be More Successful After the First Attempt?

The first IVF cycle can provide valuable information about ovarian response, egg quality, fertilization, embryo development and the uterine response to treatment. Fertility specialists can use these findings to personalize the next IVF protocol and adjust medication, embryo transfer strategy or other parts of treatment when necessary.

One unsuccessful IVF cycle does not mean IVF will never work. Careful evaluation, individualized fertility treatment and appropriate follow-up can help identify factors that may improve the chances of IVF success in future cycles.

This content is intended for informational purposes only and should not be used for diagnosis or treatment.

Infertility Specialist
Dr. Melih Aygün
☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, İstanbul
🌐 drmelihaygun.com

18/08/2026

KI - Eizellqualität

Die Eizellqualität ist ein zentraler Faktor bei einer IVF-Behandlung. Sie beeinflusst Befruchtung, Embryonalentwicklung und Schwangerschaftschancen. Besonders wichtig ist das Alter der Frau, da die biologische Kompetenz der Eizellen mit zunehmendem Alter abnehmen kann. Beim Social Freezing werden unbefruchtete Eizellen eingefroren, um ihre Eigenschaften zum Zeitpunkt der Entnahme möglichst zu bewahren. Das kann aus persönlichen oder medizinischen Gründen erfolgen, garantiert jedoch keine spätere Schwangerschaft.

Künstliche Intelligenz zur Beurteilung der Eizellqualität

Künstliche Intelligenz kann die reproduktionsmedizinische Beurteilung unterstützen. KI-Systeme analysieren Bilddaten und strukturelle Merkmale von Eizellen, etwa Morphologie und Reifungszeichen. Ziel ist es, Muster zu erkennen, die mit dem Entwicklungspotenzial zusammenhängen können. Dadurch lassen sich Qualitätsunterschiede standardisierter erfassen. Die KI ersetzt jedoch weder die ärztliche Beurteilung noch die embryologische Expertise.

KI in der Reproduktionsmedizin: Chancen und Grenzen

KI-gestützte Analyse kann zusätzliche Informationen für die IVF-Planung liefern. Entscheidend bleiben jedoch Alter, ovarielle Reserve, Befruchtungsverlauf, Embryonalentwicklung und die individuelle medizinische Situation. Deshalb sollte die Bewertung der Eizellqualität immer im Gesamtkontext einer fachärztlichen Beratung erfolgen.

Diese Inhalte dienen ausschließlich Informationszwecken und sind nicht zur Diagnose oder Behandlung bestimmt.

Facharzt für Gynäkologie und Reproduktionsmedizin
Dr. Melih Aygün
☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, Istanbul
🌐 drmelihaygun.com

Micro-TESE Procedure in TurkeyMicro-TESE, or microsurgical testicular s***m extraction, is an advanced s***m retrieval p...
06/08/2026

Micro-TESE Procedure in Turkey

Micro-TESE, or microsurgical testicular s***m extraction, is an advanced s***m retrieval procedure mainly used for men with non-obstructive azoos***mia, where no s***m is found in the ej*****te because production is severely impaired.

How Is Micro-TESE Performed?

Under anaesthesia, the surgeon makes a small scrotal incision and examines testicular tissue with an operating microscope. Selected seminiferous tubules are removed and immediately assessed by an embryologist. When viable s***m are found, they may be used fresh or frozen for ICSI.

Micro-TESE aims to find small areas of s***m production while limiting unnecessary tissue removal. However, s***m retrieval cannot be guaranteed. Results depend on the underlying diagnosis, genetic findings, previous surgery and testicular function.

Who May Be Suitable for Micro-TESE in Turkey?

Before Micro-TESE treatment in Turkey, patients should undergo a detailed male infertility evaluation, including semen analyses, hormone tests, physical examination and, when necessary, genetic testing. These findings may influence both s***m retrieval prospects and potential risks for future children.

Patients should choose an authorised centre where a reproductive urologist, embryology laboratory and IVF team work together. Recovery, possible complications, s***m freezing and the timing of the partner’s IVF cycle should be discussed before surgery.

This content is intended for informational purposes only and should not be used for diagnosis or treatment.

Infertility Specialist
Dr. Melih Aygün
☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, İstanbul
🌐 drmelihaygun.com

Is Turkey a Good Place for IVF Treatment?Turkey can be a suitable destination for IVF, especially for international pati...
06/08/2026

Is Turkey a Good Place for IVF Treatment?

