Neural Stem Cell Institute

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Neural Stem Cell Institute

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The Neural Stem Cell Institute (NSCI) is dedicated to developing regenerative stem cell therapies for various diseases of the central nervous system.

Our Unique Organization

The Neural Stem Cell Institute (NSCI) is dedicated to developing regenerative stem cell therapies for various diseases of the central nervous system (CNS): the brain, spinal cord and retina, regardless of the cause of injury. Led by MacArthur “Genius” Award winner Dr. Sally Temple who helped discover and define nervous system stem cells, NSCI is the first independent, non-profit stem cell research institute in the USA. With a state of the art laboratory fully equipped to generate breakthrough discoveries, NSCI employs more than 25 leading stem cell researchers who take a multi-disciplinary approach to neural stem cell research. In addition to in-house research, NSCI provides other leading neural stem cell researchers from around the world the funding, know-how, and access to international partnerships to expedite the translation of their discovery into real-world therapies for CNS repair.

10/22/2026

TODAY at , Dr. Catherine Hamann will give a presentation titled "An Assembloid Model Of Frontotemporal Dementia With MAPT Mutations". This work aims to establish a novel human multi-region assembloid platform to investigate how tau mutations disrupt interconnected brain circuitry, advancing our understanding of frontotemporal dementia and providing a foundation for future therapeutic development.

Date | October 22
Time | 1:45 PM
Place | Magnolia 17 & 18

10/21/2026

THIS WEEK at the BMES Annual Meeting find us at Booth 201.

Are you using 2D or 3D human pluripotent cultures in your research projects? Interested in utilizing like ? Stop by for information and resources related to organoid production and QC, controlled-release growth factor technology, or more of the Institute’s research efforts. Steve and Krissy would love to chat!

Date | October 21-24
Place | Exhibit Hall

10/16/2026

Paper alert! "Multiomic Profiling of 85 iPSC Lines from Familial Dementia Reveals Cellular Diversity and Regulators of Organoid Development," now officially available in Neuron!

This was a collaborative, multi-institutional effort bringing together neurodegenerative disease expertise, stem cell biology and rigorous bioinformatics and statistics, made possible by incredible support from NINDS, NIA, Alzheimer's Association and the . By conducting deep characterization of this widely used iPSC collection, this study provides unprecedented insights into the cellular heterogeneity within iPSC lines and developmental regulatory mechanisms underlying familial dementia. Detailed knowledge of starting iPSCs is critical for successful and use of .

Read the open-access full text here: https://authors.elsevier.com/sd/article/S0896-6273(26)00732-4

More about the iPSC collection | https://www.neuralsci.org/tau

Gratitude to the co-authors and research teams who contributed to this scientific achievement and community resource!

10/15/2026

We’re heading to Orlando for the BMES Annual Meeting next week! Look for our team to hear about , , controlled-release growth factors and how to achieve higher quality cultures with less time in the hood!

Oct 21-24 | Neuracell and StemCultures teams will be at Booth 201

Oct 22 - 1:15 PM | Dr. Taylor Bertucci is speaking

Oct 22 - 1:45 PM | Dr. Catherine Hamann is speaking

Oct 23 - 4:30 PM | NSCI will be represented at the Industry Mixer (ticketed event)

09/24/2026

We are hiring a Clinical Trial Data Analyst to curate and analyze clinical outcomes from our Phase 1/2a trial of RPESC-RPE stem cell implantation for dry age-related macular degeneration (AMD).

Working alongside 4 trial investigators and 10 scientists, you will lead the statistical analysis and visualization of visual acuity, OCT imaging and other data collected from partner sites at University of Michigan, Stanford and LA Retina.

Location | Albany, NY
Full description | www.neuralsci.org/contact-us/careers

To apply, email your CV and a cover letter to [email protected] with the subject line "Clinical Trial Data Analyst Position", or apply on LinkedIn here: https://www.linkedin.com/jobs/view/4469689901/

09/18/2026

We are pleased to announce that Drs. Jeffrey Stern and Brigitte Arduini have been awarded two Regenerative Medicine Innovation Project (RMIP) renewal grants through the National Eye Institute! The awards provide continued funding to complete our Phase 1/2a clinical trial assessing transplantation of adult stem cell-derived RPE for dry Age-related Macular Degeneration (AMD) patients, while also driving translation of preclinical manufacturing development.

The trial is sponsored by Luxa Biotechnology and is being conducted by clinical site P*s Rajesh Rao, Ted Leng, and David Liao. The cell product is manufactured at Cedars-Sinai Biomanufacturing Center. We are grateful to the generous study participants for leading the way forward.

ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT04627428

08/24/2026

We were excited to host Dr. Jack Humphrey from the Icahn School of Medicine at Mount Sinai () today! He gave a terrific talk titled “Integrative functional genomics in postmortem tissues from ALS/FTD disease spectrum identify new biomarkers and mechanisms for patient stratification”.

08/20/2026

We are pleased to announce that the Regenerative Research Foundation has been named a Phase 1 winner in the NIH Complement-ARIE Reduction to Practice Challenge, hosted via HeroX.

Our team’s project, titled "Multi-Brain Region Assembloid Combinatorial Models", combines brain region-specific organoids into complex, multi-region assembloids. These breakthrough patient stem cell-based models enable more human-relevant testing for therapeutic candidates while reducing reliance on animal testing in biomedical research.

Read our full press release and project overview: https://www.businesswire.com/news/home/20260819984229/en/Regenerative-Research-Foundation-Named-a-Winner-in-NIHs-Complement-ARIE-Challenge

08/11/2026

Congratulations to Dr. Liz Fisher for receiving approval for activation of a K22 Career Transition Award from the National Institute on Aging!

The funded project investigates the mechanisms of microglia-endothelial interactions using IL1 signaling, a pro-inflammatory pathway important in innate immune signaling. The research utilizes parallel experimental approaches incorporating human iPSC-derived cellular models and in vivo mouse models to map these interactions.

This award supports Dr. Fishers’ progression from postdoctoral research toward establishing an independent research program focused on neurovascular biology and neuroinflammation.

07/09/2026

TODAY at , Dr. Brigitte Arduini will speak during the Modeling Cellular Complexity for Tissue Therapies session.

In her talk, titled "Safety and Tolerability of RPE Stem Cell-derived RPE (RPESC-RPE) Implantation in Patients with Dry Age-related Macular Degeneration (AMD)", she will discuss our testing an adult for treatment of AMD.

Date | July 9
Time | 9:15 AM
Place | Room 511c

Address

150 New Scotland Avenue
Albany, NY
12208

Telephone

+15186948188

Website

http://neuralsci.org/

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