02/28/2023
I cannot tell you how many times I have been told the equation, "Coronary perfusion pressure = Aortic diastolic pressure - Left ventricular end diastolic pressure," and boy is that only part of the story. So today, I wanted to address coronary perfusion pressure and what gets perfused when and why!
The perfusion pressure through a coronary artery, or anywhere for that matter, is a function of the pressure gradient between where flow starts and where the flow is going. In the case of the coronary arteries: we can measure the starting pressures since blood flow through the coronaries originates in the aorta, and a simple blood pressure measurement estimates our aortic pressure during systole and diastole, 120/80 mmHg in a normal patient.
We can estimate the pressure in the coronary arteries by assuming that the pressure within them is equal to the pressure in the ventricle that they are feeding as they run along the chamber. Therefore, we have a general idea of pressure in the coronaries, and as a result, the coronary perfusion pressure throughout the cardiac cycle!
🫀Left Coronary Artery: In systole, aortic pressure = 120 mmHg, while the LV systolic pressure is also 120 mmHg making the delta 0, resulting in NO coronary perfusion!
🫀Left Coronary Artery: In diastole, aortic pressure = 80 mmHg, while the LV diastolic pressure is somewhere closer to 8 to 10 mmHg, leading to a delta of roughly 70 to 72 mmHg!
🫀Right Coronary Artery: In systole, aortic pressure = 120 mmHg, while the RV systolic pressure is roughly 25 mmHg, making the delta 95 mmHg and contributing to RCA perfusion during systole (unlike the LCA)
🫀Right Coronary Artery: In diastole, aortic pressure = 80 mmHg, while the RV diastolic pressure is somewhere closer to 5 mmHg, leading to a delta of roughly 75 mmHg!
(Continued in comments)