Turkey can be a suitable destination for IVF, especially for international patients seeking experienced fertility specialists, modern embryology laboratories and coordinated medical care. Major cities such as Istanbul have Ministry of Health-authorised fertility centres. However, clinic quality, laboratory standards, treatment protocols and communication can vary, making careful evaluation essential.

How to Choose an IVF Clinic in Turkey

A reliable clinic should provide a personalised assessment based on age, ovarian reserve, s***m quality, infertility diagnosis and previous treatments. Patients should ask about laboratory standards, specialist experience, embryo culture, freezing systems, patient identification and quality-control procedures.

IVF success rates must also be interpreted carefully. Outcomes depend on individual medical factors, while percentages may be reported per embryo transfer, egg collection or complete cycle. Trustworthy clinics explain these differences and do not promise guaranteed pregnancy.

Is IVF in Turkey Suitable for International Patients?

Turkey may offer convenient travel, multilingual coordination and treatment options at different price levels. Patients should confirm what the package includes, how long they must stay, which tests can be completed at home and how follow-up care will be organised.

The best IVF destination depends not only on the country, but on choosing an authorised clinic with transparent information, ethical practice, strong laboratory standards and personalised treatment planning.

This content is intended for informational purposes only and should not be used for diagnosis or treatment.

Infertility Specialist
Dr. Melih Aygün
☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, İstanbul
🌐 drmelihaygun.com

Can You Choose Gender with IVF in Turkey?Elective gender selection with IVF is not permitted in Turkey for personal pref...
06/08/2026

Can You Choose Gender with IVF in Turkey?

Elective gender selection with IVF is not permitted in Turkey for personal preference or family balancing. Turkish regulations allow embryo genetic testing only when there is a valid medical indication. Therefore, IVF clinics cannot legally offer parents the option of choosing a male or female embryo based solely on preference.

When Is Embryo S*x Selection Medically Permitted?

In medically necessary cases, preimplantation genetic testing, known as PGT, may be used to examine embryos for inherited conditions. Some genetic disorders are linked to the X or Y chromosome and may mainly affect one biological s*x. When a documented risk exists, a fertility specialist and medical geneticist can assess whether PGT is appropriate.

The purpose is disease prevention, not elective gender selection. Treatment planning must be carried out in authorised assisted reproduction and genetics centres after reviewing family history, genetic test results and the clinical diagnosis.

IVF, PGT and Gender Selection Rules in Turkey

IVF treatment, genetic embryo testing and elective s*x selection are different procedures. IVF supports fertilisation and pregnancy, while PGT may identify certain chromosomal or single-gene disorders before embryo transfer. It cannot guarantee implantation, pregnancy or a healthy birth.

Couples considering IVF in Turkey should begin with a personalised fertility and genetic assessment. Treatment must follow Turkish law, medical necessity and ethical standards. Claims that routine gender selection is available in Turkey should be verified with a Ministry of Health-authorised IVF centre.

This content is intended for informational purposes only and should not be used for diagnosis or treatment.

Infertility Specialist
Dr. Melih Aygün
☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, İstanbul
🌐 drmelihaygun.com

Artificial Intelligence in Routine IVF PracticeArtificial intelligence is becoming a practical decision-support tool in ...
06/08/2026

Artificial Intelligence in Routine IVF Practice

Artificial intelligence is becoming a practical decision-support tool in modern IVF care. In the embryology laboratory, AI can analyse time-lapse images and clinical data to support embryo assessment, detect developmental patterns and improve consistency. It may also assist with ovarian stimulation planning, laboratory workflow, quality control and treatment-outcome prediction.

How AI Supports IVF Treatment

AI does not perform IVF independently and does not replace the fertility specialist or embryologist. Its role is to organise complex information and provide an additional data-based perspective. Embryo selection is one of the most studied applications, but an AI score cannot guarantee implantation, pregnancy or live birth. Age, ovarian reserve, s***m quality, embryo genetics, uterine factors, laboratory conditions and previous treatment history must still be assessed together.

Safe and Responsible Use of AI in Fertility Care

Routine use of artificial intelligence in IVF requires clinical validation, transparent performance standards, data protection and continuous professional oversight. An algorithm trained in one patient population may not perform equally well in another, so bias and external validation are essential. Patients should also be informed when AI contributes to a clinical or laboratory decision.

