09/22/2025
September Post
For September, I have been asked to write about Menopause and Hormone Replacement Treatment.
It is an odd area of medicine that has seen rapid abandonment by most doctors. More and more life
coaches, pharmacists, and physician extenders have taken to treating patients. The lab ordering has gotten easier, and more seductive. It is not as easy as it appears at the seminars.
People promising all kinds of great results. The packages that are sold to patients tend to be very expensive and complex. When this all breaks down, their primary care doctors end up trying to find a cost effective alternative.
I have inherited a lot of pellet disasters, salivary hormone lab failures, and breast cancer patients due to undelivered promises.
Patients need someone who will care for them regardless of results. Counsel them on good preventive care and follow up. Most important of all, the patient needs support when “one size, doesn’t fit all”, even when you pay an arm and a leg for the care.
First things first. Bio-identical hormones do not prevent cancers. My wife, Cheryl, can attest to that, and all the other promises made by weekend practitioner trainings. 2017 was a year that began with an overdue mammogram/MMG, and fortunately led to complete remission for the last eight years. All HRT carries risk. The benefits are many, when done well.
Have a safety net for HRT/Hormone Replacement Therapy. Ladies still need a once a year check in with their doctor. They need Pap and Pelvics.
They need MMGs. They need DXA scans for bone health. Someone needs to educate them as to if they have dense breasts (MRI of breasts).
They need lifestyle counseling about alcohol, to***co, high fat diets, over processed foods, hormone disrupting chemicals, high sugar intake, and monitoring insulin sensitivity and estrogen metabolism. All of these factors impact cancer development.
Women often begin to have problems with their hormones in their early to mid forties. Periods missed, heavy bleeding, insomnia. Libido tanks, and the perimenopause monster is on the loose.
Doctors can start to treat this early. Many options exist. Not all have to involve hormone levels. When things aren’t working, then it is time to consider hormone testing. My approach has been molded by many of my patients as well as learned doctors I with whom I have worked. Estrogen/E2, the primary female hormone helps with women’s curves and is the happy hormone. Progesterone/Pg, the second hormone helps with pregnancies and calming the body down. It is what helps with sleep and reducing anxiety. Testosterone/T, is lower in women, but drives libido and decision confidence.
My goal of treatment is for patients to feel better, and have their symptoms improve as much as possible. Generally, Estrogen levels around 100-200 make hot flashes, dryness, painful inter-course, and bad skin, better. Fatigue and body aches also improve with this. Progesterone levels 10-30 tend to restore good sleep, and calm anxiety.
Testosterone levels between 40-50 usually restore libido, and confidence with making decisions. I realize that sounds misogynistic. Women have reported it to me. Thus, I use it as a monitor.
Not addressed with HRT, is the mystery that is middle aged spread. Too many doctors lay that on the hormones. With the advent of GLP-1 and GIP agents, that doesn’t have to happen. GLP levels and Growth hormone decline, and this can be fought with dedication to diet, exercise, and when needed, meds. Some clinics also run Cortisol levels. These are hard to interpret. Patients really need a “cortisol rhythm”done to see if all stresses of life are driving cortisol. “Wired and tired” syndrome needs specialized therapy to get people back to “rest and digest” mode. There are no quick easy fixes here. Primary care doctors and therapists can help on the road to improvement.
There are those who live for their Progesterone to Estrogen ratios. Simply put, a ratio less than 60:1 is estrogen dominance. More weight gain, periods, cancer risk, and bloating. A ratio of over 3-500:1 is progesterone dominance. More
hot flashes, dryness, and body aches. The ratios are helpful, but some women will be mildly progesterone dominant and feel like a million bucks. The ratios are helpful, but the provider still needs to discuss treatment and think.
Hormone failures often come down to hormone disruption from food, additives, and metabolism.
Here is where the relationship becomes paramount, as patient and provider/doctor, work to solve this difficult puzzle.
For those who want to do their own calculations:
Pg is reported as pcg/ml or no/ml. 1 nannogram equals 1000 pcg.
Ex. Progesterone 20 ng/ml
Estrogen. 100 pcg/ml
That becomes. 20,000 divided by 100 equals 200.
Normal Pg/E2 ratio. No treatment change based on labs.
Lastly, there are people who cannot take HRT.
Breast, Ovarian, and Uterine cancer survivors should never use HRT. Some
oncologists allow it, very long after treatment.
That is another discussion, for another day.
Severe liver disease, uncontrolled blood pressure, and blood clotting problems are usually other reasons to avoid HRT.
Hope this has been helpful.
Thanks,
Dr. H