The most responsible approach is human-led, evidence-based IVF care supported by carefully validated technology. AI may improve consistency and efficiency, but personalised treatment planning, medical judgement and clear communication remain central. The key question is not simply whether a clinic uses AI, but how the system has been validated, where it is used and how specialists interpret its results.

This content is intended for informational purposes only and should not be used for diagnosis or treatment.

Infertility Specialist
Dr. Melih Aygün
☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, İstanbul
🌐 drmelihaygun.com

30/07/2026

Embryonen live vom Handy verfolgen

Dank moderner Time-Lapse-Technologie kann die Entwicklung von Embryonen während einer IVF-Behandlung heute lückenlos dokumentiert werden. Die aufgenommenen Bilder werden über einen geschützten Online-Zugang bereitgestellt, sodass der Entwicklungsverlauf der Embryonen auch aus der Ferne auf dem Smartphone eingesehen werden kann.

Die kontinuierliche Bildaufzeichnung ermöglicht es dem Embryologieteam, die einzelnen Entwicklungsstadien detailliert zu beurteilen und zusätzliche Informationen über das Entwicklungspotenzial der Embryonen zu gewinnen. Diese Technologie ergänzt die embryologische Bewertung und kann die Auswahl geeigneter Embryonen für den Transfer unterstützen.

Für viele Patientinnen und Paare bedeutet diese Möglichkeit zudem mehr Transparenz während der Behandlung, da sie den Entwicklungsprozess ihrer Embryonen nachvollziehen können, ohne im Labor anwesend sein zu müssen.

Welche Technologien im Rahmen einer IVF eingesetzt werden können, wird stets individuell nach der medizinischen Situation und den Empfehlungen des behandelnden Teams entschieden.

Diese Inhalte dienen ausschließlich Informationszwecken und sind nicht zur Diagnose oder Behandlung bestimmt.

Facharzt für Gynäkologie und Reproduktionsmedizin
Dr. Melih Aygün

☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, Istanbul
🌐 drmelihaygun.com

Bir kez daha zirvede, bir kez daha hepimizin göğsünü kabartan bir başarı…Cumhuriyet'in kadınlarıyla gurur duyuyor, nice ...
27/07/2026

Bir kez daha zirvede, bir kez daha hepimizin göğsünü kabartan bir başarı…

Cumhuriyet'in kadınlarıyla gurur duyuyor, nice şampiyonluklar diliyorum. 🇹🇷❤️

22/07/2026

Embryoskop & Fairtility

Die Auswahl eines Embryos für den Transfer ist ein wichtiger Schritt im Rahmen einer IVF-Behandlung. Moderne Technologien wie das Embryoskop und Fairtility unterstützen Embryologinnen und Embryologen dabei, die Entwicklung von Embryonen detaillierter zu beurteilen und zusätzliche objektive Informationen für die Entscheidungsfindung zu erhalten.

Das Embryoskop ist ein spezielles Inkubationssystem mit integrierter Time-Lapse-Technologie. Es ermöglicht eine kontinuierliche Beobachtung der Embryonalentwicklung, ohne dass die Embryonen aus ihrer kontrollierten Umgebung entnommen werden müssen. Dadurch können einzelne Entwicklungsschritte präzise dokumentiert und ausgewertet werden.

Fairtility ergänzt diesen Prozess mithilfe künstlicher Intelligenz. Die Software analysiert bestimmte Entwicklungsmerkmale der Embryonen und erstellt, je nach System, eine objektive Bewertung oder ein Scoring. Diese Analyse dient als zusätzliche Unterstützung für das IVF-Team und kann helfen, die Auswahl des Embryos für den Transfer besser zu strukturieren.

Es ist jedoch wichtig zu wissen, dass moderne Technologien allein keinen Behandlungserfolg garantieren. Faktoren wie das Alter der Patientin, die Qualität der Eizellen und Spermien, die individuelle Krankengeschichte sowie weitere medizinische Bedingungen spielen ebenfalls eine entscheidende Rolle. Die endgültige Beurteilung und Therapieplanung erfolgt immer durch erfahrene Reproduktionsmediziner und Embryologen.

Jede Schwangerschaft ist einzigartig. Für individuelle Informationen zu Fruchtbarkeitsbehandlungen und Schwangerschaftsvorsorge wenden Sie sich bitte an qualifiziertes medizinisches Fachpersonal.

Diese Inhalte dienen ausschließlich Informationszwecken und sind nicht zur Diagnose oder Behandlung bestimmt.

Facharzt für Gynäkologie und Reproduktionsmedizin
Dr. Melih Aygün

☎️ +90 542 170 30 60
📍 Hakkı Yeten Cad. Aşçıoğlu Plaza No:17/13 Kat:6, Fulya-Şişli, Istanbul
🌐 drmelihaygun.com

15/07/2026

IVF in Turkey vs. the USA: Which Option Is Right for International Patients?

Choosing where to undergo IVF is a deeply personal decision. Turkey and the United States both offer advanced fertility treatment, but they differ in areas such as treatment regulations, overall expenses, travel requirements and follow-up planning.

🇹🇷 Why is Turkey considered for IVF?

Turkey is frequently evaluated by international patients seeking fertility treatment alongside coordinated travel and accommodation services.

Potential advantages may include:

✅ Treatment packages that may be more affordable than comparable self-funded care in the USA

✅ Modern fertility centres and experienced reproductive medicine teams

✅ Multilingual patient coordination at many international clinics

✅ The possibility of combining examinations, medication monitoring and egg retrieval within a planned stay

However, assisted reproductive treatments in Turkey are performed within national regulations. Eligibility and permitted procedures must therefore be confirmed directly with a licensed clinic before travel.

🇺🇸 What are the strengths of IVF treatment in the USA?

The USA has a large network of fertility clinics and access to advanced reproductive technologies.

Potential advantages may include:

🔹 Broad availability of specialised fertility services

🔹 Easier long-term follow-up for patients already living in the USA

🔹 Access to clinic-level outcome data through the Centers for Disease Control and Prevention

🔹 Treatment planning supported by professional guidance from organisations such as the American Society for Reproductive Medicine

The CDC publishes data on services, patient characteristics and outcomes reported by US fertility clinics. However, these figures should not be interpreted as a guarantee for an individual patient.

💰 Is IVF less expensive in Turkey?

Treatment in Turkey may involve lower clinic and hospital expenses for some international patients. The complete budget should still include:

✈️ Flights and local transportation

🏨 Accommodation

💊 Medications

🧪 Additional laboratory or genetic tests

📅 The possibility of an extended stay or repeat visit

In the USA, insurance coverage and patient expenses can vary considerably according to the state, employer plan, clinic and treatment protocol. A written, itemised quotation is therefore essential in either country.

📊 Which country has better IVF success rates?

A country-level comparison alone can be misleading. IVF outcomes are influenced by factors such as:

👩 The patient’s age and ovarian reserve

🧬 Embryo characteristics

🩺 The cause and duration of infertility

🔬 The laboratory’s experience and quality standards

📋 Previous fertility treatments

Success-rate terminology can also differ between clinics. Patients should ask whether a figure refers to pregnancy per transfer, live birth per transfer or cumulative live birth per egg-retrieval cycle. US clinic data can be reviewed through the CDC, but personal probability still requires an individual medical assessment.

⚖️ Turkey or the USA: Which is better?

Turkey may be considered by patients prioritising a potentially lower overall treatment expense and coordinated international care.

The USA may be more practical for patients who value local monitoring, easier access to follow-up appointments and publicly available clinic reporting.

The most appropriate choice is determined not only by the country, but also by the clinic’s laboratory standards, the reproductive endocrinologist’s experience, transparent communication and a personalised treatment plan.

💙 IVF should begin with a complete fertility evaluation and realistic expectations. Before travelling, patients should confirm legal eligibility, treatment details, medication arrangements, embryo-storage policies and the plan for follow-up after returning home.

Address

Teşvikiye Mah. Hakkı Yeten Caddesi Aşçıoğlu Plaza No:17 Kat:6 D:13 Fulya Şişli Istanbul
Istanbul
34349

Opening Hours

Monday 09:00 - 18:30
Tuesday 09:00 - 18:30
Wednesday 09:00 - 18:30
Thursday 09:00 - 18:30
Friday 09:00 - 18:30
Saturday 09:00 - 14:00

Telephone

+905421703060

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